{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:52:48Z","timestamp":1788317568782,"version":"build-2803163510"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Simvastatin (SMV) is used for the treatment of hypercholesterolemia. Long-term systemic administration of SMV has been shown to result in increased bone mineral density. Alendronate (ALN) is known to inhibit osteoclastic bone resorption and has osteostimulative properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To compare percentile changes in gain in clinical attachment level and reduction of pocket depth, and to radiographically evaluate osseous defect fill with subgingival local drug delivery of 1.2% SMV gel and 1% ALN gel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A split-mouth study was conducted with 40 infrabony defects from 20 patients diagnosed with chronic periodontitis. The sites were assigned as test site 1 (SMV gel) or test site 2 (ALN gel). After phase I therapy, a single application of SMV gel or ALN gel was done into periodontal pockets. Clinical periodontal parameters and percentage of bone fill were evaluated at baseline, 3 and 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There was a statistically significant reduction in pocket depth, plaque index, and bleeding index scores, gain in Clinical attachment level (CAL) and bone defect fill from baseline to 6 months at both sites. On comparison between the groups, test site 2 showed significant improvement in clinical attachment level than in test site 1 at 6-month follow-up. Test site 2 showed more percentage bone fill than test site 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Usage of both SMV and ALN gels in periodontal intra bony defects can lead to significant improvements in clinical and radiographic parameters; however, ALN showed better osseous defect fill.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisp.jisp_37_22","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T09:25:50Z","timestamp":1670232350000},"page":"591-599","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of simvastatin 1.2% gel and alendronate 1% gel in chronic periodontitis as local drug delivery: A randomized clinical trial"],"prefix":"10.4103","volume":"26","author":[{"given":"Bhavya","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Karegowda","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safiya Fatima","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh","family":"Yadalam","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjusha","family":"Nambiar","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0765.1986.tb01511.x","article-title":"The role of supragingival plaque in the prevention and treatment of periodontal diseases. 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