{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:06:45Z","timestamp":1789578405074,"version":"build-2803163510"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The link between viral infections and biliary atresia (BA), including their frequency and age of onset, remains unclear. Despite India\u2019s large population, research on this association is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In this study, 78 infants with BA and 35 age-matched controls were tested for Cytomegalovirus (CMV), Epstein\u2013Barr virus (EBV), Rotavirus (RoV), and Reovirus (ReV) using enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Active viral infections were detected in 64.1% of BA patients, evidenced by viral DNA, antigens, or elevated immunoglobulin M antibodies. CMV was the most common, present in 40% of cases, while EBV was present in 19%. RoV and ReV antigens were identified in 25.6% and 29.5% of patients, respectively. Moreover, 98.7% of BA cases had IgG antibodies to one or more viruses, versus 54.3% in controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). Multiple active infections were seen in 28% of patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A high rate of viral exposure in BA highlights the need for further research in this area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jiaps.jiaps_176_25","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:00:09Z","timestamp":1763114409000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Seroprevalence of Common Viruses in Early Infancy in North Indian Children with Biliary Atresia"],"prefix":"10.4103","volume":"31","author":[{"given":"Anil Kumar","family":"Ram","sequence":"first","affiliation":[{"name":"Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Prakash","family":"Kanojia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prema","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashwant","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/hep.510230652","article-title":"Biliary atresia: Current concepts and research directions. 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