{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:32:14Z","timestamp":1786739534955,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Primary gastrointestinal lymphomas (PGIL) are uncommon in children and account for &lt;5% of all pediatric malignancies. The objective of our study was to analyze the prognostic factors of pediatric PGILs with reference to its histological subtypes, stage, and outcomes using immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Twenty cases were studied over 11 years. Clinicopathological profiles, histological details, and immunohistochemical (IHC) profiles were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean age at the presentation was 6 years. Using IHC stains (CD CD10, CD19, CD20, CD3, terminal deoxynucleotidyl transferase, BCL 2 and 6, PAX 5, and MUM1), diffuse large B-cell lymphoma (DLBCL) was most prevalent (45%), followed by Burkitt lymphoma (35%) and lymphoblastic lymphoma (20%). DLBCLs (9) were classified using the Han's algorithm. Six were activated B-cell and 3 were germinal center B-cell subtypes. The cases of lymphoblastic lymphoma and those in Stage I disease had the best prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Pediatric PGILs have variable presentation, outcomes, and diverse treatment modalities depending on the histological subtypes. A panel of IHC stains can be a useful adjunct for the categorization and prognosis of pediatric PGILs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jiaps.jiaps_201_20","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T04:48:08Z","timestamp":1631767688000},"page":"327-333","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Clinicopathological Study of Primary Pediatric Gastrointestinal Lymphomas"],"prefix":"10.4103","volume":"26","author":[{"given":"Moupali","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moumita","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibsankar","family":"Barman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttara","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhumita","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchirendu","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koushik","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashoke Kumar","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20240905","first-page":"9742102","article-title":"Corrigendum to \u201cRadiological features of gastrointestinal lymphoma\u201d","volume":"2016","author":"Lo Re","year":"2016","journal-title":"Gastroenterol Res Pract"},{"key":"R2-9-20240905","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1148\/radiographics.12.5.1529131","article-title":"Non-Hodgkin lymphoma of the gastrointestinal tract","volume":"12","author":"Smith","year":"1992","journal-title":"Radiographics"},{"key":"R3-9-20240905","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1148\/rg.347140148","article-title":"From the radiologic pathology archives: Gastrointestinal lymphoma: Radiologic and pathologic findings","volume":"34","author":"Lewis","year":"2014","journal-title":"Radiographics"},{"key":"R4-9-20240905","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/1097-0142(197808)42:2<693::AID-CNCR2820420241>3.0.CO;2-J","article-title":"Lymphomas of the gastrointestinal tract: A study of 117 cases presenting with gastrointestinal disease","volume":"42","author":"Lewin","year":"1978","journal-title":"Cancer"},{"key":"R5-9-20240905","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s11605-015-3052-4","article-title":"Primary gastrointestinal Non-Hodgkin's lymphoma of the small and large intestines: A systematic review","volume":"20","author":"Lightner","year":"2016","journal-title":"J Gastrointest Surg"},{"key":"R7-9-20240905","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/0971-5851.89786","article-title":"Primary pediatric gastrointestinal lymphoma","volume":"32","author":"Bandyopadhyay","year":"2011","journal-title":"Indian J Med Paediatr Oncol"},{"key":"R8-9-20240905","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4103\/0019-509X.197718","article-title":"Primary gastrointestinal lymphomas in children: An experience of 12 years from a tertiary care center of North India","volume":"53","author":"Qadri","year":"2016","journal-title":"Indian J Cancer"},{"key":"R9-9-20240905","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/bjs.18004921319","article-title":"Primary malignant lymphoid tumours of the intestinal tract. 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