{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:03Z","timestamp":1786649523972,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"\n Background:<\/jats:title>\n \n The therapeutic potential of herbs in treating various diseases is gaining recognition due to their promising outcomes and minimal side effects. One such herb,\n Nigella sativa<\/jats:italic>\n , is renowned for its medicinal properties, particularly due to its extract, Thymoquinone (TQ), which demonstrates anti-inflammatory, anti-oxidant, antimicrobial, analgesic, and immune-modulating effects. Green synthesis methods for nano-sized particles are considered environmentally friendly and have been proven effective given their size, higher surface-to-volume ratio, and enhanced physical and mechanical properties. This study aims to investigate a novel approach in the green synthesis of silver nanoparticles of\n Nigella sativa<\/jats:italic>\n and 0.1% TQ and to assess their anti-inflammatory and antioxidant activities\n <\/jats:p>\n <\/jats:sec>\n \n . Materials and Methods:<\/jats:title>\n \n The seeds of NS were used to green synthesize silver nanoparticles. The anti-inflammatory effects of the green synthesized particles were tested using egg albumin and bovine serum assays, and their anti-oxidant actions were assessed using 2,2-Diphenyl-1-picrylhydrazyl denaturation assay and H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n assay.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The novel formulation of\n Nigella sativa<\/jats:italic>\n -mediated silver nanoparticles with 0.1% TQ exhibits 76% anti-inflammatory activity and 80%\u201387% anti-oxidant properties.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Our results suggest that the silver nanoparticles mediated from\n N. sativa<\/jats:italic>\n with 0.1% TQ extract could serve as an effective herbal adjunct for treating periodontal infections because of its potent anti-inflammatory and anti-oxidant properties.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jisp.jisp_278_24","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T05:01:05Z","timestamp":1749618065000},"page":"57-62","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Green synthesis of silver nanoparticles using Nigella sativa with 0.1% of thymoquinone and evaluation of its anti-inflammatory and antioxidant activities \u2013 An in vitro study"],"prefix":"10.4103","volume":"29","author":[{"given":"Leslie Rani","family":"Sthanislas","sequence":"first","affiliation":[{"name":"Department of Periodontology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bagavad Gita","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautham Kumar","family":"Nandhakumar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowri Shankar","family":"Nattuthurai","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menaka","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savithri Nediyaparambu","family":"Krishnakumar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noblin","family":"Shyma","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1177\/0022034510375830","article-title":"Oxidative stress, systemic inflammation, and severe periodontitis","volume":"89","author":"D\u2019Aiuto","year":"2010","journal-title":"J Dent Res"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1902\/jop.2009.080509","article-title":"N-acetylcysteine, a thiol antioxidant, decreases alveolar bone loss in experimental periodontitis in rats","volume":"80","author":"Toker","year":"2009","journal-title":"J Periodontol"},{"key":"R4-20260422","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5455\/jice.20160122065556","article-title":"Herbs as an antioxidant arsenal for periodontal diseases","volume":"5","author":"Ramesh","year":"2016","journal-title":"J Intercult Ethnopharmacol"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/1528635","article-title":"Nigella sativa L. 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