{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:21:18Z","timestamp":1787844078148,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Vulvar lichen sclerosus et atrophicus is an inflammatory disease which can affect the pediatric age group, although rarely. Its prevalence is underestimated. It may have genital or extragenital manifestations. If left untreated, it may progress to complications which hamper the quality of life. The treatment of choice is topical clobetasol propionate. Here, we present a case of prepubertal vulvar LS, which was refractory to topical clobetasol but responded to topical tacrolimus application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jiaps.jiaps_188_21","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T02:52:24Z","timestamp":1693882344000},"page":"345-347","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Vulvar Lichen Sclerosus Et Atrophicus"],"prefix":"10.4103","volume":"28","author":[{"given":"Thasneem S","family":"Luqman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Kalavant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Sunil Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AR","family":"Swathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20240905","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(98)08228-2","article-title":"Lichen sclerosus","volume":"353","author":"Powell","year":"1999","journal-title":"Lancet"},{"key":"R2-16-20240905","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1067\/mjd.2001.113474","article-title":"Childhood vulvar lichen sclerosus: An increasingly common problem","volume":"44","author":"Powell","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"R3-16-20240905","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jaad.2006.02.029","article-title":"Infantile perineal protrusion","volume":"54","author":"Khachemoune","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"R4-16-20240905","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1016\/j.jaad.2010.06.011","article-title":"A double-blind, randomized controlled trial of clobetasol versus pimecrolimus in patients with vulvar lichen sclerosus","volume":"64","author":"Goldstein","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"R5-16-20240905","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/jdv.13136","article-title":"Evidence-based (S3) guideline on (anogenital) lichen sclerosus","volume":"29","author":"Kirtschig","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R8-16-20240905","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejogrb.2012.01.016","article-title":"The surgical management of complications of vulval lichen sclerosus","volume":"162","author":"Gurumurthy","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R9-16-20240905","doi-asserted-by":"crossref","first-page":"210e","DOI":"10.1097\/PRS.0b013e3181ea9386","article-title":"New surgical approach to lichen sclerosus of the vulva: The role of adipose-derived mesenchymal cells and platelet-rich plasma in tissue regeneration","volume":"126","author":"Casabona","year":"2010","journal-title":"Plast Reconstr Surg"}],"container-title":["Journal of Indian Association of Pediatric Surgeons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jiaps.jiaps_188_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:04:31Z","timestamp":1787843071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jiaps.jiaps_188_21"}},"subtitle":["Refractory to Standard Therapy"],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jiaps.jiaps_188_21","relation":{},"ISSN":["0971-9261"],"issn-type":[{"value":"0971-9261","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}