{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:18:57Z","timestamp":1787750337648,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitamin D is essential for bone and tooth mineralization, and its deficiency may contribute to delayed tooth eruption (DTE) in children. Evidence on this association remains limited and inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To systematically review and analyze the relationship between Vitamin D deficiency and delayed eruption of primary and permanent teeth in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A systematic search of major databases was conducted up to May 2025 following meta-analysis of observational studies in epidemiology guidelines. Observational studies assessing serum Vitamin D in relation to DTE were included. Study quality was evaluated using the Newcastle\u2013Ottawa Scale, and meta-analysis was performed using Review Manager 5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Five studies met the criteria for qualitative review and three for meta-analysis. Although all studies measured Vitamin D in ng\/mL and commonly defined deficiency as &lt;20 ng\/mL, considerable methodological heterogeneity was observed. Meta-analysis for primary dentition showed no significant association (mean difference [MD] = \u221211.90; confidence interval [CI]: \u221230.77\u20136.97;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 95%). Combined analysis of primary and permanent dentition demonstrated a significant difference (MD = \u221216.46; CI: \u221223.86 to \u22129.05;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 91%). Sensitivity analysis improved consistency (MD = \u221221.89; CI: \u221223.78 to \u221220.00;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0%). Calcium levels showed no significant association with DTE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings suggest a possible association between low Vitamin D levels and DTE; however, high heterogeneity and limited evidence reduce certainty. Further well-designed studies are needed to confirm this relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_118_26","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:00:14Z","timestamp":1782745214000},"page":"245-251","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D deficiency as a risk factor for delayed tooth eruption in children \u2013 A systematic review and meta-analysis"],"prefix":"10.4103","volume":"44","author":[{"given":"Unnati","family":"Mathurvaishya","sequence":"first","affiliation":[{"name":"Department Pediatric and Preventive Dentistry, Dr G.D. Pol Foundation YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. N.","family":"Subhadra","sequence":"additional","affiliation":[{"name":"Department Pediatric and Preventive Dentistry, Dr G.D. Pol Foundation YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar N","family":"Katre","sequence":"additional","affiliation":[{"name":"Department Pediatric and Preventive Dentistry, Dr G.D. 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