{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:18:33Z","timestamp":1788437913618,"version":"build-2803163510"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Int Soc Prev Community Dent"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>\n                    <jats:sc>Abstract<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The study aimed to determine the distribution of congenital heart diseases (CHDs), associated congenital malformations, and syndromes among children with orofacial clefts (OFCs) at Tawanchai Cleft Center, Khon Kaen, Thailand from 2011 to 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The retrospective study reviewed medical records of 1187 children with OFCs at a tertiary cleft center from 2011 to 2020. A total of 95 eligible cases met the following inclusion criteria: diagnosis of cleft palate (CP), cleft lip (CL), or cleft lip and palate (CLP); age from birth to 3 years; confirmed CHD diagnosis by a cardiologist; confirmed diagnosis of congenital malformations or syndromes by a geneticist; and complete medical records. Distributions were described using frequencies and percentages. Fisher\u2019s exact test and binary logistic regression (unadjusted and sex-adjusted) were used for inferential analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 95 patients, CP was the most frequent OFC type (48.4%), followed by CLP (44.2%) and CL (7.4%). The sex distribution was 48.4% male and 51.6% female, and all patients were of Thai ethnicity. The observed proportion of CHDs (8.0%) fell in the mid-range of prior studies. The most common CHDs were atrial septal defect (ASD, 25.3%), patent ductus arteriosus (PDA, 20.0%), and ventricular septal defect (VSD, 18.9%). Pierre Robin sequence (PRS) was the most common associated congenital malformation (10.4%). Syndromic clefts occurred in 38 cases (40.0%), predominantly involving 22q11.2 deletion syndrome (18.4%), vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, and limb abnormalities association (13.1%), and Down syndrome (7.9%). Binary logistic regression revealed significantly lower odds of VSD in patients with unilateral CLP compared to those with CL (sex-adjusted odds ratio = 0.07, 95% confidence interval = 0.01\u20130.61,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ASD, PDA, and VSD are the most common CHDs among patients with OFCs. These CHDs frequently co-occur with PRS and 22q11.2 deletion syndrome. These findings underscore the importance of comprehensive cardiac screening in children with OFCs to support interdisciplinary cleft care management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jispcd.jispcd_52_26","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:01:09Z","timestamp":1787832069000},"page":"364-377","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Congenital Heart Diseases, Associated Malformations, and Syndromes in Thai Children with Orofacial Clefts: A 10-Year Retrospective Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Krispijyakorn","family":"Sangharn","sequence":"first","affiliation":[{"name":"Division of Orthodontics, Department of Preventive Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonsak","family":"Pisek","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, Department of Preventive Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand"},{"name":"International College of Dentistry, Walailak University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araya","family":"Pisek","sequence":"additional","affiliation":[{"name":"Division of Dental Public Health, Department of Preventive Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buddhathida","family":"Wangsrimongkol","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, Department of Preventive Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waranuch","family":"Pitiphat","sequence":"additional","affiliation":[{"name":"Division of Dental Public Health, Department of Preventive Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Bloch-Zupan","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 de Strasbourg, Strasbourg, France"},{"name":"H\u00f4pitaux Universitaires de Strasbourg (HUS), P\u00f4le de M\u00e9decine et Chirurgie Bucco-Dentaires, Centre de R\u00e9f\u00e9rence des Maladies Rares Orales et Dentaires, CRMR-O-Rares, Fili\u00e8re Sant\u00e9 Maladies Rares TETE COU and European Reference Network ERN CRANIO, Strasbourg, France"},{"name":"CNRS-UMR7104, INSERM U1258 Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), Universit\u00e9 de Strasbourg, Illkirch, France"},{"name":"Institut d\u2019Etudes Avanc\u00e9es (USIAS), Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supawich","family":"Morkmued","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry, Department of Preventive Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khunton","family":"Wichajarn","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"CIT0001-20260903","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12887-017-0833-9","article-title":"Congenital malformations and medical conditions associated with orofacial clefts in children 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