{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:30:12Z","timestamp":1786728612389,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>The trend of using herbal bone replacement material for the regeneration of periodontal intrabony defects is still underexplored in clinical periodontal practice. As there remains a paucity in scientific information regarding this, the present study was carried out to evaluate and compare clinically and radiographically the effectiveness of curcumin gel and bioactive glass as a BRM in treating intrabony defects among the South Indian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 60 intrabony defects were randomly divided into Group 1 (30 defects treated with curcumin gel) and Group 2 (30 defects treated with bioactive glass). All clinical and radiographic parameters were recorded at baseline, 3 months, 6 months, and 9 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All the clinical parameters showed statistically significant intragroup and intergroup improvement at the end of 9 months. There was a statistically significant volumetric bone fill of defect sites, which was 13.64 (61.19%) and 11.51 (49.36%) in Groups 1 and 2, respectively, at the end of 9 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The present study indicates that curcumin gel has a great potential for bone regeneration in periodontal intrabony defects, along with minimum\/no postsurgical side effects due to its herbal nature. Thus, it may serve as a natural alternative to synthetic BRMs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisp.jisp_403_24","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:01:32Z","timestamp":1778684492000},"page":"80-86","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A neoteric approach to regeneration of intrabony defects using curcumin gel versus bioactive glass as bone replacement material among South Indian population: A randomized controlled trial"],"prefix":"10.4103","volume":"30","author":[{"given":"Kavita","family":"Chandrasekaran","sequence":"first","affiliation":[{"name":"Department of Periodontology, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India"},{"name":"Department of Physiology, All India Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Kripal","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Kumar D.","family":"Chavan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"R1-20260514","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1902\/jop.1976.47.5.256","article-title":"On the repair potential of periodontal tissues","volume":"47","author":"Melcher","year":"1976","journal-title":"J Periodontol"},{"key":"R2-20260514","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0757.2006.00157.x","article-title":"Biology and principles of periodontal wound healing\/regeneration","volume":"41","author":"Polimeni","year":"2006","journal-title":"Periodontol 2000"},{"key":"R3-20260514","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1902\/jop.1999.70.4.384","article-title":"A bioactive glass particulate in the treatment of molar furcation invasions","volume":"70","author":"Anderegg","year":"1999","journal-title":"J Periodontol"},{"key":"R4-20260514","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jab.770030208","article-title":"Bioactive ceramics for periodontal treatment: Comparative studies in the Patus monkey","volume":"3","author":"Wilson","year":"1992","journal-title":"J Appl Biomater"},{"key":"R5-20260514","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/B978-0-08-042144-5.50025-X","article-title":"Bone growth into spaces between 45S5 bioglass granules","volume":"7","author":"Oonishi","year":"1994","journal-title":"Bioceramics"},{"key":"R6-20260514","first-page":"39","article-title":"Osseous grafting part II: Xenografts and alloplasts for periodontal regeneration-a literature review","volume":"12","author":"AlGhamdi","year":"2010","journal-title":"J Int Acad Periodontol"},{"key":"R7-20260514","article-title":"Periodontal repair using PerioGlas in nonhuman primates: Clinical and histologic observations","volume":"15","author":"Fetner","year":"1994","journal-title":"Compendium"},{"key":"R8-20260514","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0011-8532(22)00579-1","article-title":"Bone replacement grafts. 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