{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:31:35Z","timestamp":1786728695213,"version":"build-2736575974"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JISPCD"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>bstract<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims and Objectives:<\/jats:title>\n                    <jats:p>The primary objectives of this study were to compare salivary oxidative stress (OS) biomarker levels in patients with type 1 diabetes mellitus (T1DM) and without T1DM (non-T1DM) and evaluate the relationships between diabetes, periodontal status, and OS biomarker levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Twenty patients with T1DM and 20 age-matched patients without T1DM were enrolled. All participants were 15\u201323 years of age and had permanent dentition. Unstimulated whole saliva was collected in a sterile test tube before examination of clinical periodontal parameters, including bleeding on probing (BOP). Salivary levels of OS biomarkers\u2014malondialdehyde, protein carbonyl, total oxidant status (TOS), and total antioxidant capacity\u2014were determined using oxidative and antioxidative assays followed by spectrophotometric measurement at 375\u2013532\u2009nm. The relationships between diabetes, periodontal status, and OS biomarkers were analyzed using multiple linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      TOS was significantly lower in the T1DM group compared with the non-T1DM group (5.06\u2009\u00b1\u20090.39 vs. 6.44\u2009\u00b1\u20090.51 \u00b5mol H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      Eq\/l,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.035). After adjusting for confounding factors (age, gender, BMI, clinical periodontal parameters, BOP, or diabetes status accordingly), the multiple linear regression showed that T1DM was significantly associated with a reduction of TOS level (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.008). The BOP &gt; 30% group showed a significant correlation with increased TOS levels compared with the BOP \u2264 30% group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002). No relationship was found between OS biomarkers and HbA1c levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Salivary TOS levels were related to both diabetes status and the extent of gingival inflammation. Further studies to elucidate the role of OS in relation of periodontal disease and T1DM are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jispcd.jispcd_38_23","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T05:01:18Z","timestamp":1693458078000},"page":"333-341","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Salivary oxidative stress biomarkers in thai adolescents and young adults with type 1 diabetes mellitus: A cross-sectional study"],"prefix":"10.4103","volume":"13","author":[{"given":"Thanwarat","family":"Aroonrangsee","sequence":"first","affiliation":[{"name":"Residency Training Programs in Periodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachanin","family":"Chairatnathrongporn","sequence":"additional","affiliation":[{"name":"Residency Training Programs in Periodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand"},{"name":"Private Practice, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudee","family":"Surarit","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kallapat","family":"Tansriratanawong","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeerunda","family":"Santiprabhob","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"},{"name":"Siriraj Diabetes Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chatkoew","family":"Boriboonhirunsarn","sequence":"additional","affiliation":[{"name":"Dental Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Promsudthi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"CIT0001-20240828","first-page":"S10","article-title":"Thailand diabetes registry project: Type of diabetes, glycemic control and prevalence of microvascular complications in children and adolescents with diabetes","volume":"89","author":"Likitmaskul","year":"2006","journal-title":"J Med Assoc 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