{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:40:35Z","timestamp":1788550835573,"version":"build-2803163510"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n Context:<\/jats:title>\n Effective local anesthesia is essential in pediatric dentistry, especially during procedures like pulpectomy. While lignocaine with adrenaline is widely used, mepivacaine without a vasoconstrictor offers potential benefits in pediatric patients.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n This study aimed to compare the hemodynamic responses and pain perception associated with 3% mepivacaine (plain) versus 2% lignocaine with 1:100,000 adrenaline in children undergoing pulpectomy.<\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n A randomized, double-blind controlled trial was conducted at the Department of Pediatric and Preventive Dentistry of Dr. R. Ahmed Dental College and Hospital, Kolkata, India.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Fifty children aged 6\u201313 years with symptomatic irreversible pulpitis were randomly assigned to receive either mepivacaine or lignocaine through buccal infiltration. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and intraoperative pain (Wong\u2013Baker FACES Pain Rating Scale) were recorded at four time points (preoperatively, 5-, 15-, and 30-min postadministration).<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis Used:<\/jats:title>\n \n Comparisons within the group over different time points were performed using Friedman\u2019s test, while intergroup comparisons at each time point were assessed using the Mann\u2013Whitney\n U<\/jats:italic>\n -test. All analyses were conducted with the significance level set at 5%.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mepivacaine group showed significantly lower HR at T1 (\n P<\/jats:italic>\n < 0.0001) and reduced postoperative pain scores (\n P<\/jats:italic>\n = 0.0046). SBP and DBP changes were less pronounced compared to lignocaine, though not statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Mepivacaine without vasoconstrictor provided effective anesthesia with better hemodynamic stability and pain control, supporting its use as a safe alternative in pediatric endodontics, especially where epinephrine use is undesirable.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_238_25","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:00:38Z","timestamp":1759251638000},"page":"396-403","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparative evaluation of 3% plain mepivacaine and 2% lignocaine with 1:100,000 adrenaline in the pediatric population: A double-blind, randomized controlled trial"],"prefix":"10.4103","volume":"43","author":[{"given":"Rachita","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuti","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"R1-20251001","doi-asserted-by":"crossref","first-page":"39","DOI":"10.18773\/austprescr.2020.010","article-title":"Management of dental pain in primary care","volume":"43","author":"Timmerman","year":"2020","journal-title":"Aust Prescr"},{"key":"R2-20251001","doi-asserted-by":"crossref","first-page":"74","DOI":"10.17796\/jcpd.39.1.g12782873611827u","article-title":"Lidocaine versus mepivacaine in sedated pediatric dental patients: Randomized, prospective clinical study","volume":"39","author":"\u00c7al\u0131\u015f","year":"2014","journal-title":"J Clin Pediatr Dent"},{"key":"R3-20251001","first-page":"148","article-title":"Local anaesthesia in paediatric dentistry: A literature review on current alternative techniques and 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children","volume":"16","author":"Nayak","year":"2024","journal-title":"Asian J Pharm Res Health Care"},{"key":"R14-20251001","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.14219\/jada.archive.1995.0082","article-title":"Assessing the duration of mandibular soft tissue anesthesia","volume":"126","author":"Hersh","year":"1995","journal-title":"J Am Dent Assoc"},{"key":"R15-20251001","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0011-8532(02)00020-4","article-title":"Local anesthesia: Advances in agents and techniques","volume":"46","author":"Hawkins","year":"2002","journal-title":"Dent Clin North Am"},{"key":"R16-20251001","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0099-2399(06)80510-8","article-title":"An evaluation of 4% prilocaine and 3% mepivacaine compared with 2% lidocaine (1:100,000 epinephrine) for inferior alveolar nerve block","volume":"19","author":"McLean","year":"1993","journal-title":"J 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