{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:47:52Z","timestamp":1787071672822,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dental caries is a global public health concern, with interproximal caries presenting a particular challenge due to their limited accessibility. Fluoride has long been employed in the prevention and management of early-stage carious lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To evaluate and compare the effectiveness of 38% silver diamine fluoride (SDF) and 5% sodium fluoride varnish (NaF) in arresting interproximal caries in primary molars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>A split-mouth randomized clinical trial was conducted following the CONSORT guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Children aged 5\u20139 years with at least two noncavitated interproximal carious lesions (ICCMS stages RA1\u2013RB4) were included. Teeth were randomly assigned to receive either 38% SDF (Group 1) or 5% NaF varnish (Group 2), applied biannually. Caries arrest was assessed radiographically as primary outcome at 6, 9, and 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>\n                      Descriptive statistics summarized the data. Normality was confirmed through the Shapiro\u2013Wilk test, permitting parametric analysis. Paired and unpaired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests assessed intra- and inter-group differences, respectively, and Chi-square tests analyzed the categorical variables. A two-tailed \u03b1 =0.05 and power of 80% were applied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At the 12-month follow-up, the caries arrest rate was 76.31% in Group 1 and 47.3% in Group 2, showing a statistically significant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The arrest rates for 38% SDF at RA1, RA2, RA3, and RB4 were 90.9%, 88%, 80%, and 37.5%, respectively, compared to 80%, 60%, 22.2%, and 0% for 5% NaF varnish.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SDF demonstrated greater effectiveness than NaF varnish in arresting interproximal caries in primary molars, particularly in lesions involving dentin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_177_25","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:00:25Z","timestamp":1759251625000},"page":"389-395","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Arrest of interproximal caries lesion in primary molars with 38% silver diamine fluoride solution and 5% sodium fluoride varnish: A randomized clinical trial"],"prefix":"10.4103","volume":"43","author":[{"given":"Ruchi","family":"Singhal","sequence":"first","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shefali","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Namdev","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himani","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, 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