{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:30:01Z","timestamp":1786728601757,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anemia of chronic disease (ACD) is the cytokine-mediated outcome of chronic inflammatory disorders. The present study was conducted to assess the hematological parameters in tobacco-associated periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:bold>s<\/jats:bold>\n                      tudy included 120 males, aged 35\u201365 years. Out of total cases, 90 had periodontitis, and they were subdivided into Group I (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 30): tobacco smoker (s), Group II (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 30): tobacco chewer (s), Group III (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 30): tobacco chewer (s) and smoker (s), and Group IV or control (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 30): subjects without periodontitis and tobacco habits. After clinical examination, periodontitis was assessed using plaque index (PI), probing pocket depth (PD), gingival index (GI), and clinical attachment loss (CAL). Blood investigations, including hemoglobin, mean corpuscular hemoglobin (MCH), erythrocyte count, MCH concentration (MCHC), erythrocyte sedimentation rate (ESR), packed cell volume, serum ferritin, transferrin saturation, and total iron-binding capacity (TIBC), were also done.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Group III revealed the highest red blood cell (RBC) count, MCHC, hematocrit, MCH, TIBC, and transferrin saturation. A significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) relation was found between study groups and controls in relation to RBC, ESR, serum ferritin, TIBC, and transferrin saturation. PI and PD scores were highest in Group III; GI and CAL scores were highest in Groups I and II, respectively. All periodontal parameters of the study groups were found significantly (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) different from controls, except for the GI score in Groups II and III.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study revealed that periodontitis should be considered as the causative factor for ACD. Thus, it is required to counsel patients regarding tobacco cessation for the effective management of periodontal diseases and controlling ACD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisp.jisp_211_25","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:00:20Z","timestamp":1778684420000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the relationship between periodontitis and anemia of chronic disease \u2013 A comparative study in smokers and smokeless tobacco users"],"prefix":"10.4103","volume":"30","author":[{"given":"Pradhuman","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology\/Oral Pathology, Dr. Ziauddin Ahmad Dental College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika 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