{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:24:36Z","timestamp":1787840676675,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Int Soc Prev Community Dent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n A\n bstract<\/jats:sc>\n <\/jats:title>\n \n Aim:<\/jats:title>\n To investigate the antimicrobial efficacy of an aloe vera (ALOE)-based mouthwash against key cariogenic pathogens in adults with dental caries, comparing its effects to a standard chlorhexidine (CHX) mouthwash.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n In this single-blind, randomized clinical trial, 54 adults with active dental caries (decayed, missing, and filled teeth [DMFT] \u22653) were assigned to either an ALOE (\n n<\/jats:italic>\n = 27) or a 0.12% CHX (\n n<\/jats:italic>\n = 27) mouthwash group for a 7-day regimen. Unstimulated saliva was collected at baseline and post-intervention. Salivary levels of\n Streptococcus mutans<\/jats:italic>\n ,\n Candida<\/jats:italic>\n , and\n Lactobacilli<\/jats:italic>\n were semi-quantitatively assessed using a modified dip-slide test. Statistical analyses, including the Wilcoxon signed-rank and Mann\u2013Whitney\n U<\/jats:italic>\n -tests, were performed with significance set at\n P<\/jats:italic>\n < 0.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Post-intervention, the ALOE group demonstrated a significant reduction in salivary\n Candida<\/jats:italic>\n levels (\n P<\/jats:italic>\n = 0.008). While a decrease in\n S. mutans<\/jats:italic>\n was observed, it was not statistically significant (\n P<\/jats:italic>\n = 0.096). The CHX group showed significant reductions in both\n S. mutans<\/jats:italic>\n (\n P<\/jats:italic>\n = 0.046) and\n Candida<\/jats:italic>\n (\n P<\/jats:italic>\n = 0.002). Neither group exhibited a significant change in\n Lactobacilli<\/jats:italic>\n levels, nor significant differences in microbial counts were found between the two groups after the 7-day period.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n ALOE mouthwash demonstrates significant antifungal activity against salivary\n Candida<\/jats:italic>\n in adults with dental caries, positioning it as a potential natural alternative for managing oral fungal loads. While its effect on\n S. mutans<\/jats:italic>\n was not as pronounced as CHX in this short-term trial, its efficacy against\n Candida<\/jats:italic>\n warrants further investigation into its long-term benefits for oral health maintenance.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jispcd.jispcd_77_25","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T06:01:53Z","timestamp":1753855313000},"page":"340-347","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Effects of Aloe Vera Mouthwash in Adults with Dental Caries: A Preliminary Clinical Trial"],"prefix":"10.4103","volume":"15","author":[{"given":"Aurasri","family":"Komchornrit","sequence":"first","affiliation":[{"name":"Department of General Dentistry, Faculty of Dentistry, Srinakharinwirot University, Wattana, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patteera","family":"Sodata","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, Pathum Thani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyada","family":"Theerautthavate","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Faculty of Dentistry, Srinakharinwirot University, Wattana, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suteera","family":"Techatanawat","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Faculty of Dentistry, Srinakharinwirot University, Wattana, Bangkok, 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