{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:31:15Z","timestamp":1787070675084,"version":"build-2736575974"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to systematically review the literature regarding the inflammatory profiles, measured by cytokines and chemokines, of individuals with different diagnoses of weight, but with the similar periodontal condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Searches were performed in five databases (Scopus, EMBASE, PubMed, Web of Science, and Cochrane-Central). Studies that compared the inflammatory profile of normal-weight individuals to those with obesity and evaluated the same cytokine, collection method, and periodontal diagnosis (periodontal health, gingivitis, or periodontitis) were included. Cross-sectional studies underwent evaluation by independent researchers using the Joanna Briggs Institute Critical Appraisal Checklist. The GRADE (Grades of Recommendation, Assessment, Development and Evaluation) system assessed evidence certainty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twelve studies were included. The diagnosis of obesity was done on the basis of body mass index, waist circumference, and waist\u2013hip ratio. Pro-inflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor-\u03b1 [TNF]-\u03b1, IL-1\u03b2, IL-31, and IL-34) were analyzed in serum, saliva, gingival crevicular fluid (GCF), and plasma. Periodontal diagnoses varied across studies. TNF-\u03b1 expression was significantly higher in individuals with obesity and periodontal health or periodontitis. Serum IL-1\u03b2 levels showed mixed results, but salivary IL-1\u03b2 levels were elevated in obese individuals. IL-6 levels were higher in obese individuals, regardless of periodontal status. IL-34 and IL-10 showed no significant differences across groups. Monocyte chemoattractant protein-4 (MCP-4) levels were higher in obese individuals with periodontitis or periodontal health. IL-31 and IL-34 in GCF showed no significant differences between obese and nonobese individuals, without periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Heterogeneous results were noted for IL-6, IL-1\u03b2, IL-31, IL-34, TNF-\u03b1, and MCP-4, hindering conclusions on weight\u2019s impact on inflammatory profiles in periodontal patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisp.jisp_511_23","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T17:51:00Z","timestamp":1717523460000},"page":"32-42","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory profile of patients with different weight diagnoses and similar periodontal condition: A systematic review"],"prefix":"10.4103","volume":"28","author":[{"given":"Juliana dos 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