{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:23:45Z","timestamp":1790713425998,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Interleukin-17 (IL-17) plays an important function in initiation, progression of any inflammatory condition. It is a pro-inflammatory cytokine and considered to be founding member. Periodontitis being an inflammatory condition of periodontium, IL-17 does have a potential role in periodontitis. The current research has shown positive correlation between the IL-17 and severity of periodontitis. Therefore, this research study aimed to evaluate the levels of IL-17 in aggressive periodontitis (AgP), chronic periodontitis (CP), and \u201chealthy gingival sites.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 45 selected subjects (90 samples) were equally divided into three different groups. Group 1 (Healthy gingiva on clinical examination): Subjects with healthy gingiva and no evidence of periodontal attachment level (PAL), probing pocket depth (PPD) &lt;3 mm papillary bleeding index (PBI) &lt;1. Group 2 (AgP): Subjects having age &lt;35 years with at least six permanent teeth apart from the incisors and first molars with PPD and PAL \u22655 mm. Group 3 (CP): It consist of subjects with clinical features of inflammation of gingiva with minimum six teeth in each jaw, with PPD \u22654 mm, PAL \u22654 mm. IL-17 levels were analyzed by using Gingival crevicular fluid (GCF). It was collected from the sulcus of first maxillary molar sites for quantitative analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      GCF IL-17 levels in AgP were found to be 1.12 \u00b1 0.29, 1.96 \u00b1 1.71 in CP and 0.64 \u00b1 0.23 in healthy gingival sites. Clinical parameters such as (1) plaque index (Turesky\n                      <jats:italic toggle=\"yes\">et al.<\/jats:italic>\n                      , modification of Quigley-Hein), (2) PPD, (3) PBI were higher (significantly) in periodontitis group as compared to healthy gingiva. Positive correlation was found to be significant between levels of IL-17 with PAL and PPD in AgP however in cases of CP, positive correlation of IL-17 levels was found only with PAL but not PPD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study shows that the IL-17 levels were comparatively higher in GCF of AgP, CP in comparison to healthy gingiva, but the GCF IL-17 levels were higher in CP as compared to AgP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisp.jisp_47_21","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T09:25:50Z","timestamp":1670232350000},"page":"552-556","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Interleukin-17 levels in gingival crevicular fluid of aggressive periodontitis and chronic periodontitis patients"],"prefix":"10.4103","volume":"26","author":[{"given":"Anand Narayanrao","family":"Wankhede","sequence":"first","affiliation":[{"name":"Department of Periodontology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Deemed to be University, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad Vijayrao","family":"Dhadse","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Deemed to be University, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"S430","DOI":"10.1016\/j.jaci.2005.09.034","article-title":"1. 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