{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:41:21Z","timestamp":1782934881759,"version":"3.54.5"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n Aim:<\/jats:title>\n Menopause associated estrogen deficiency affects bone metabolism and may increase peri implant bone resorption. Genetic polymorphisms in inflammatory and bone related genes may further influence implant outcomes. This study evaluated the association between gene polymorphisms and peri implant early crestal bone loss (ECBL) in premenopausal and postmenopausal females.<\/jats:p>\n <\/jats:sec>\n \n Setting and Design:<\/jats:title>\n This was a prospective observational clinical study conducted at a tertiary care government institution.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n The study included 146 female patients (73 premenopausal and 73 postmenopausal), each receiving a single mandibular posterior dental implant. Menopausal status was confirmed using medical history and serum estradiol quantification. A standardized two stage protocol was followed for implant placement. Cone beam computed tomography based measurements of ECBL were performed at baseline and 6 months. Genotyping of interleukin 1 alpha (IL1A 889), interleukin 1 beta (IL1B 3954) and IL1B 511, IL6 572, collagen type I alpha 1 (COL1A1), and bone gamma carboxyglutamate protein (BGP) (osteocalcin) polymorphisms was performed using real time PCR.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis Used:<\/jats:title>\n Data were analyzed using IBM SPSS Statistics software (version 26.0). Chi-square test, unpaired t-test, Mann\u2013Whitney U test, and univariate binary logistic regression analysis were applied.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Final analysis included 141 women (69 premenopausal and 72 postmenopausal). Postmenopausal females had significantly higher body mass index and lower bone mineral density (\n P<\/jats:italic>\n < 0.05). Mean ECBL was significantly greater in postmenopausal females (1.20 \u00b1 0.78 mm) than in premenopausal females (0.65 \u00b1 0.51 mm;\n P<\/jats:italic>\n < 0.001), with critical ECBL (>0.5 mm) observed in 84.7% and 44.9% of participants, respectively. No genetic associations were identified in premenopausal females. In postmenopausal females, IL1A 889 AG (odds ratio (OR) = 7.75;\n P<\/jats:italic>\n = 0.044) and IL6 572 CC genotypes (OR = 8.96;\n P<\/jats:italic>\n = 0.045) were significantly associated with critical ECBL.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Postmenopausal females exhibited significantly greater ECBL around dental implants, and IL1A 889 and IL6 572 polymorphisms showed a significant association with increased ECBL. These findings highlighted the influence of IL1A 889 and IL6 572 gene polymorphisms on early peri implant bone remodeling in postmenopausal females.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jips.jips_588_25","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:15:07Z","timestamp":1782882907000},"page":"252-259","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association of menopausal status and genetic polymorphisms with early crestal bone loss around dental implants: A prospective observational study"],"prefix":"10.4103","volume":"26","author":[{"given":"Kaushal Kishor","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Crowns and Bridges, King George\u2019s Medical University, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Autonomous State Medical College, Gonda, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husbana","family":"Bakrolwala","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Crowns and Bridges, King George\u2019s Medical University, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"R1-20260701","doi-asserted-by":"crossref","first-page":"73","DOI":"10.14219\/jada.archive.2002.0025","article-title":"The physiology, medical management and oral implications of menopause","volume":"133","author":"Friedlander","year":"2002","journal-title":"J Am Dent Assoc"},{"key":"R2-20260701","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1053\/joms.2001.27515","article-title":"Influence of estrogen status on endosseous implant osseointegration","volume":"59","author":"August","year":"2001","journal-title":"J Oral Maxillofac Surg"},{"key":"R3-20260701","first-page":"13","article-title":"Effects of menopause on maxillary bones and dental implant survival","volume":"10","author":"De Oliveira","year":"2021","journal-title":"Res Soc Dev"},{"key":"R4-20260701","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.joms.2024.01.015","article-title":"Menopause-associated changes in mandibular bone microarchitecture are site-specific","volume":"82","author":"Levit","year":"2024","journal-title":"J Oral Maxillofac Surg"},{"key":"R5-20260701","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11657-011-0058-8","article-title":"Influence of menopause on mandibular bone quantity and quality in Japanese women receiving dental implants","volume":"6","author":"Munakata","year":"2011","journal-title":"Arch Osteoporos"},{"key":"R6-20260701","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/prd.12532","article-title":"Emerging factors affecting peri-implant bone metabolism","volume":"94","author":"Insua","year":"2024","journal-title":"Periodontol 2000"},{"issue":"Suppl 1","key":"R7-20260701","first-page":"S155","article-title":"A systematic review of survival of single implants as presented in longitudinal studies with a follow-up of at least 10 years","volume":"9","author":"Hjalmarsson","year":"2016","journal-title":"Eur J Oral Implantol"},{"key":"R8-20260701","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1532-849X.1993.tb00393.x","article-title":"Osteoporosis and osseointegration of implants","volume":"2","author":"Baxter","year":"1993","journal-title":"J Prosthodont"},{"key":"R9-20260701","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/13697137.2012.658110","article-title":"Bone loss in premenopausal, perimenopausal and postmenopausal women: Results of a prospective observational study over 9 years","volume":"15","author":"Seifert-Klauss","year":"2012","journal-title":"Climacteric"},{"key":"R10-20260701","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/cid.12493","article-title":"Does osteoporosis influence the marginal peri-implant bone level in female patients? A cross-sectional study in a matched collective","volume":"19","author":"Wagner","year":"2017","journal-title":"Clin Implant Dent Relat Res"},{"key":"R11-20260701","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1097\/SCS.0b013e3182108ec9","article-title":"Dental implants in patients with osteoporosis: A clinical reality?","volume":"22","author":"Gaetti-Jardim","year":"2011","journal-title":"J Craniofac Surg"},{"key":"R12-20260701","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.prosdent.2015.11.002","article-title":"Crestal bone loss around submerged and nonsubmerged dental implants: A systematic review","volume":"115","author":"Al Amri","year":"2016","journal-title":"J Prosthet Dent"},{"key":"R13-20260701","doi-asserted-by":"crossref","first-page":"49","DOI":"10.14219\/jada.archive.1993.0225","article-title":"Systemic osteoporosis and oral bone loss: Evidence shows increased risk factors","volume":"124","author":"Jeffcoat","year":"1993","journal-title":"J Am Dent Assoc"},{"key":"R14-20260701","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1507\/endocrj.EJ13-0308","article-title":"Association between osteoprotegerin genetic variants and osteoporosis in Chinese postmenopausal women","volume":"60","author":"Yu","year":"2013","journal-title":"Endocr J"},{"key":"R15-20260701","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3390\/genes9090444","article-title":"Can genetic factors compromise the success of dental implants? A systematic review and meta-analysis","volume":"9","author":"Santiago Junior","year":"2018","journal-title":"Genes (Basel)"},{"key":"R16-20260701","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.3390\/pathogens10121600","article-title":"Association between interleukin-1 polymorphisms and susceptibility to dental peri-implant disease: A meta-analysis","volume":"10","author":"Mohammadi","year":"2021","journal-title":"Pathogens"},{"key":"R17-20260701","first-page":"313","article-title":"Associations among gene polymorphisms, crestal bone loss, and bone mineral density in patients receiving dental implants","volume":"19","author":"Agrawal","year":"2024","journal-title":"J Taibah Univ Med Sci"},{"key":"R18-20260701","first-page":"8287026","article-title":"Lack of association between interleukin-1\u03b2 gene polymorphism (rs16944) and chronic periodontitis: From a case-control studies to an updated meta-analysis","author":"Hong","year":"2018","journal-title":"Dis Markers 2018"},{"key":"R20-20260701","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bone.2007.09.056","article-title":"Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi study","volume":"42","author":"Nakamura","year":"2008","journal-title":"Bone"},{"key":"R21-20260701","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4103\/2230-8210.109659","article-title":"Dual energy X-ray absorptiometry: Pitfalls in measurement and interpretation of bone mineral density","volume":"17","author":"Garg","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"key":"R22-20260701","first-page":"403","article-title":"Flapless versus flapped implant insertion in patients with controlled type 2 diabetes subjected to delayed loading: 1-year follow-up results from a randomised controlled trial","volume":"10","author":"Agrawal","year":"2017","journal-title":"Eur J Oral Implantol"},{"key":"R23-20260701","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1902\/jop.2010.100318","article-title":"Three-dimensional measurement of bone loss at implants in patients with periodontal disease","volume":"82","author":"Kehl","year":"2011","journal-title":"J Periodontol"},{"key":"R24-20260701","first-page":"3848207","article-title":"Accuracy of bone measurements in the vicinity of titanium implants in CBCT data sets: A comparison of radiological and histological findings in minipigs","author":"Gr\u00f6be","year":"2017","journal-title":"Biomed Res Int 2017"},{"key":"R25-20260701","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.prosdent.2021.05.023","article-title":"Association of interleukin-1, interleukin-6, collagen type I alpha 1, and osteocalcin gene polymorphisms with early crestal bone loss around submerged dental implants: A nested case control study","volume":"129","author":"Agrawal","year":"2023","journal-title":"J Prosthet Dent"},{"key":"R27-20260701","doi-asserted-by":"crossref","first-page":"S1316","DOI":"10.4103\/jpbs.jpbs_2010_24","article-title":"Association between age of menopause and thickness of crestal cortical bone at dental implant site: A cross-sectional observational study","volume":"17","author":"Kumar","year":"2025","journal-title":"J Pharm Bioallied Sci"},{"key":"R28-20260701","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/jbmr.1860","article-title":"Premenopausal and postmenopausal differences in bone microstructure and mechanical competence in Chinese-American and white women","volume":"28","author":"Walker","year":"2013","journal-title":"J Bone Miner Res"},{"key":"R29-20260701","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/ID.0000000000000405","article-title":"Buccal bone thickness in the esthetic zone of postmenopausal women: A CBCT analysis","volume":"25","author":"Zhang","year":"2016","journal-title":"Implant Dent"},{"key":"R30-20260701","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1631\/jzus.B0920279","article-title":"Interleukin-6 polymorphisms modify the risk of periodontitis: A systematic review and meta-analysis","volume":"10","author":"Shao","year":"2009","journal-title":"J Zhejiang Univ Sci B"},{"key":"R31-20260701","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.3390\/ijms25042146","article-title":"The role of interleukin 6 in periodontitis and its complications","volume":"25","author":"Mazurek-Mochol","year":"2024","journal-title":"Int J Mol Sci"},{"key":"R32-20260701","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.actbio.2024.11.040","article-title":"Obesity prolongs the pro-inflammatory response and attenuates bone healing on titanium implants","volume":"192","author":"Avery","year":"2025","journal-title":"Acta Biomater"}],"container-title":["The Journal of Indian Prosthodontic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/jips.jips_588_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:52:14Z","timestamp":1782928334000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/jips.jips_588_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jips.jips_588_25","relation":{},"ISSN":["0972-4052","1998-4057"],"issn-type":[{"value":"0972-4052","type":"print"},{"value":"1998-4057","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}