{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:11:32Z","timestamp":1788361892254,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The present study was intended to comparatively assess the efficacy of ganglioside polymeric nanoparticle-coated 0.25% satranidazole-loaded nanoparticles in gel form with that of the commercially available 1% metronidazole gel as a local drug delivery (LDD) agent for the treatment of periodontal pockets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A split-mouth randomized clinical trial was carried out in 46 chronic periodontitis patients with probing pocket depth (PPD) \u22654 mm or clinical attachment loss greater than 3 mm on both quadrants of the same arch. Full-mouth scaling and root planing (SRP) was performed for all the patients followed by application of 0.25% satranidazole-loaded nanoparticles in gel form on one site (Group 1) and commercially available 1% metronidazole gel on another site (Group 2). Clinical parameters (gingival index, plaque index, PPD, clinical attachment level gain, and bleeding on probing) and microbiological analysis of the subgingival plaque samples were performed and assessed at baseline, after SRP, 21\n                      <jats:sup>st<\/jats:sup>\n                      day, and 90\n                      <jats:sup>th<\/jats:sup>\n                      day post treatment. Unpaired \u201c\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      \u201d-test and ANOVA tests were used for intergroup and intragroup comparison of recorded parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results showed that the satranidazole-loaded nanoparticle group as an adjunct to SRP in chronic periodontitis showed a statistically significant improvement in all the clinical parameters and a fewer relapse of microbial flora in comparison with the metronidazole group as an LDD agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The present study depicted that both the LDD agents showed an effective improvement of clinical as well as microbiological parameters, but the satranidazole group consistently produced better results than the metronidazole group and hence has a promising future as an LDD agent in treating periodontal pockets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisp.jisp_233_21","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T01:12:10Z","timestamp":1661476330000},"page":"378-383","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["A new era of Nano!!! Comparative evaluation of ganglioside polymeric nanoparticle coated satranidazole gel and 1% metronidazole gel for the treatment of periodontitis"],"prefix":"10.4103","volume":"26","author":[{"given":"Shivam","family":"Kesarwani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Parihar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Meraj","family":"Anjum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240828","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"R3-12-20240828","doi-asserted-by":"crossref","first-page":"S252","DOI":"10.4103\/0975-7406.100226","article-title":"Antibiotics in the management of aggressive periodontitis","volume":"4","author":"Prakasam","year":"2012","journal-title":"J Pharm Bioallied Sci"},{"key":"R5-12-20240828","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1007\/s10620-006-9111-7","article-title":"Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess","volume":"51","author":"Muzaffar","year":"2006","journal-title":"Dig Dis Sci"},{"key":"R6-12-20240828","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/jac\/15.4.463","article-title":"Satranidazole: Experimental evaluation of activity against anaerobic bacteria in vitro and in animal models of anaerobic infection","volume":"15","author":"Gowrishankar","year":"1985","journal-title":"J Antimicrob Chemother"},{"key":"R7-12-20240828","doi-asserted-by":"crossref","first-page":"47659","DOI":"10.1039\/C5RA02350E","article-title":"Mucoadhesive gel containing immunotherapeutic nanoparticulate satranidazole for treatment of periodontitis: Development and its clinical implications","volume":"5","author":"Singh","year":"2015","journal-title":"RSC Adv"},{"key":"R8-12-20240828","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0378-5173(89)90281-0","article-title":"Nanocapsule formation by interfacial polymer deposition following solvent displacement","volume":"55","author":"Fessi","year":"1989","journal-title":"Int J Pharm"},{"key":"R9-12-20240828","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1166\/jbn.2013.1580","article-title":"Development of lipid nanoparticles of diacerein, an antiosteoarthritic drug for enhancement in bioavailability and reduction in its side effects","volume":"9","author":"Jain","year":"2013","journal-title":"J Biomed Nanotechnol"},{"key":"R10-12-20240828","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/10426500290095601","article-title":"Development and physical characterization of a periodontal bioadhesive gel of metronidazole","volume":"9","author":"Varshosaz","year":"2002","journal-title":"Drug Deliv"},{"key":"R11-12-20240828","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy. 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