{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:22:50Z","timestamp":1787772170934,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim is to study the various histopathological changes in the liver in pediatric patients with choledochal cyst (CC) and correlate with the presentation and type of cyst.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a prospective observational study including all pediatric patients who underwent CC excision, histopathological changes of the liver in the form of cholestasis (CHS), portal inflammation (PI), bile duct proliferation (BDP), and fibrosis were studied and graded using a scoring system. They were analyzed in relation to age, sex, symptoms, and type of the cyst.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All 30 patients of CC showed various degrees of histopathological changes in the liver in the form of CHS, PI, BDP, and liver fibrosis. Patients &lt;1 years had 9\/13 (69.2%) cystic variety and those &gt;1 years had 17\/17 (100%) fusiform variety of CC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Patients &lt;1 years frequently presented with jaundice and hepatomegaly and those &gt;1 years presented with pain abdomen (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.002). Higher grades of liver fibrosis and BDP were seen in the cystic variety compared to the fusiform variety (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). However, no significant association was found with CHS and PI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 1.23).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Histopathological changes in the liver of varying grades are seen in all patients of CC. Patients of CC &lt;1 year presented frequently with jaundice, had the cystic type, and had a higher degree of liver damage on histopathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jiaps.jiaps_195_23","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T15:00:38Z","timestamp":1715180438000},"page":"213-218","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Liver Histopathology in Pediatric Patients with Choledochal Cyst"],"prefix":"10.4103","volume":"29","author":[{"given":"Kumar","family":"Mayank","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Lady Hardinge Medical College and Kalawati Saran Children\u2019s Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasis Roy","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Lady Hardinge Medical College and Kalawati Saran Children\u2019s Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lady Hardinge Medical College and Kalawati Saran Children\u2019s Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh Kumar","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Lady Hardinge Medical College and Kalawati Saran Children\u2019s Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"R1-20240905","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/BF02349784","article-title":"Bile duct cysts:A changing spectrum of disease","volume":"3","author":"Gigot","year":"1996","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"R2-20240905","first-page":"1","article-title":"Congenital choledochal cyst, with a report of 2, and an analysis of 94, cases","volume":"108","author":"Alonso-Lej","year":"1959","journal-title":"Int Abstr Surg"},{"key":"R3-20240905","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0002-9610(77)90359-2","article-title":"Congenital bile duct cysts:Classification, operative procedures, and review of thirty-seven cases including cancer arising from choledochal cyst","volume":"134","author":"Todani","year":"1977","journal-title":"Am J Surg"},{"key":"R4-20240905","first-page":"231","article-title":"Congenital choledochal cysts:New etiological concept based on anomalous relationships of the common bile duct and pancreatic bulb","volume":"12","author":"Babbitt","year":"1969","journal-title":"Ann Radiol (Paris)"},{"key":"R5-20240905","first-page":"73","article-title":"Choledochal cyst:12 years'experience with 69 cases","volume":"2","author":"Kaminsky","year":"1994","journal-title":"Surg Child Int"},{"key":"R6-20240905","first-page":"868","article-title":"Choledochal cyst \u2013A different disease in newborns and infants","volume":"24","author":"Nazir","year":"2014","journal-title":"J Coll Physicians Surg Pak"},{"key":"R7-20240905","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0022-3468(95)90059-4","article-title":"Biliary amylase and congenital choledochal dilatation","volume":"30","author":"Davenport","year":"1995","journal-title":"J Pediatr Surg"},{"key":"R8-20240905","first-page":"205","article-title":"Pathological reappraisal of biliary atresia and new aspects on its aetiology","volume":"7","author":"Okamoto","year":"1975","journal-title":"J Jpn Soc Peaditr Surg"},{"key":"R9-20240905","first-page":"52","article-title":"Significance of various histopathological features in neonatal cholestasis","volume":"10","author":"Shenbagam","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"R10-20240905","first-page":"113","article-title":"Cirrhotic changes in choledochal cyst in relevance to increasing age at presentation","volume":"20","author":"Talat","year":"2016","journal-title":"JRMC"},{"key":"R11-20240905","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00383-013-3368-7","article-title":"Clinical analysis of liver fibrosis in choledochal cyst","volume":"29","author":"Fumino","year":"2013","journal-title":"Pediatr Surg Int"},{"key":"R12-20240905","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1053\/jpsu.2002.36186","article-title":"Choledochal cysts:Age of presentation, symptoms, and late complications related to Todani's classification","volume":"37","author":"de Vries","year":"2002","journal-title":"J Pediatr Surg"},{"key":"R13-20240905","first-page":"186","article-title":"Choledochal cysts \u2013Differences in children and adults","volume":"83","author":"Chaudhary","year":"1996","journal-title":"Br J Surg"},{"key":"R14-20240905","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00383-013-3453-y","article-title":"Liver histology in choledochal cyst- pathological changes and response to surgery:The overlooked aspect?","volume":"30","author":"Sugandhi","year":"2014","journal-title":"Pediatr Surg Int"},{"key":"R15-20240905","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.18410\/jebmh\/2020\/623","article-title":"A study of histopathological profile of liver in paediatric choledochal cyst","volume":"7","author":"Padmaja","year":"2020","journal-title":"J Evid Based Med Health"},{"key":"R16-20240905","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-0676.1983.tb00865.x","article-title":"Histopathology of the intrahepatic biliary tree","volume":"3","author":"Baptista","year":"1983","journal-title":"Liver"},{"key":"R17-20240905","first-page":"198","article-title":"The different clinical and liver pathological characteristics between the newborns and infants with choledochal cysts","volume":"32","author":"Hua","year":"2009","journal-title":"Chang Gung Med J"},{"key":"R18-20240905","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/S0022-3468(99)90308-1","article-title":"Influence of age on the presentation and outcome of choledochal cyst","volume":"34","author":"Suita","year":"1999","journal-title":"J Pediatr Surg"},{"key":"R19-20240905","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.jpedsurg.2011.09.017","article-title":"Clinical characteristics of liver fibrosis in patients with choledochal cysts","volume":"46","author":"Fujishiro","year":"2011","journal-title":"J Pediatr Surg"},{"key":"R20-20240905","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00383-006-1771-z","article-title":"Experience with choledochal cysts in infants","volume":"22","author":"Vijayaraghavan","year":"2006","journal-title":"Pediatr Surg Int"},{"key":"R21-20240905","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1259\/0007-1285-53-633-906","article-title":"Prenatal ultrasound demonstration of a choledochal cyst","volume":"53","author":"Dewbury","year":"1980","journal-title":"Br J Radiol"},{"key":"R22-20240905","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-0676.1986.tb01067.x","article-title":"Immunohistochemical study on bile ductular proliferation in various hepatobiliary diseases","volume":"6","author":"Nakanuma","year":"1986","journal-title":"Liver"},{"key":"R23-20240905","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-2008-1066189","article-title":"Characteristics of choledochal cysts in neonates and early infants","volume":"5","author":"Todani","year":"1995","journal-title":"Eur J Pediatr Surg"},{"key":"R24-20240905","doi-asserted-by":"crossref","first-page":"816","DOI":"10.7196\/SAMJ.8633","article-title":"Controversies in choledochal malformation","volume":"104","author":"Atkinson","year":"2014","journal-title":"S Afr Med J"},{"key":"R25-20240905","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.jpedsurg.2010.01.030","article-title":"Histopathologic improvement in biliary cirrhosis after definitive surgery for choledochal cyst","volume":"45","author":"Ishimaru","year":"2010","journal-title":"J Pediatr Surg"},{"key":"R26-20240905","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1055\/s-2007-964950","article-title":"Hepatic fibrosis with choledochal cyst in infants and children \u2013An immunohistochemical assessment","volume":"17","author":"Gong","year":"2007","journal-title":"Eur J Pediatr Surg"},{"key":"R27-20240905","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3348\/kjr.2020.0885","article-title":"Two-dimensional shear wave elastography predicts liver fibrosis in jaundiced infants with suspected biliary atresia:A prospective study","volume":"22","author":"Chen","year":"2021","journal-title":"Korean J Radiol"}],"container-title":["Journal of Indian Association of Pediatric Surgeons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jiaps.jiaps_195_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:31:45Z","timestamp":1787769105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jiaps.jiaps_195_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jiaps.jiaps_195_23","relation":{},"ISSN":["0971-9261","1998-3891"],"issn-type":[{"value":"0971-9261","type":"print"},{"value":"1998-3891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-09-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}