{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:22:37Z","timestamp":1787772157754,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Periodontal bone defects pose significant challenges in dentistry, necessitating effective treatment strategies. This case report explores the regenerative potential of using a combination of particulate dentin graft (PDG) derived from extracted teeth and recombinant human platelet-derived growth factor (rhPDGF) as bone graft material for the treatment of human periodontal infrabony defects. A 44-year-old male patient presented with a 9 mm pocket probing depth (PPD) and an 8 mm infrabony defect depth mesial to #13, with no gingival recession (GR). Following Phase I therapy, open flap debridement and grafting with PDG and rhPDGF were performed. Clinical and radiographic measurements were taken at baseline and 6 and 12 months. At 12 months, a 6 mm reduction in PPD and clinical attachment level gain were observed with no GR. 5 mm (83.33%) bone fill was seen radiographically. Within the limitations of this case report, the utilization of PDG with rhPDGF for the treatment of infrabony periodontal defects has emerged as a promising regenerative therapy.<\/jats:p>","DOI":"10.4103\/jisp.jisp_449_23","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T08:02:33Z","timestamp":1736150553000},"page":"489-493","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet-derived growth factor"],"prefix":"10.4103","volume":"28","author":[{"given":"Vishal","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Implantology, SGT University, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Sciences, SGT University, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"R1-20250108","doi-asserted-by":"crossref","first-page":"272.","DOI":"10.3390\/jfb14050272","article-title":"Dentin, dentin graft, and bone graft: Microscopic and spectroscopic analysis","volume":"14","author":"Minetti","year":"2023","journal-title":"J Funct Biomater"},{"key":"R2-20250108","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s13770-022-00438-4","article-title":"Demineralized dentin matrix for dental and alveolar bone tissues regeneration: An innovative scope review","volume":"19","author":"Grawish","year":"2022","journal-title":"Tissue Eng Regen Med"},{"key":"R3-20250108","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1600-051X.1989.tb02334.x","article-title":"A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration","volume":"16","author":"Lynch","year":"1989","journal-title":"J Clin Periodontol"},{"key":"R4-20250108","first-page":"56","article-title":"A novel procedure to process extracted teeth for immediate grafting of autogenous dentin","volume":"2","author":"Binderman","year":"2014","journal-title":"J Interdiscip Med Dent Sci"},{"key":"R5-20250108","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1034\/j.1600-051X.2003.10192.x","article-title":"Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane. A controlled clinical study","volume":"30","author":"Sculean","year":"2003","journal-title":"J Clin Periodontol"},{"key":"R6-20250108","doi-asserted-by":"crossref","first-page":"1431.","DOI":"10.3390\/ma15041431","article-title":"Autologous dentin graft after impacted mandibular third molar extraction to prevent periodontal pocket formation-a split-mouth pilot study","volume":"15","author":"Mazzucchi","year":"2022","journal-title":"Materials (Basel)"},{"key":"R7-20250108","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3126\/kumj.v18i1.34661","article-title":"Tooth -a potential graft material for periodontal regeneration?","volume":"18","author":"Devani","year":"2020","journal-title":"Kathmandu Univ Med J (KUMJ)"},{"key":"R8-20250108","first-page":"84","article-title":"Regeneration of intrabony defects using autogenous dentin graft \u2013 A case report","volume":"2","author":"Tamloorker","year":"2019","journal-title":"Int J Dent Sci Innov Res"},{"key":"R9-20250108","first-page":"91","article-title":"Bone engineering using human demineralized dentin matrix (autotooth bone graft) in the treatment of human intrabony defects: A case report","volume":"8","author":"Kripal","year":"2017","journal-title":"EC Dent Sci"},{"key":"R10-20250108","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1902\/jop.2003.74.9.1282","article-title":"Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone","volume":"74","author":"Nevins","year":"2003","journal-title":"J Periodontol"},{"key":"R11-20250108","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1902\/jop.2012.120145","article-title":"A systematic review of the use of growth factors in human periodontal regeneration","volume":"84","author":"Darby","year":"2013","journal-title":"J Periodontol"},{"key":"R12-20250108","first-page":"161","article-title":"Recombinant human platelet-derived growth factor: A systematic review of clinical findings in oral regenerative procedures","volume":"6","author":"Tavelli","year":"2021","journal-title":"JDR Clin Trans Res"}],"container-title":["Journal of Indian Society of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jisp.jisp_449_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:31:24Z","timestamp":1787769084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jisp.jisp_449_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jisp.jisp_449_23","relation":{},"ISSN":["0972-124X","0975-1580"],"issn-type":[{"value":"0972-124X","type":"print"},{"value":"0975-1580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-09-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}