{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:24:14Z","timestamp":1790691854677,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Int Soc Prev Community Dent"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>\n                    <jats:sc>Abstract<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The association between periodontal disease and atherosclerosis has gained significant attention, yet the intellectual structure and most influential works in this interdisciplinary field have not been systematically mapped. This study aimed to identify and analyze the characteristics, collaborative networks, and evolving research trends of the 100 most-cited articles concerning the relationship between periodontal disease and atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A comprehensive search was performed in the Web of Science Core Collection on January 24, 2025. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace, and the \u201cbibliometrix\u201d R package. Metrics included total citations, h-index, and keyword burst detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The 100 articles garnered a total of 13,968 citations (average: 195.6 citations per article). The United States was the leading contributor (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 40), with the University of North Carolina identified as the most productive institution. The\n                      <jats:italic toggle=\"yes\">Journal of Periodontology<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Circulation<\/jats:italic>\n                      were the primary publication venues. Keyword clustering identified six research hotspots: risk factors, inflammatory responses, infection, confounding variables,\n                      <jats:italic toggle=\"yes\">Porphyromonas gingivalis<\/jats:italic>\n                      , and related cardiovascular conditions. Burst analysis revealed a paradigm shift in research focus from mechanistic \u201cinfection\u201d (2004\u20132005) to clinical \u201ctherapy\u201d (2013\u20132020).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study delineates the foundational literature and thematic evolution of the periodontal\u2013atherosclerosis link. The observed shift in the literature from mechanistic to interventional studies may correlate with an increase in publications on periodontal treatment for cardiovascular prevention. These findings provide a data-driven roadmap for future longitudinal trials and clinical guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jispcd.jispcd_214_25","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:01:11Z","timestamp":1787832071000},"page":"423-434","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The 100 Most-Cited Articles on Periodontal Disease and Atherosclerosis: A Bibliometric Study (1989\u20132025)"],"prefix":"10.4103","volume":"16","author":[{"given":"Liang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endodontics, Jinan Stomatological Hospital Shungeng Branch, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Stomatology, Shandong Medical and Pharmaceutical University, Yantai, Shandong, China"},{"name":"Department of Endodontics, Jinan Stomatological Hospital, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Jinan Stomatological Hospital, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jinan Stomatological Hospital East Branch, Jinan Stomatological Hospital, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The People\u2019s Hospital of Gaoqing District, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Du","sequence":"additional","affiliation":[{"name":"Central Laboratory, Jinan Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration, Jinan Key Laboratory of Oral Diseases and Tissue Regeneration, Shandong Provincial Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration, Jinan Stomatological Hospital, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Central Laboratory, Jinan Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration, Jinan Key Laboratory of Oral Diseases and Tissue Regeneration, Shandong Provincial Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration, Jinan Stomatological Hospital, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"CIT0001-20260903","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/prd.12430","article-title":"Interconnection of periodontal disease and comorbidities: Evidence, 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