{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:52Z","timestamp":1787840452310,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periodontal disease is suspected to play a causal role in adverse pregnancy outcomes like preeclampsia, which is a serious complication of end-stage pregnancy. This study investigated the periodontal status of immediate postpartum women with preeclampsia and compared it with women with normal uncomplicated pregnancy and childbirth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The primary aim is to determine the risk of association between maternal periodontal disease and preeclampsia. The secondary outcome is determining whether C-reactive protein (CRP) levels are a potential mediator of this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective case\u2013control study was conducted during a 1-year period among 200 postpartum women with preeclampsia complications and normal gestation on a 1:1 ratio. All the study participants were examined by a qualified periodontist within 48 h postpartum to assess periodontal status and 5 ml of blood drawn for estimation of CRP levels. This correlation was assessed using Spearman\u2019s correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Statistical analysis by Pearson\u2019s Chi-square test and Spearman\u2019s rank correlation showed 46% of the study population had chronic periodontitis, out of which 7% had nonsevere preeclampsia without complications and 3% had severe life-threatening preeclampsia with complications (odds ratio 2.49, confidence interval 95%\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). Furthermore, both the gestational period and mean birth weight decreased with the increasing severity of periodontitis. The increase in CRP levels was positively correlated, as shown by the one-way ANOVA with both periodontitis and preeclampsia, along with gestational period and birth weight of infants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>After adjusting for other risk factors, there is a significant association between maternal periodontitis and preeclampsia complications and a significant correlation between increased CRP levels, increasing severity of periodontitis, and mean birth weight. As periodontitis is a treatable disease. severe adverse pregnancy complication like preeclampsia can be prevented with early diagnosis and management of periodontal health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisp.jisp_85_24","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T11:00:57Z","timestamp":1755774057000},"page":"123-129","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Significant association between maternal periodontitis and pre-eclampsia complications \u2013 A retrospective case control study"],"prefix":"10.4103","volume":"29","author":[{"given":"P. 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