{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:30:06Z","timestamp":1787772606482,"version":"build-2784847793"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.4103\/jispcd.jispcd_56_21","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T03:52:20Z","timestamp":1691812340000},"page":"348-356","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of Complex Phytoadaptogens as an Adjunct to Non-surgical Treatment of Chronic Periodontitis"],"prefix":"10.4103","volume":"11","author":[{"given":"Zhanna Valerevna","family":"Dzampaeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Sergeevna","family":"Datieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaira Savelevna","family":"Esenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Astanovna","family":"Takoeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20240828","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3389\/fcimb.2019.00432","article-title":"The role of Treponema denticola motility in synergistic biofilm formation with Porphyromonas gingivalis","volume":"9","author":"Ng","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"R2-15-20240828","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12200","article-title":"Periodontitis epidemiology: Is periodontitis under-recognized, over-diagnosed, or both?","volume":"75","author":"Papapanou","year":"2017","journal-title":"Periodontol 2000"},{"key":"R3-15-20240828","doi-asserted-by":"crossref","first-page":"5491923","DOI":"10.1155\/2017\/5491923","article-title":"Periodontal status and quality of life: Impact of fear of pain and dental fear","volume":"2017","author":"Wright","year":"2017","journal-title":"Pain Res Manag"},{"key":"R4-15-20240828","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/prd.12234","article-title":"Contemporary approaches for identifying individual risk for periodontitis","volume":"78","author":"Kornman","year":"2018","journal-title":"Periodontol 2000"},{"key":"R5-15-20240828","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/prd.12258","article-title":"Focal infection of periodontal origin","volume":"79","author":"Slots","year":"2019","journal-title":"Periodontol 2000"},{"key":"R6-15-20240828","first-page":"1097","article-title":"Architecture and amount of alveolar bone loss in patients with chronic periodontitis modified by diabetes mellitus type 2: A retrospective study","volume":"13","author":"Al-Bayaty","year":"2020","journal-title":"J Int Dent Med Res"},{"key":"R7-15-20240828","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1590\/1678-775720140259","article-title":"Host response mechanisms in periodontal diseases","volume":"23","author":"Silva","year":"2015","journal-title":"J Appl Oral Sci"},{"key":"R8-15-20240828","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/jcpe.13056","article-title":"Osteoimmunology: Inflammatory osteolysis and regeneration of the alveolar bone","volume":"46","author":"Gruber","year":"2019","journal-title":"J Clin Periodontol"},{"key":"R9-15-20240828","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: Dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"R10-15-20240828","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"Meyle","year":"2015","journal-title":"Periodontol 2000"},{"key":"R11-15-20240828","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/idh.12399","article-title":"Success of non-surgical periodontal therapy in adult periodontitis patients: A retrospective analysis","volume":"17","author":"Van der Weijden","year":"2019","journal-title":"Int J Dent Hyg"},{"key":"R12-15-20240828","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/JPER.19-0023","article-title":"Professional tooth cleaning prior to non-surgical periodontal therapy: A randomized clinical trial","volume":"91","author":"Jentsch","year":"2020","journal-title":"J Periodontol"},{"key":"R13-15-20240828","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.4049\/jimmunol.1900046","article-title":"Systemic antibiotic therapy reduces circulating inflammatory dendritic cells and Treg-Th17 plasticity in periodontitis","volume":"202","author":"Rajendran","year":"2019","journal-title":"J Immunol"},{"key":"R14-15-20240828","first-page":"978","article-title":"Medicinal plants for gingivitis: A review of clinical trials","volume":"21","author":"Safiaghdam","year":"2018","journal-title":"Iran J Basic Med Sci"},{"key":"R15-15-20240828","doi-asserted-by":"crossref","first-page":"152881","DOI":"10.1016\/j.phymed.2019.152881","article-title":"Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells","volume":"60","author":"Panossian","year":"2019","journal-title":"Phytomedicine"},{"key":"R16-15-20240828","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.phymed.2018.09.204","article-title":"Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology","volume":"50","author":"Panossian","year":"2018","journal-title":"Phytomedicine"},{"key":"R17-15-20240828","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/med.21743","article-title":"Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases","volume":"41","author":"Panossian","year":"2021","journal-title":"Med Res Rev"},{"key":"R18-15-20240828","first-page":"103","article-title":"[Ethanol extract of Rhodiola rosea L. regulates the number of tumor infiltrating T cells to enhance antitumor effect in lewis lung cancer-bearing mice]","volume":"35","author":"Zhang","year":"2019","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"R19-15-20240828","doi-asserted-by":"crossref","first-page":"262","DOI":"10.14300\/mnnc.2020.15062","article-title":"Assessment of the efficiency of the application of complex phytoadaptogens in the treatment of inflammatory diseases of periodontal","volume":"15","author":"Dzampaeva","year":"2020","journal-title":"Med News North Caucasus"},{"key":"R20-15-20240828","first-page":"4956","article-title":"Multi-pathway integrated adjustment mechanism of licorice flavonoids presenting anti-inflammatory activity","volume":"18","author":"Yu","year":"2019","journal-title":"Oncol Lett"},{"key":"R21-15-20240828","doi-asserted-by":"crossref","first-page":"e186","DOI":"10.3390\/antiox8060186","article-title":"Antioxidant and anti-inflammatory activities of flavanones from Glycyrrhizaglabra L. (licorice) leaf phytocomplexes: Identification of licoflavanone as a modulator of NF-kB\/MAPK pathway","volume":"6","author":"Frattaruolo","year":"2019","journal-title":"Antioxidants (Basel"},{"key":"R22-15-20240828","doi-asserted-by":"crossref","first-page":"105870","DOI":"10.1016\/j.intimp.2019.105870","article-title":"Glycyrrhetinic acid pretreatment attenuates liver ischemia\/reperfusion injury via inhibiting TLR4 signaling cascade in mice","volume":"76","author":"Jiang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"R23-15-20240828","first-page":"43","article-title":"Antioxidant, cytotoxic, and antimicrobial activities of Glycyrrhiza glabra L., Paeonia lactiflora Pall., and Eriobotrya japonica (Thunb.) Lindl","volume":"2","author":"Zhou","year":"2019","journal-title":"Extracts Med"},{"key":"R24-15-20240828","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jclinane.2018.10.025","article-title":"Topical application of licorice for prevention of postoperative sore throat in adults: A systematic review and meta-analysis","volume":"54","author":"Kuriyama","year":"2019","journal-title":"J Clin Anesth"},{"key":"R25-15-20240828","first-page":"9","article-title":"Participation of pineal gland in antistressor activity of adaptogenic drugs","volume":"1","author":"Arushanian","year":"2015","journal-title":"EkspKlin Farmakol"},{"key":"R26-15-20240828","doi-asserted-by":"crossref","first-page":"6910312","DOI":"10.1155\/2020\/6910312","article-title":"RANKL\/RANK\/OPG pathway: A mechanism involved in exercise-induced bone remodeling","volume":"2020","author":"Tobeiha","year":"2020","journal-title":"Biomed Res Int"},{"key":"R27-15-20240828","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s00223-018-0425-1","article-title":"Glycyrrhizin suppresses RANKL-induced osteoclastogenesis and oxidative stress through inhibiting NF-\u03bab and MAPK and activating AMPK\/nrf2","volume":"103","author":"Li","year":"2018","journal-title":"Calcif Tissue Int"},{"key":"R28-15-20240828","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.mvr.2018.10.010","article-title":"Age-related changes in gingival blood flow parameters measured using laser speckle flowmetry","volume":"122","author":"Ohsugi","year":"2019","journal-title":"Microvasc Res"},{"key":"R29-15-20240828","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s00784-020-03427-w","article-title":"Microcirculation and somatosensory profiling of patients with periodontitis: A preliminary case control report","volume":"25","author":"Fan","year":"2020","journal-title":"Clin Oral Investig"},{"key":"R30-15-20240828","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.11607\/prd.2079","article-title":"Association of salivary lipid peroxidation levels, antioxidant enzymes, and chronic periodontitis","volume":"35","author":"Trivedi","year":"2015","journal-title":"Int J Periodont Restorat Dent"},{"key":"R31-15-20240828","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jshs.2016.05.005","article-title":"Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men","volume":"7","author":"J\u00f3wko","year":"2018","journal-title":"J Sport Health Sci"},{"key":"R32-15-20240828","doi-asserted-by":"crossref","first-page":"153143","DOI":"10.1016\/j.phymed.2019.153143","article-title":"Rhodiola rosea L. modulates inflammatory processes in a CRH-activated BV2 cell model","volume":"68","author":"Borgonetti","year":"2020","journal-title":"Phytomedicine"},{"key":"R33-15-20240828","doi-asserted-by":"crossref","first-page":"109552","DOI":"10.1016\/j.biopha.2019.109552","article-title":"Anti-inflammatory effects of Rhodiola rosea L.: A review","volume":"121","author":"Pu","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"R34-15-20240828","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.5005\/jp-journals-10024-2724","article-title":"In vitro analysis of licorice (Glycyrrhiza glabra) root extract activity on Streptococcus mutans in comparison to chlorhexidine and fluoride mouthwash","volume":"20","author":"Malvania","year":"2019","journal-title":"J Contemp Dent Pract"},{"key":"R35-15-20240828","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1111\/jcpe.12682","article-title":"Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of Group 1 of the Joint EFP\/ORCA Workshop on the Boundaries between caries and periodontal disease","volume":"44","author":"Sanz","year":"2017","journal-title":"J Clin Periodontol"},{"key":"R36-15-20240828","doi-asserted-by":"crossref","first-page":"358","DOI":"10.5177\/ntvt.2020.06.20032","article-title":"[Stress and periodontitis]","volume":"127","author":"Pitzurra","year":"2020","journal-title":"Ned Tijdschr Tandheelkd"},{"key":"R37-15-20240828","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1055\/s-0039-1693507","article-title":"Association between psychological stress and periodontitis: A systematic review","volume":"14","author":"Castro","year":"2020","journal-title":"Eur J Dent"},{"key":"R38-15-20240828","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00784-019-03089-3","article-title":"The assessment of stress, depression, and inflammation as a collective risk factor for periodontal diseases: A systematic review","volume":"24","author":"Decker","year":"2020","journal-title":"Clin Oral Investig"},{"key":"R39-15-20240828","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1007\/s00784-019-03083-9","article-title":"Is there association between stress and periodontitis?","volume":"24","author":"Coelho","year":"2020","journal-title":"Clin Oral Investig"},{"key":"R40-15-20240828","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1002\/fsn3.1249","article-title":"Reduction of acute mild stress corticosterone response and changes in stress-responsive gene expression in male balb\/c mice after repeated administration of a Rhodiola rosea L. root extract","volume":"7","author":"Dinel","year":"2019","journal-title":"Food Sci Nutr"},{"key":"R41-15-20240828","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase","volume":"303","author":"Brunet","year":"2004","journal-title":"Science"},{"key":"R42-15-20240828","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/sj.cdd.4401837","article-title":"Roles for NF-kappab in nerve cell survival, plasticity, and disease","volume":"13","author":"Mattson","year":"2006","journal-title":"Cell Death Differ"},{"key":"R43-15-20240828","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10517-015-3040-4","article-title":"Effects of phytoadaptogen on hepatoma development in cancer-prone CBA mice","volume":"159","author":"Bocharova","year":"2015","journal-title":"Bull Exp Biol Med"},{"key":"R44-15-20240828","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12903-019-0720-x","article-title":"Chronodentistry: The role and potential of molecular clocks in oral medicine","volume":"19","author":"Janji\u0107","year":"2019","journal-title":"BMC Oral Health"},{"key":"R45-15-20240828","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ncl.2019.04.003","article-title":"Circadian rhythm sleep-wake phase disorders","volume":"37","author":"Culnan","year":"2019","journal-title":"Neurol Clin"},{"key":"R46-15-20240828","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.molmed.2016.03.004","article-title":"Dosing-time makes the poison: Circadian regulation and pharmacotherapy","volume":"22","author":"Dallmann","year":"2016","journal-title":"Trends Mol Med"},{"key":"R47-15-20240828","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbrc.2012.02.076","article-title":"Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver","volume":"419","author":"Sato","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"R49-15-20240828","doi-asserted-by":"crossref","first-page":"153181","DOI":"10.1016\/j.phymed.2020.153181","article-title":"A comparative study on root and bark extracts of Eleutherococcus senticosus and their effects on human macrophages","volume":"68","author":"Jin","year":"2020","journal-title":"Phytomedicine"},{"key":"R50-15-20240828","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1538\/expanim.62.247","article-title":"Immunostimulating effects of extract of Acanthopanax sessiliflorus","volume":"62","author":"Kim","year":"2013","journal-title":"Exp Anim"}],"container-title":["Journal of International Society of Preventive and Community Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jispcd.JISPCD_56_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:05:46Z","timestamp":1787771146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jispcd.JISPCD_56_21"}},"subtitle":["A Randomized Clinical Trial"],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jispcd.jispcd_56_21","relation":{},"ISSN":["2231-0762"],"issn-type":[{"value":"2231-0762","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}