{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:22:06Z","timestamp":1787757726908,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      A randomized controlled clinical trial was conducted to evaluate the effect of local drug delivery (LDD) of\n                      <jats:italic toggle=\"yes\">Acmella oleracea (Akarkara) and Acacia catechu (kattha) gels<\/jats:italic>\n                      as an adjunct to scaling and root planing (SRP) in generalized chronic periodontitis patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Thirty patients with ninety sites aged 25\u201365 years with generalized chronic periodontitis having pocket probing depth (PPD) of more than or equal to 5 mm on the basis of inclusion and exclusion criteria were selected. They were treated according to split-mouth design protocol. The placement of gel containing\n                      <jats:italic toggle=\"yes\">A. oleracea<\/jats:italic>\n                      (1%) (Group 1) and\n                      <jats:italic toggle=\"yes\">A. catechu<\/jats:italic>\n                      (1%) (Group 2) as LDD was placed at the two test sites, respectively, and only SRP was done in the control group (Group 3). Periodontal dressing was applied to all the three sites after procedure, and patients were given oral care guidelines. Evaluation of clinical parameters gingival index (GI), plaque index (PI), gingival bleeding index (GBI), PPD, clinical attachment level (CAL), and relative attachment level (RAL) was done at baseline, 1, 3, and 6 months, and microbiological parameter was assessed at baseline and 6 months. N-benzoyl-DL-arginine-2-napthylamide (BANA) test was used for the microbiological analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Clinical parameters from baseline to 6 months at different time intervals demonstrated a significant reduction in mean GI, PI, GBI, and PPD and gain in CAL and RAL over a period of 6 months, and results were statistically significant in all the three treatment groups. However, on intergroup comparison, clinically significant difference was observed, but statistically, results were significant at few intervals. The microbiological analysis revealed a statistically nonsignificant reduction at the end of 6 months on intra- and intergroup comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The study concluded that the use of\n                      <jats:italic toggle=\"yes\">A. catechu<\/jats:italic>\n                      gel and\n                      <jats:italic toggle=\"yes\">A. oleracea<\/jats:italic>\n                      gel clinically showed improvement in clinical parameters when combined with SRP, attributing to better anti-inflammatory and healing properties.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisp.jisp_264_21","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T23:10:37Z","timestamp":1651446637000},"page":"254-261","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["A clinical and microbiological study to assess the efficacy of Acmella oleracea and Acacia catechu herbs as local drug delivery in treatment of chronic generalized periodontitis patients"],"prefix":"10.4103","volume":"26","author":[{"given":"Kanika","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Dhruvakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind","family":"Pande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20240828","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1600-051X.1979.tb02186.x","article-title":"Periodontal therapy by local delivery of tetracycline","volume":"6","author":"Goodson","year":"1979","journal-title":"J Clin Periodontol"},{"key":"R2-11-20240828","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/0972-124X.92559","article-title":"Effect of local drug delivery in chronic periodontitis patients: A meta-analysis","volume":"15","author":"Kalsi","year":"2011","journal-title":"J Indian Soc Periodontol"},{"key":"R3-11-20240828","first-page":"30","article-title":"Local drug delivery in periodontics: A strategic intervention","volume":"4","author":"Dodwad","year":"2004","journal-title":"Inter J Pharm Sci"},{"key":"R4-11-20240828","first-page":"41","article-title":"Chair side therapeutic aids in periodontics","volume":"3","author":"Baiju","year":"2010","journal-title":"Heal Talk"},{"key":"R5-11-20240828","doi-asserted-by":"crossref","first-page":"602","DOI":"10.4236\/ajps.2017.83041","article-title":"Conservation status and therapeutic potential of Saussurea lappa: An overview","volume":"8","author":"Amara","year":"2017","journal-title":"Am J Plan Sci"},{"key":"R6-11-20240828","first-page":"109","article-title":"Notes on traditional uses of Khair (A. catechu Wild) by inhabitants of Shivalik range of western Himalaya, Ethnobotanical Leaflets","volume":"10","author":"Singh","year":"2006","journal-title":"Int J Eth Res"},{"key":"R7-11-20240828","doi-asserted-by":"crossref","first-page":"475","DOI":"10.13005\/ojc\/290211","article-title":"Qualitative and quantitative analysis of phytochemicals and pharmacological value of some dye yielding medicinal plants","volume":"29","author":"Gupta","year":"2013","journal-title":"Orient J Chem"},{"key":"R8-11-20240828","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4103\/0253-7613.28207","article-title":"Antipyretic, anti-diarrhoeal, hypoglycaemic and hepatoprotective activities of ethyl acetate extract of Acacia catechu wild. 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