{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:19Z","timestamp":1787071339805,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Int Soc Prev Community Dent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>bstract<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Secretory immunoglobulin-A (sIgA) plays a crucial role in the immune response and in protecting the oral mucosa as part of the body\u2019s defense system. Periodontitis, caries, fungal infections, and halitosis are among the most common oral illnesses treated with probiotics today. The study analyzes the outcome of multi-strain probiotics on the levels of sIgA in completely edentulous patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 52 participants who were fully edentulous and wearing removable complete denture prosthesis were recruited for the research. The subjects were split into two groups. Patients in Group I (experimental) were given the multi-strain probiotic Lee-Biotic (Leeford Healthcare Ltd.), whereas those in Group II (control) did not receive any probiotic prescriptions. The enzyme-linked immunosorbent assay (ELISA) was employed to assess sIgA levels at baseline, 2 months later, and 3 months later. The collected data were statistically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean baseline sIgA levels were 1.032\u2009mg\/mL in the probiotic group and 0.432\u2009mg\/mL in the non-probiotic group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). After 3 months, the probiotic group exhibited a significant increase to 2.254\u2009mg\/mL, whereas the non-probiotic group reached 1.213\u2009mg\/mL. The probiotic group showed a statistically significant increase (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) in sIgA levels over the 3-month period, indicating a strong immunological response. In contrast, the non-probiotic group showed a modest increase, suggesting that the non-probiotic supplement has a limited effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Commercially available multi-strain probiotic supplements increased the levels of sIgA in edentulous patients who were old denture wearers. Multi-strain probiotics have been shown to increase sIgA levels. This enhancement may contribute to improved oral immunity and reduced susceptibility to oral infections in the denture wearer population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jispcd.jispcd_36_25","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:00:14Z","timestamp":1757584814000},"page":"435-441","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a Multi-Strain Probiotic on Secretory Immunoglobulin-A Levels in Patients with Complete Edentulism: A Quasi-Experimental Study"],"prefix":"10.4103","volume":"15","author":[{"given":"Harsimran","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Dental Surgery, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Manav Rachna Dental College, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakila","family":"Mahesh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Manav Rachna Dental College, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navdha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Manav Rachna Dental College, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"CIT0001-20251030","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.3889\/oamjms.2018.419","article-title":"Effect of denture base reinforcement using light cured E- glass 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