{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:18:23Z","timestamp":1788437903746,"version":"build-2803163510"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Int Soc Prev Community Dent"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>\n                    <jats:sc>Abstract<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Preeclampsia (PE) affects 2%\u20138% of pregnancies globally and represents a significant maternal health challenge, characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. Periodontal disease, defined as chronic inflammation affecting tooth-supporting structures, demonstrates a notably high prevalence among pregnant women. The objective of the present study was to compare serum inflammatory markers and periodontal status between preeclamptic and normotensive pregnant women in a cross-sectional design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Sixty pregnant women were recruited\u201430 preeclamptic and 30 normotensive\u2014from the Department of Obstetrics and Gynecology, K.S. Hegde Hospital, Mangalore. Oral health evaluations were performed during hospital admission for delivery or 48\u2009h before planned delivery to assess periodontal status. Following the examination of oral health status, the normotensive and preeclamptic pregnant women were grouped as preeclamptic women with healthy periodontium (PH), preeclamptic women with periodontitis (PP), normotensive women with healthy periodontium (NH), and normotensive women with periodontitis (NP) to compare the serum cytokine levels and periodontal status among the subgroups. Periodontitis was defined as a clinical attachment level \u22653\u2009mm in \u226530% of examined sites, assessed by a single calibrated examiner. Serum levels of interleukin (IL)-10, IL-4, tumor necrosis factor-alpha (TNF-\u03b1), and IL-2 were quantified using enzyme-linked immunosorbent assay. Group comparisons were performed using the Kruskal\u2013Wallis test with\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      Bonferroni correction for cytokine data and one-way analysis of variance for periodontal parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Periodontitis was significantly more prevalent in preeclamptic women (63.3%) compared to normotensive women (30%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.010). Serum IL-10 levels were significantly lower in the PP group (3.36 [3.06, 5.61] pg\/mL) compared to the NH group (7.61 [3.52, 10.03] pg\/mL) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.010,\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      Bonferroni correction). Serum levels of TNF-\u03b1, IL-2, and IL-4 showed no statistically significant differences across subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this cross-sectional study, periodontitis was associated with lower serum IL-10 levels in preeclamptic women, suggesting a possible immune dysregulation between periodontal disease and PE. A causal relationship cannot be established from the present observational data. These findings warrant further investigation through larger prospective longitudinal studies to establish temporality and causation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jispcd.jispcd_197_25","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T08:00:41Z","timestamp":1779868841000},"page":"397-404","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Altered Serum IL-10 Levels in Preeclamptic Women with Periodontitis: A Cross-Sectional Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Mamatha Shekar","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Periodontics, AB Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna Kumar","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchetha N.","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Srinivas University Mukka, Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa S.","family":"Shetty","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Nitte (Deemed to be University), Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neevan","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir Ram","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"CIT0002-20260903","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2022.06.038","article-title":"Preeclampsia: A report and recommendations of the workshop of the Society for Maternal-Fetal Medicine and the Preeclampsia Foundation","volume":"227","author":"Louis","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"CIT0003-20260903","doi-asserted-by":"crossref","first-page":"e30787","DOI":"10.1097\/MD.0000000000030870","article-title":"Cytokine-polymorphisms associated with Preeclampsia: A review","volume":"101","author":"Mora-Palazuelos","year":"2022","journal-title":"Medicine 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Correlation between oral hygiene and periodontal condition","volume":"22","author":"Silness","year":"1964","journal-title":"Acta Odontol Scand"},{"key":"CIT0012-20260903","doi-asserted-by":"crossref","first-page":"3360082","DOI":"10.1155\/ijod\/3360082","article-title":"Evaluation the risk of preeclampsia in periodontal patients compared with healthy individuals: A meta\u2010analysis study","volume":"2025","author":"Ansari Moghaddam","year":"2025","journal-title":"Int J Dentistry"},{"key":"CIT0013-20260903","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/JPER.23-0008","article-title":"Relationship between C\u2010reactive protein level and periodontitis and systemic diseases","volume":"95","author":"Lee","year":"2024","journal-title":"J Periodontol"},{"key":"CIT0014-20260903","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.preghy.2022.10.011","article-title":"Maternal tumour necrosis factor-alpha levels in preeclamptic pregnancies in Lagos, South-West Nigeria","volume":"30","author":"Adenekan","year":"2022","journal-title":"Pregnancy Hypertens"},{"key":"CIT0015-20260903","doi-asserted-by":"crossref","first-page":"862","DOI":"10.3390\/biomedicines11030862","article-title":"Polymorphisms within the tumor necrosis factor-alpha gene is associated with preeclampsia in Taiwanese Han populations","volume":"11","author":"Lin","year":"2023","journal-title":"Biomedicines"},{"key":"CIT0016-20260903","doi-asserted-by":"crossref","first-page":"1168625","DOI":"10.3389\/fmed.2023.1168625","article-title":"The potential role of the gingival crevicular fluid biomarkers in the prediction of pregnancy complications","volume":"10","author":"Abouzaid","year":"2023","journal-title":"Front Med"},{"key":"CIT0017-20260903","doi-asserted-by":"crossref","first-page":"10094","DOI":"10.3390\/ijms262010094","article-title":"Pro-Inflammatory and anti-inflammatory interleukins in periodontitis: Molecular roles, immune crosstalk, and therapeutic perspectives","volume":"26","author":"Mart\u00ednez-Garc\u00eda","year":"2025","journal-title":"Int J Mol Sci"},{"key":"CIT0018-20260903","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1186\/s12903-023-03072-1","article-title":"Pro-and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases: Systematic review and meta-analysis","volume":"23","author":"Oliveira","year":"2023","journal-title":"BMC Oral Health"},{"key":"CIT0019-20260903","first-page":"448","article-title":"Association of periodontal disease with adverse pregnancy outcomes","volume":"15","author":"Dogra","year":"2025","journal-title":"Euro J Cardiovascul Med"},{"key":"CIT0020-20260903","first-page":"95","article-title":"The association between periodontal disease and pregnancy loss: A systematic review and metanalysis","volume":"43","author":"Baher","year":"2025","journal-title":"J Dental School, Shahid Beheshti Univer Med Sci"}],"container-title":["Journal of International Society of Preventive and Community Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jispcd.jispcd_197_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:01:27Z","timestamp":1788436887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jispcd.jispcd_197_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jispcd.jispcd_197_25","relation":{},"ISSN":["2231-0762","2250-1002"],"issn-type":[{"value":"2231-0762","type":"print"},{"value":"2250-1002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"2025-11-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}