{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:47:53Z","timestamp":1787071673840,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n Background:<\/jats:title>\n Vital pulp therapy is crucial for preserving primary teeth vitality in deep carious lesions. Silver diamine fluoride (SDF) and biodentine are emerging materials with promising biological and therapeutic outcomes.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The aim of the study was to evaluate and compare the clinical, radiographic, and histological outcomes of SDF and biodentine for indirect pulp therapy in primary molars.<\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n \n This two-phase study included\n in vivo<\/jats:italic>\n clinical and radiographic evaluation (Phase 1) and an\n ex vivo<\/jats:italic>\n histological assessment (Phase 2). A split-mouth randomized controlled trial was conducted involving 68 children (4\u20137 years) with deep carious lesions approaching the pulp in primary molars. A total of 136 teeth were included, forming 68 matched pairs.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Phase 1: Participants were randomly assigned to Group 1 (SDF \u2013 Test,\n n<\/jats:italic>\n = 68) and Group 2 (Biodentine \u2013 Control,\n n<\/jats:italic>\n = 68). Following caries excavation, 38% SDF or biodentine was applied. All treated teeth were restored with glass ionomer cement and evaluated clinically and radiographically at 3, 6, and 9 months. Phase 2: Teeth extracted for orthodontic reasons were histologically examined for dentin bridge formation, pulpal inflammation, and tissue integrity.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n \n Data were analyzed using SPSS v23.0. Chi-square test and Fisher\u2019s exact test were applied.\n P<\/jats:italic>\n <0.05 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n At 9 months, Group 2 showed higher clinical success (85.3%) than Group 1 (77.9%) (\n P<\/jats:italic>\n = 0.035). Radiographic success was greater in Group 2 (83.8%) compared to Group 1 (70.6%) (\n P<\/jats:italic>\n = 0.01). Histological findings favored biodentine.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Both materials were effective, but biodentine demonstrated superior clinical and biological outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_198_25","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:00:30Z","timestamp":1759251630000},"page":"380-388","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of silver diamine fluoride and biodentine as agents for indirect pulp therapy in primary teeth \u2013 A randomized controlled trial"],"prefix":"10.4103","volume":"43","author":[{"given":"Daya","family":"Srinivasan","sequence":"first","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Chettinad Dental College and Research Institute, Kelambakkam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoba","family":"Narayan","sequence":"additional","affiliation":[{"name":"Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanthi","family":"Mungara","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Shreya","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Chettinad Dental College and Research Institute, Kelambakkam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"R1-20251001","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/iej.13128","article-title":"Management of deep caries and the exposed pulp","volume":"52","author":"Bj\u00f8rndal","year":"2019","journal-title":"Int Endod J"},{"key":"R2-20251001","doi-asserted-by":"crossref","first-page":"68","DOI":"10.17796\/jcpd.31.2.y4um5076341226m5","article-title":"Indirect pulp capping in the primary dentition: A 4 year follow-up study","volume":"31","author":"Marchi","year":"2006","journal-title":"J Clin Pediatr Dent"},{"key":"R4-20251001","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/iej.12906","article-title":"Disclosing the physiology of pulp tissue for vital pulp therapy","volume":"51","author":"da Rosa","year":"2018","journal-title":"Int Endod 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