{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:13Z","timestamp":1787070913759,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Thalassemia is a genetic blood disorder caused by gene mutation leading to chronic anemia, and patients will need routine blood transfusions as a lifetime supportive therapy. Previous studies show high prevalence of periodontal disease in patients who receive routine blood transfusions. Recent studies found probiotic supplementation as an adjuvant therapy in managing periodontal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      This study aimed to analyze the effect of\n                      <jats:italic toggle=\"yes\">Lactobacillus reuteri<\/jats:italic>\n                      probiotic consumption on gingival index and salivary interleukin-1\u03b2 levels of children with thalassemia experiencing gingivitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>This was an evaluative study conducted at a tertiary care hospital in Jakarta, Indonesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants and Methods:<\/jats:title>\n                    <jats:p>\n                      In this study, 16 children aged 6\u201312 with thalassemia major were recruited in Instalasi Pelayanan Terpadu Kesehatan Ibu dan Anak RSUPN Dr. Cipto Mangunkusumo. Dental health education and Lactobacillus\n                      <jats:italic toggle=\"yes\">L<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">reuteri<\/jats:italic>\n                      probiotics supplementation 1\u00d7\/day for 14 days were given to all participants. The gingival index by Lobene was measured at baseline and day 14. Salivary interleukin-1\u03b2 levels were tested by ELISA Kit in a laboratory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>\n                      Dependent\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was a significant difference in gingival index and salivary interleukin-1\u03b2 levels of children with thalassemia after consuming\n                      <jats:italic toggle=\"yes\">L<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">reuteri<\/jats:italic>\n                      probiotics for 14 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">L. reuteri<\/jats:italic>\n                      probiotic consumption for 14 days significantly reduced the gingival index and salivary interleukin-1\u03b2 levels of children with thalassemia experiencing gingivitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_146_25","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T09:00:35Z","timestamp":1751274035000},"page":"231-235","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Lactobacillus reuteri probiotic on gingival index and Interleukin-1\u03b2 levels of children with thalassemia experiencing gingivitis"],"prefix":"10.4103","volume":"43","author":[{"given":"Indira 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