{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:38:42Z","timestamp":1786653522122,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Int Soc Prev Community Dent"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>bstract<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Oral cancer is a leading cause of mortality in India, yet rural populations face severe barriers to its early detection. This study evaluates the efficacy of a novel, portable optical screening device (OncoDiagnoScope) and assesses demographic risk factors in a resource-limited setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This community-based cross-sectional study (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 1358; mean age 51.8 \u00b1 13.7 years) was conducted in rural Tamil Nadu. Participants underwent a multitiered screening protocol: initial assessment via OncoDiagnoScope, secondary clinical evaluation by specialists, and histopathological confirmation for suspicious lesions. Risk factors were analyzed using univariate and multivariate logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The OncoDiagnoScope identified 321 suspects (23.6%), of which 101 (7.4%) were clinically confirmed as having oral lesions and nine cases (0.66%) were histopathologically confirmed as malignancies. The device demonstrated a sensitivity of 100%, specificity of 82.14%, and a negative predictive value (NPV) of 100% compared to expert clinical examination. While univariate analysis showed significant associations between lesions and age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.040), tobacco chewing (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009), and betel leaf use (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), these variables were not independent predictors in the multivariate adjusted model (Pseudo-R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The OncoDiagnoScope is a highly sensitive, non-invasive tool for community-level oral cancer triaging. Despite a low positive predictive value (31.46%), its ability to accurately rule out disease (NPV 100%) makes it an ideal aid for rural outreach. Integrating portable diagnostic technologies into existing health-wellness programs can significantly bridge the gap in early cancer detection for marginalized populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jispcd.jispcd_134_25","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:00:08Z","timestamp":1777525208000},"page":"172-181","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Oral Cancer Screening and Demographic Risk Assessment: A Community-Based Cross-sectional Study in Rural India"],"prefix":"10.4103","volume":"16","author":[{"given":"Koteswararao","family":"Mallaparapu","sequence":"first","affiliation":[{"name":"Department of Electronics and Communication Engineering, School of Engineering and Sciences, SRM University-AP, Amaravati, Andhra Pradesh,India"},{"name":"BioMedical Research and Artificial Intelligence Network (BRAIN) Laboratory, SRM University AP, Amaravati, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Ratna","family":"Bhaskar","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering, School of Engineering and Sciences, SRM University-AP, Amaravati, Andhra Pradesh,India"},{"name":"BioMedical Research and Artificial Intelligence Network (BRAIN) Laboratory, SRM University AP, Amaravati, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Menaka","sequence":"additional","affiliation":[{"name":"Radiation Applications & Metrology Section Radiological Applications and Technology Division, Safety, Quality and Resource Management Group, Indira Gandhi Centre for Atomic Research, KalpakkamTamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Electronics and Instrumentation Engineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamina","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Tamil Nadu,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Logaraj","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Tamil Nadu,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gnana Sarita Kumari","family":"Panga","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry and Department of Clinical Research, SIBAR Institute of Dental Sciences, Takkellapadu, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Sunitha","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering, School of Engineering and Sciences, SRM University-AP, Amaravati, Andhra Pradesh,India"},{"name":"BioMedical Research and Artificial Intelligence Network (BRAIN) Laboratory, SRM University AP, Amaravati, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"CIT0002-20260430","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"CIT0003-20260430","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/odi.14974","article-title":"Oral cancer in India","volume":"31","author":"Ray","year":"2025","journal-title":"Oral 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