{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:30:55Z","timestamp":1787758255300,"version":"build-2784847793"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Matrix metalloproteinases (MMPs) are a major group of enzymes, released in inflamed periodontal tissues in large quantities, resulting in connective tissue matrix breakdown. One of the most predominant MMPs is MMP-9. Association between chronic periodontitis (CP) and MMP-9 gene polymorphism (GP) in some ethnic populations has been already established. The aim of the current study was to assess the association of single-nucleotide polymorphism in the promoter region of MMP-9 gene with CP in Kolkata population, if any.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Forty eligible individuals were recruited for the study and grouped as A and B: Group A (twenty periodontally healthy individuals) and Group B (twenty CP patients). Venous blood samples collected from all the forty individuals were used to isolate the genomic DNA. GP for MMP-9 gene was detected using polymerase chain reaction and sequencing method. The data obtained were then analyzed statistically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A significantly different genotypic and allelic variation was observed in the control and test groups, with C\/T genotype and T allele present in only CP group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Within the limitations of this study, we can conclude that there was no significant association between patients with periodontitis and MMP-9-1562 C\/T promoter GP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisp.jisp_80_21","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T01:12:10Z","timestamp":1661476330000},"page":"348-352","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Matrix metalloproteinase-9-1562 C\/T promoter gene polymorphism in chronic periodontitis"],"prefix":"10.4103","volume":"26","author":[{"given":"Puja","family":"Sarkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamil Selvan","family":"Muthuraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanta","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papita","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-7-20240828","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.0906-6713.2002.03202.x","article-title":"Understanding the etiology of periodontitis: An overview of periodontal risk factors","volume":"32","author":"Nunn","year":"2003","journal-title":"Periodontol 2000"},{"key":"R3-7-20240828","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12047","article-title":"Modifiable risk factors in periodontitis: At the intersection of aging and disease","volume":"64","author":"Reynolds","year":"2014","journal-title":"Periodontol 2000"},{"key":"R4-7-20240828","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1902\/annals.2001.6.1.91","article-title":"The relationship between periodontal diseases and diabetes: An overview","volume":"6","author":"Soskolne","year":"2001","journal-title":"Ann Periodontol"},{"key":"R5-7-20240828","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1902\/annals.2001.6.1.99","article-title":"Bidirectional interrelationships between diabetes and periodontal diseases: An epidemiologic perspective","volume":"6","author":"Taylor","year":"2001","journal-title":"Ann Periodontol"},{"key":"R6-7-20240828","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0757.2012.00455.x","article-title":"Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: A shared pathology via oxidative stress and mitochondrial dysfunction?","volume":"64","author":"Bullon","year":"2014","journal-title":"Periodontol 2000"},{"key":"R7-7-20240828","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-0757.1997.tb00190.x","article-title":"The microbial challenge in periodontitis","volume":"14","author":"Darvean","year":"1997","journal-title":"Periodontol 2000"},{"key":"R8-7-20240828","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1902\/annals.1998.3.1.88","article-title":"Cigarette smoking and periodontal diseases: Etiology and management of disease","volume":"3","author":"Tonetti","year":"1998","journal-title":"Ann Periodontol"},{"key":"R9-7-20240828","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S1286-4579(02)01642-8","article-title":"Genetic susceptibility to chronic periodontal disease","volume":"4","author":"Baker","year":"2002","journal-title":"Microbes Infect"},{"key":"R10-7-20240828","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1902\/jop.1994.65.5s.479","article-title":"Genetic and heritable risk factors in periodontal disease","volume":"65","author":"Michalowicz","year":"1994","journal-title":"J Periodontol"},{"key":"R11-7-20240828","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1902\/jop.1993.64.12.1205","article-title":"Self-reported periodontal disease in a Virginia twin population","volume":"64","author":"Corey","year":"1993","journal-title":"J Periodontol"},{"key":"R12-7-20240828","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1177\/0022034519842510","article-title":"What is the heritability of periodontitis? 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