{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:43Z","timestamp":1787772463364,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Colorectal carcinoma (CRC) accounts for &lt;1% of all the neoplasms of children. Unfavorable histology and delayed diagnosis often result in poor outcome. This study aimed to investigate the clinical characteristic and prognosis of pediatric patients with CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective review of medical records of all patients diagnosed of CRC between 2015 and 2020 was performed. Data regarding gender, age, location, and histopathology were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seven children (5 males and 2 females) were included in the study. Age ranged between 8.6 and 11.8 years. Abdominal pain was the most common symptom. The duration between onset of symptoms to the diagnosis ranged from 5 days to 8 months. Right-sided tumors were more common than the left side. Histopathological examination showed mucinous adenocarcinoma in four\/seven patients and signet cell variant was seen in 2\/7. Immunohistochemistry was positive for cytokeratin and beta-catenin, however, all microsatellite instability markers were found negative. Despite surgical treatment and chemotherapy, four of our cases faced mortality and one patient was lost to follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CRC can present in first decade of life and often misdiagnosed. Pediatric CRC has distinct tumor biology and shares a poor prognosis. Paucity of literature from the Indian subcontinent should urge further clinicopathological trials for establishing etiology and for refining treatment recommendations in these children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jiaps.jiaps_33_21","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T10:15:56Z","timestamp":1716545756000},"page":"304-308","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Pediatric Colorectal Carcinoma"],"prefix":"10.4103","volume":"27","author":[{"given":"Nidhi","family":"Mahajan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshita","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhabi Ranu","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Sengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Khatri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niyaz","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240905","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"R2-6-20240905","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1097\/MPH.0b013e3182467f3e","article-title":"Sporadic adenocarcinoma of the colon in children: Case series and review of the literature","volume":"34","author":"Blumer","year":"2012","journal-title":"J Pediatr Hematol Oncol"},{"key":"R4-6-20240905","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"R5-6-20240905","first-page":"1353","article-title":"Colorectal carcinoma in pediatric children","volume":"37","author":"Bhatia","year":"2000","journal-title":"Indian Pediatr"},{"key":"R6-6-20240905","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4103\/0189-6725.48584","article-title":"Childhood colorectal carcinoma: A case series","volume":"6","author":"Sharma","year":"2009","journal-title":"Afr J Paediatr Surg"},{"key":"R7-6-20240905","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1200\/JCO.2007.12.6102","article-title":"Colorectal carcinoma in childhood and adolescence: A clinicopathologic review","volume":"25","author":"Hill","year":"2007","journal-title":"J Clin Oncol"},{"key":"R8-6-20240905","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12519-018-0187-x","article-title":"Comparison of the demographic characteristics of pediatric and adult colorectal cancer patients: A national inpatient sample based analysis","volume":"15","author":"Attard","year":"2019","journal-title":"World J Pediatr"},{"key":"R9-6-20240905","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00383-014-3537-3","article-title":"Colorectal carcinoma in first decade of life: Our experience","volume":"30","author":"Rahman","year":"2014","journal-title":"Pediatr Surg Int"},{"key":"R10-6-20240905","first-page":"51","article-title":"Non-familial paediatric colorectal cancers \u2013 An 18 years\u2019 experience","volume":"30","author":"Nair","year":"2009","journal-title":"Trop Gastroenterol"},{"key":"R11-6-20240905","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jpedsurg.2015.11.005","article-title":"Colorectal carcinoma in paediatric patients; a comparison with adult tumors, treatment and outcomes from National Cancer Database","volume":"51","author":"Poles","year":"2016","journal-title":"J Pediatr Surg"},{"key":"R12-6-20240905","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/0019-509X.44068","article-title":"Pediatric carcinoma of rectum \u2013 Varanasi experience","volume":"45","author":"Pandey","year":"2008","journal-title":"Indian J Cancer"},{"key":"R13-6-20240905","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5223\/pghn.2018.21.1.72","article-title":"An unusual presentation of rectal carcinoma in a child","volume":"21","author":"Tiwari","year":"2018","journal-title":"Pediatr Gastroenterol Hepatol Nutr"},{"key":"R14-6-20240905","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/MCG.0000000000000660","article-title":"World gastroenterology organisation global guidelines inflammatory bowel disease: Update August 2015","volume":"50","author":"Bernstein","year":"2016","journal-title":"J Clin Gastroenterol"},{"key":"R15-6-20240905","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.jpedsurg.2016.07.015","article-title":"Colorectal cancer in the very young: A comparative study of tumor markers, pathology and survival in early onset and adult onset patients","volume":"51","author":"Khan","year":"2016","journal-title":"J Pediatr Surg"},{"key":"R16-6-20240905","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5009\/gnl.2010.4.2.151","article-title":"Hereditary colon cancer: Lynch syndrome","volume":"4","author":"Jang","year":"2010","journal-title":"Gut Liver"},{"key":"R17-6-20240905","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/cncr.24777","article-title":"Distinct features of colorectal cancer in children and adolescents: A population-based study of 159 cases","volume":"116","author":"Sultan","year":"2010","journal-title":"Cancer"},{"key":"R18-6-20240905","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1097\/MPH.0b013e31824e38c1","article-title":"Management of colorectal carcinoma in children and young adults","volume":"34","author":"Goldberg","year":"2012","journal-title":"J Pediatr Hematol Oncol"}],"container-title":["Journal of Indian Association of Pediatric Surgeons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jiaps.JIAPS_33_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:48:05Z","timestamp":1787770085000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jiaps.JIAPS_33_21"}},"subtitle":["A Series of Seven Cases"],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jiaps.jiaps_33_21","relation":{},"ISSN":["0971-9261"],"issn-type":[{"value":"0971-9261","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}