{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:34Z","timestamp":1787169814994,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"\n Introduction:<\/jats:title>\n Intestinal fatty acid-binding protein (I-FABP) is located in the apex of mature enterocytes and released into circulation; once the injury of enterocyte happens, its circulating levels are considered an early and sensitive marker of intestinal ischemia as in necrotizing enterocolitis (NEC); because of its small molecular weight, it can be detected in urine.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n The aim was to study the usefulness of both serum and urine I-FABP in early diagnosis of NEC and to correlate the serum and urinary levels.<\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n This study was case\u2013control design.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Simultaneous serum and urine samples obtained at the onset of symptoms, in 40 preterms with suspected NEC, with gestational age \u00b1 27.70 weeks and birth weight \u00b1 1.11 kg, i.e., 20 preterms diagnosed at Stage I, 12 preterms at Stage II, and 8 preterms at Stage III, were compared with age- and weight-matched preterms with no NEC.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n The collected data were tabulated, coded, and then analyzed using the computer program Statistical Package for the Social Science (SPSS version 22).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Serum levels of I-FABP in NEC cases were significantly higher than the control group, with a mean of 6005.77 \u00b1 6384.77 and 1480.79 \u00b1 1276.48 pg\/ml, respectively (\n P<\/jats:italic>\n < 0.001). Urine levels of I-FABP in NEC cases were significantly higher than the control group, with a mean of 5009.22 \u00b1 3941.64 and 2677.62 \u00b1 2257.29 pg\/ml, respectively (\n P<\/jats:italic>\n = 0.04). Both serum and urine I-FABP levels not only in Stage II are significantly higher than Stage I but also in Stage III are significantly higher than Stage I and II (\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n = 0.03, respectively), which showed significant positive correlation with stages of NEC (\n r<\/jats:italic>\n = 0.618;\n P<\/jats:italic>\n < 0.001;\n r<\/jats:italic>\n = 0.306;\n P<\/jats:italic>\n = 0.049, respectively). Both serum and urine I-FABP levels had a highly significant positive correlation with each other (\n r<\/jats:italic>\n = 0.406\n P<\/jats:italic>\n < 0.0001). Receiving operating characteristic curve showed an area under the curve of 0.92 and 0.81 for serum and urine I-FABP, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Whether serum or urinary I-FABP is valuable in the diagnosis and prediction of NEC and strongly correlated with the disease severity and with each other.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jiaps.jiaps_218_20","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T03:59:23Z","timestamp":1636689563000},"page":"393-400","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Potential Role of Serum Intestinal Fatty Acid-Binding Protein as a Marker for Early Prediction and Diagnosis of Necrotizing Enterocolitis in Preterm Neonates"],"prefix":"10.4103","volume":"26","author":[{"given":"Amin I. 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