{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:26:30Z","timestamp":1790922390085,"version":"4.1.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Int Soc Prev Community Dent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>bstract<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Vital pulp therapy is increasingly used in managing mature permanent teeth exposed to caries. Biodentine, a tricalcium silicate-based material, has emerged as a potential alternative to mineral trioxide aggregate (MTA) in pulpotomy procedures due to its favorable properties of handling and biocompatibility. The aim was to systematically evaluate and compare the clinical and radiographic outcomes of biodentine and MTA as pulpotomy agents in mature permanent teeth exposed to caries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis was registered with International Prospective Register of Systematic Reviews (CRD4202457708) and followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. A comprehensive search of MEDLINE, Scopus, EBSCOhost, OpenGrey, and relevant journals was conducted up to August 31, 2024, to identify randomized controlled trials (RCTs). Studies comparing biodentine and MTA in mature permanent teeth with carious pulp exposure were included. The risk of bias was assessed using the Joanna Briggs Institute checklist, and statistical analysis was conducted using RevMan 5.4. The certainty of evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Seven RCTs were included in the systematic review, of which three were eligible for meta-analysis. The pooled results showed no significant difference between biodentine and MTA regarding clinical and radiographic success (odds ratio = 0.77; 95% confidence interval: 0.24\u20132.49;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.66). Heterogeneity was low (\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0%), and no significant publication bias was detected. However, the GRADE assessment rated the certainty of evidence as low due to imprecision and potential risk of bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both biodentine and MTA demonstrate comparable clinical and radiographic success as pulpotomy agents in mature permanent teeth exposed to caries pulp. Given its advantageous handling and lower discoloration potential, biodentine may serve as a suitable alternative to MTA. Further high-quality trials are warranted to strengthen the current evidence base.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jispcd.jispcd_71_25","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T13:00:09Z","timestamp":1755954009000},"page":"313-322","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and Radiographic Outcomes Following Pulpotomy Using Biodentine in Carious Exposed Mature Permanent Teeth: A Systematic Review and Meta-analysis"],"prefix":"10.4103","volume":"15","author":[{"given":"Unnati","family":"Soma","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, SDS, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, SDS, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, SDS, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dax","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, SDS, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, SDS, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Neha","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, SDS, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"CIT0001-20250902","first-page":"46","article-title":"Vital pulp therapy an insight over the available literature and future expectations","volume":"5","author":"Hanna","year":"2020","journal-title":"Eur Endod 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Endod"},{"key":"CIT0005-20250902","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/iej.12841","article-title":"Mineral trioxide aggregate and other bioactive endodontic cements: An updated overview - part I: Vital pulp therapy","volume":"51","author":"Parirokh","year":"2018","journal-title":"Int Endod J"},{"key":"CIT0006-20250902","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/iej.13707","article-title":"Outcome of full pulpotomy in mature permanent molars using 3 calcium silicate-based materials: A parallel, double blind, randomized controlled trial","volume":"55","author":"Taha","year":"2022","journal-title":"Int Endod J"},{"key":"CIT0009-20250902","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.joen.2018.08.004","article-title":"Outcomes of vital pulp therapy using mineral trioxide aggregate or biodentine: A prospective randomized clinical trial","volume":"44","author":"Awawdeh","year":"2018","journal-title":"J Endod"},{"key":"CIT0010-20250902","first-page":"317","article-title":"Outcome of partial pulpotomy verses full pulpotomy using biodentine in vital mature permanent molar with clinical symptoms indicative of irreversible pulpitis: A randomized clinical trial","volume":"25","author":"Baranwal","year":"2022","journal-title":"J Conserv Dent"},{"key":"CIT0011-20250902","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.joen.2023.04.001","article-title":"A randomized controlled clinical trial of pulpotomy versus root canal therapy in mature teeth with irreversible pulpitis: outcome, quality of life, and patients\u2019 satisfaction","volume":"49","author":"Taha","year":"2023","journal-title":"J Endod"},{"key":"CIT0012-20250902","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1007\/s00784-023-05136-6","article-title":"Comparative evaluation of treatment outcome of partial pulpotomy using different agents in permanent teeth-a randomized controlled 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review","volume":"37","author":"Aguilar","year":"2011","journal-title":"J Endod"},{"key":"CIT0025-20250902","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/cre2.767","article-title":"Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A systematic review and meta-analysis","volume":"9","author":"Fasoulas","year":"2023","journal-title":"Clin Exp Dent Res"},{"key":"CIT0026-20250902","first-page":"CD003220","article-title":"Pulp treatment for extensive decay in primary teeth","volume":"5","author":"Sma\u00efl-Faugeron","year":"2018","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Journal of International Society of Preventive and Community 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