{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:36:03Z","timestamp":1787070963733,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Int Soc Prev Community Dent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>bstract<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Root caries (RC) is a significant concern in older adults. Oxidative stress and dietary factors may play a role in its development and progression. However, the interactive effects of dietary total antioxidant capacity (dTAC) and RC severity (RCS) on salivary oxidative status in this population are not fully understood. This study aimed to assess dietary and salivary oxidative status and to investigate the interactive effect of RCS and dTAC on salivary total antioxidant capacity (TAC) and total oxidative status (TOS) in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A case\u2013control study was conducted with 90 participants aged 50\u201360 years recruited from a university dental hospital. Participants were allocated into six groups (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 15\/group) based on dTAC (high\/low) and RCS (none, incipient, and shallow). dTAC was measured using the ferric reducing-antioxidant power assay. Salivary TAC and TOS levels were measured using colorimetric kits. RCS was clinically diagnosed. Data were analyzed using two-way analysis of variance (ANOVA), two-way multivariate ANOVA, and Pearson\u2019s correlation coefficient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Salivary TAC was significantly higher in participants with high dTAC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) and increased with increasing RCS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Salivary TOS was lower in those with high dTAC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) and increased with increasing RCS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). A significant interactive effect of RCS and dTAC on both TAC and TOS was observed (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both dietary TAC and RC S have significant, independent, and interactive effects on salivary oxidative status among older adults. A diet high in antioxidants may improve salivary oxidative status and potentially mitigate the severity of RC. Dietary interventions aimed at increasing antioxidant intake may be a valuable adjunct to conventional RC prevention strategies in older adults. Further research should explore the long-term impact of dietary antioxidants on RC incidence and progression, and investigate specific antioxidant compounds and their mechanisms of action in larger, more diverse populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jispcd.jispcd_116_24","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T13:00:09Z","timestamp":1755262809000},"page":"364-373","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Dietary and Salivary Oxidative Status Related to Root Caries Severity: A Case\u2013Control Study"],"prefix":"10.4103","volume":"15","author":[{"given":"Baydaa Ahmed","family":"Yas","sequence":"first","affiliation":[{"name":"Department of Pedodontic, Orthodontics and Preventive Dentistry, College of Dentistry, Uruk University, Baghdad, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"CIT0001-20250902","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.4103\/JCDE.JCDE_506_24","article-title":"Root caries: Prevalence, risk indicators, and clinical characteristics \u2013 A cross-sectional study","volume":"27","author":"Shetty","year":"2024","journal-title":"J Conserv Dent Endod"},{"key":"CIT0002-20250902","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3390\/antiox12061309","article-title":"Benefits of natural antioxidants on oral health","volume":"12","author":"Malcangi","year":"2023","journal-title":"Antioxidants"},{"key":"CIT0003-20250902","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.3390\/jcm13133781","article-title":"Impact of periodontitis on endothelial risk dysfunction and oxidative stress improvement in patients with cardiovascular disease","volume":"13","author":"Angjelova","year":"2024","journal-title":"J Clin Med"},{"key":"CIT0004-20250902","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/antiox12020330","article-title":"Dental caries and salivary oxidative stress: Global scientific research landscape","volume":"12","author":"de Sousa N\u00e9","year":"2023","journal-title":"Antioxidants"},{"key":"CIT0005-20250902","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4103\/MJBL.MJBL_333_22","article-title":"Investigation of the salivary antioxidants and oxidative damage among smokers and non-smokers with dental caries","volume":"20","author":"Oda","year":"2023","journal-title":"Med J Babylon"},{"key":"CIT0006-20250902","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.3390\/diagnostics13243648","article-title":"Total antioxidant capacity of saliva and its correlation with pH levels among dental students under different stressful conditions","volume":"13","author":"Schwarz","year":"2023","journal-title":"Diagnostics"},{"key":"CIT0007-20250902","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4103\/jispcd.JISPCD_186_22","article-title":"Interactive effect of salivary protein carbonyl, total glutathione, pH, and flow rate on root caries severity: A case\u2013control study","volume":"13","author":"Yas","year":"2023","journal-title":"J Int Soc Prev Community Dent"},{"key":"CIT0008-20250902","doi-asserted-by":"crossref","first-page":"716359","DOI":"10.3389\/fimmu.2021.716359","article-title":"Estimating the effects of dental caries and its restorative treatment on periodontal inflammatory and oxidative status: A short controlled longitudinal study","volume":"12","author":"Kanjevac","year":"2021","journal-title":"Front Immunol"},{"key":"CIT0009-20250902","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.14219\/jada.archive.2008.0353","article-title":"Measuring salivary flow","volume":"139","author":"Navazesh","year":"2014","journal-title":"J Am Dent Assoc"},{"key":"CIT0010-20250902","first-page":"152","article-title":"Measuring dental diseases: A critical review of indices in dental practice and research","volume":"16","author":"Ramanarayanan","year":"2020","journal-title":"Amrita J Am"},{"key":"CIT0011-20250902","doi-asserted-by":"crossref","first-page":"199","DOI":"10.12968\/denu.2020.47.3.199","article-title":"Root caries part 2: The restorative challenge","volume":"47","author":"Burrows","year":"2020","journal-title":"Dent Update"},{"key":"CIT0012-20250902","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3390\/dj10070138","article-title":"Prevalence of dental caries in children in Mymensingh and its associated risk factors: A cross-sectional study","volume":"10","author":"Sultana","year":"2022","journal-title":"Dent J"},{"key":"CIT0014-20250902","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: The FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal Biochem"},{"key":"CIT0015-20250902","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1475-2891-9-3","article-title":"The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide","volume":"9","author":"Carlsen","year":"2010","journal-title":"Nutr J"},{"key":"CIT0016-20250902","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3390\/antiox10101540","article-title":"Salivary oxidative stress markers\u2019 relation to oral diseases in children and adolescents","volume":"10","author":"Salman","year":"2021","journal-title":"Antioxidants"},{"key":"CIT0017-20250902","doi-asserted-by":"crossref","first-page":"390","DOI":"10.4103\/jiaomr.jiaomr_109_22","article-title":"Evaluating the role of salivary oxidative stress marker malondialdehyde in dental caries\u2014A comparative study","volume":"34","author":"Sivaranjani","year":"2022","journal-title":"J Indian Acad Oral Med Radiol"},{"key":"CIT0018-20250902","first-page":"266","article-title":"Salivary oxidative stress, total protein, iron and pH in children with \u03b2-thalassemia major and their correlation with dental caries","volume":"23","author":"Akbarnejad","year":"2022","journal-title":"J Dent (Shiraz)"},{"key":"CIT0019-20250902","doi-asserted-by":"crossref","first-page":"105521","DOI":"10.1016\/j.jdent.2024.105521","article-title":"Atraumatic restorative treatment induces transient changes in salivary total protein and redox biomarkers in children with caries: A non-randomized clinical study","volume":"153","author":"Lopes","year":"2025","journal-title":"J Dent"},{"key":"CIT0020-20250902","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1515\/tjb-2022-0009","article-title":"Relationship between dental caries and saliva\u2019s visfatin levels, total antioxidant capacity (TAC) and total oxidant status (TOS)","volume":"47","author":"Hataysal","year":"2022","journal-title":"Turk J Biochem"},{"issue":"69","key":"CIT0021-20250902","doi-asserted-by":"crossref","first-page":"69","DOI":"10.31386\/dmj.2021.15.1.7","article-title":"Oxidative stress in dental caries and periodontal disease among secondary school students in Duhok, Kurdistan Region, Iraq","volume":"15","author":"Hamonari","year":"2021","journal-title":"Duhok Med J"},{"key":"CIT0022-20250902","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2478\/v10039-012-0015-9","article-title":"Dental caries and total antioxidant status of unstimulated mixed whole saliva in patients aged 16\u201323 years","volume":"57","author":"Krawczyk","year":"2012","journal-title":"Adv Med Sci"}],"container-title":["Journal of International Society of Preventive and Community Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jispcd.jispcd_116_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:39:41Z","timestamp":1787067581000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jispcd.jispcd_116_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jispcd.jispcd_116_24","relation":{},"ISSN":["2231-0762","2250-1002"],"issn-type":[{"value":"2231-0762","type":"print"},{"value":"2250-1002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-07-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}