{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:24:17Z","timestamp":1783347857338,"version":"3.54.6"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Intestinal ischemia\u2013reperfusion (I\/R) injury is a critical clinical condition associated with high morbidity and mortality, with acute mesenteric ischemia carrying mortality rates of 60%\u201380%. Carvedilol, a third-generation \u03b2-blocker with known antioxidant properties, has demonstrated protective effects against I\/R injury in various organs. This study aimed to investigate the effects of carvedilol on intestinal I\/R injury in an experimental rat model, with assessment of oxidative stress parameters and histopathological damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Thirty-two male Wistar albino rats were randomly divided into four groups (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8 each): sham, sham + carvedilol (2 mg\/kg IP), I\/R (30 min of superior mesenteric artery occlusion followed by reperfusion), and I\/R + carvedilol (I\/R plus 2 mg\/kg carvedilol IP immediately after reperfusion). At 48 h postprocedure, blood samples were collected for biochemical analysis, including total antioxidant status (TAS), total oxidant status (TOS), and thiol\/disulfide homeostasis parameters (sulfhydryl [SH], total thiol [TT], and disulfide bonds). Intestinal tissue samples were evaluated histopathologically using the Chiu scoring system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Carvedilol significantly reduced intestinal mucosal damage, with the I\/R + carvedilol group showing markedly lower Chiu scores compared to the untreated I\/R group (median 2.0 vs. 4.0,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Biochemically, the I\/R group exhibited significantly lower SH and TT levels than sham controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006, respectively), indicating oxidative stress. Carvedilol treatment preserved thiol status, with the I\/R + carvedilol group demonstrating significantly higher SH levels than the untreated I\/R group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002). No significant differences were observed in TAS, TOS, or glutathione levels between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Postreperfusion administration of carvedilol significantly attenuated intestinal I\/R injury, as evidenced by reduced histopathological damage scores and preserved thiol\/disulfide homeostasis. These findings suggest that carvedilol\u2019s antioxidant properties may offer therapeutic potential in intestinal I\/R injury. To our knowledge, this is the first study evaluating carvedilol in this context, warranting further investigation with different dosing regimens and timepoints.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jiaps.jiaps_24_26","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:38:14Z","timestamp":1783013894000},"page":"630-637","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Effects of Carvedilol on Intestinal Mucosa in Intestinal Ischemia Reperfusion Injury Model; An Experimental Study"],"prefix":"10.4103","volume":"31","author":[{"given":"Fatma Tugba G\u00fc\u00e7l\u00fc","family":"G\u00fcven\u00e7","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Dr. Sami Ulus Maternity and Children\u2019s Health and Diseases Training and Research Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Balci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Dr. Sami Ulus Maternity and Children\u2019s Health and Diseases Training and Research Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Nakkas","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habibe Meltem","family":"Ozguner","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismet Faruk","family":"\u00d6zg\u00fcner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Dr. Sami Ulus Maternity and Children\u2019s Health and Diseases Training and Research Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"R1-20260706","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/micr.20060","article-title":"Ischemia\/reperfusion injury: A review in relation to free tissue transfers","volume":"24","author":"Siemionow","year":"2004","journal-title":"Microsurgery"},{"key":"R2-20260706","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1590\/S0102-86502005000400013","article-title":"Pathophysiology of mesenteric ischemia\/reperfusion: A review","volume":"20","author":"Cerqueira","year":"2005","journal-title":"Acta Cir Bras"},{"key":"R3-20260706","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0039-6109(16)45628-8","article-title":"Reperfusion injury","volume":"72","author":"Zimmerman","year":"1992","journal-title":"Surg Clin North Am"},{"key":"R4-20260706","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s001099900029","article-title":"Therapeutic approaches for ischemia\/reperfusion injury in the liver","volume":"77","author":"Fan","year":"1999","journal-title":"J Mol Med (Berl)"},{"key":"R5-20260706","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00595-008-3785-8","article-title":"Oxymatrine attenuates intestinal ischemia\/reperfusion injury in rats","volume":"38","author":"Zhao","year":"2008","journal-title":"Surg Today"},{"key":"R6-20260706","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S1010-7940(00)00492-9","article-title":"Endothelial adhesivity, pulmonary hemodynamics and nitric oxide synthesis in ischemia-reperfusion","volume":"18","author":"Vural","year":"2000","journal-title":"Eur J Cardiothorac Surg"},{"key":"R7-20260706","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. 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