{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:25:17Z","timestamp":1787772317422,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"\n Objective:<\/jats:title>\n The objective of the study is to determine the association between nonsyndromic oral clefts (OC) in children and ABO, Rh blood groups, lip, and dermatoglyphic patterns of their unaffected parents.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This case\u2013control study was conducted at a tertiary cleft center in Chennai, India, among 240 individuals comprising 80 units (40 cases and controls, respectively). Each unit (triad) was constituted by a child (0\u201312 years of age) either born with nonsyndromic OC (cases) or with no diagnosed congenital anomaly (control) and their unaffected parents (mother and father). ABO and Rh blood groups, specific lip print, fingerprint pattern, and palmar asymmetry were recorded for each individual. Strength of association of related factors was assessed by multivariable logistic regression reported as adjusted odds ratios and 95% confidence interval.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A\n 1<\/jats:sub>\n -positive blood group was found to be considerably higher among case mothers (14.39 [1.57\u201332.27]). A higher odds of OCs were observed among case mothers with whorl lip pattern (1.51 [1.16\u20133.17]) and radial loop pattern in fingers (1.44 [1.09\u20132.31]) relative to controls. In addition, palmar asymmetry was distinctively higher among case parents compared to controls (\n P<\/jats:italic>\n < 0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Findings indicate that A\n 1<\/jats:sub>\n -positive blood group, higher frequency of whorl lip, and radial loop finger patterns in mothers and higher ulnar loop pattern in fathers and palmar asymmetry in both parents increases odds of occurrence of OC among their offspring. These identifiable traits offer potential scope for better service planning among resource-constrained disadvantaged communities in India.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_23_21","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T04:57:45Z","timestamp":1716267465000},"page":"9-15","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Association between ABO, Rh blood groups, lip and dermatoglyphic patterns, and nonsyndromic oral clefts"],"prefix":"10.4103","volume":"39","author":[{"given":"Nimisha","family":"Sivanand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Junaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Sivapathasundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikandhan","family":"Ramanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann F","family":"Sailer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JE","family":"Nijesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Sivasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetha Elizabeth","family":"Chaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20240905","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/ajmg.c.31381","article-title":"Genetics of cleft lip and cleft palate","volume":"163C","author":"Leslie","year":"2013","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"R2-3-20240905","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00784-017-2102-6","article-title":"Association between maternal exposure to tobacco, presence of TGFA gene, and the occurrence of oral clefts. A case control study","volume":"22","author":"Junaid","year":"2018","journal-title":"Clin Oral Investig"},{"key":"R3-3-20240905","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4103\/0970-4388.175512","article-title":"Cheiloscopy and dermatoglyphics as genetic markers in the transmission of cleft lip and palate: A case-control study","volume":"34","author":"Saujanya","year":"2016","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"R4-3-20240905","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.4103\/0970-0358.57182","article-title":"Addressing the challenges of cleft lip and palate research in India","volume":"42","author":"Mossey","year":"2009","journal-title":"Indian J Plast Surg"},{"key":"R5-3-20240905","doi-asserted-by":"crossref","first-page":"e0118961","DOI":"10.1371\/journal.pone.0118961","article-title":"Birth prevalence of neural tube defects and orofacial clefts in India: A systematic review and meta-analysis","volume":"10","author":"Allagh","year":"2015","journal-title":"PLoS One"},{"key":"R6-3-20240905","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/aje\/kwi214","article-title":"Cleft lip and palate versus cleft lip only: Are they distinct defects?","volume":"162","author":"Harville","year":"2005","journal-title":"Am J Epidemiol"},{"key":"R7-3-20240905","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/0970-0358.53004","article-title":"Current concepts in genetics of nonsyndromic clefts","volume":"42","author":"Murthy","year":"2009","journal-title":"Indian J Plast Surg"},{"key":"R8-3-20240905","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1597\/12-209","article-title":"Parental consanguinity and nonsyndromic orofacial clefts in children: A systematic review and meta-analyses","volume":"51","author":"Sabbagh","year":"2014","journal-title":"Cleft Palate Craniofac J"},{"key":"R9-3-20240905","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/01.ede.0000158745.84019.c2","article-title":"Parent's age and the risk of oral clefts","volume":"16","author":"Bille","year":"2005","journal-title":"Epidemiology"},{"key":"R10-3-20240905","first-page":"78","article-title":"Family history and risk factors for cleft lip and palate patients and their associated anomalies","volume":"19","author":"Jamilian","year":"2017","journal-title":"Stomatologija"},{"key":"R11-3-20240905","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/01.ede.0000259986.85239.87","article-title":"Maternal stressful life events and risks of birth defects","volume":"18","author":"Carmichael","year":"2007","journal-title":"Epidemiology"},{"key":"R12-3-20240905","doi-asserted-by":"crossref","first-page":"S170","DOI":"10.1097\/01.AOG.0000514098.03289.66","article-title":"Effect of assisted reproductive technology on the occurrence of birth defects: A population-based study [25P]","volume":"129","author":"Maor","year":"2017","journal-title":"Obstetr Gynecol"},{"key":"R13-3-20240905","first-page":"572","article-title":"Serological and biochemical genetic markers in congenital cleft lip and cleft palate anomalies","volume":"22","author":"Balgir","year":"1986","journal-title":"Isr J Med Sci"},{"key":"R14-3-20240905","first-page":"234","article-title":"Lip prints (cheiloscopy)","volume":"12","author":"Sivapathasundharam","year":"2001","journal-title":"Indian J Dent Res"},{"key":"R15-3-20240905","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0300-9432(74)90034-X","article-title":"Studies on personal identification by means of lip prints","volume":"3","author":"Tsuchihashi","year":"1974","journal-title":"Forensic Sci"},{"key":"R16-3-20240905","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1001\/archderm.1967.01610060115023","article-title":"Fundamentals of dermatoglyphics","volume":"96","author":"Gibbs","year":"1967","journal-title":"Arch Dermatol"},{"key":"R17-3-20240905","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1597\/04-040.1","article-title":"Dermatoglyphic pattern types in subjects with nonsyndromic cleft lip with or without cleft palate (CL\/P) and their unaffected relatives in the Philippines","volume":"42","author":"Scott","year":"2005","journal-title":"Cleft Palate Craniofac J"},{"key":"R18-3-20240905","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1597\/08-045.1","article-title":"Dermatoglyphic analysis in parents with nonfamilial bilateral cleft lip and palate children","volume":"47","author":"Jahanbin","year":"2010","journal-title":"Cleft Palate Craniofac J"},{"key":"R19-3-20240905","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1597\/15-168","article-title":"Dermatoglyphics and cheiloscopy as key tools in resolving the genetic correlation of inheritance patterns in cleft lip and palate patients: An assessment of 160 patients","volume":"54","author":"Singh","year":"2017","journal-title":"Cleft Palate Craniofac J"},{"key":"R20-3-20240905","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/2249-4863.130248","article-title":"A Critical Appraisal of Kuppuswamy's Socioeconomic Status Scale in the Present Scenario","volume":"3","author":"Sharma","year":"2014","journal-title":"Journal of family medicine and primary care"},{"key":"R21-3-20240905","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00006534-197105000-00010","article-title":"The striped Y--a symbolic classification for cleft lip and palate","volume":"47","author":"Kernahan","year":"1971","journal-title":"Plast Reconstr Surg"},{"key":"R22-3-20240905","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/s16010051","article-title":"Blood Group Typing: From Classical Strategies to the Application of Synthetic Antibodies Generated by Molecular Imprinting","volume":"16","author":"Mujahid","year":"2015","journal-title":"Sensors (Basel, Switzerland"},{"key":"R24-3-20240905","first-page":"ZC28","article-title":"Lip prints and inheritance of cleft lip and cleft palate","volume":"8","author":"Cj","year":"2014","journal-title":"Journal of clinical and diagnostic research: JCDR"},{"key":"R25-3-20240905","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1002\/ajmg.a.33089","article-title":"Whorl patterns on the lower lip are associated with nonsyndromic cleft lip with or without cleft palate","volume":"149A","author":"Neiswanger","year":"2009","journal-title":"Am J Med Genet A"},{"key":"R26-3-20240905","first-page":"1","article-title":"Relationship between genetic anomalies of different levels and deviations in dermatoglyphic traits. Part 6: Dermatoglyphic peculiarities of males and females with cleft lip (with or without cleft palate) and cleft palate--family study","volume":"23","author":"Kobyliansky","year":"1999","journal-title":"Coll Antropol"},{"key":"R27-3-20240905","doi-asserted-by":"crossref","first-page":"e0230534","DOI":"10.1371\/journal.pone.0230534","article-title":"Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns","volume":"15","author":"Neiswanger","year":"2020","journal-title":"PLoS One"},{"key":"R28-3-20240905","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/0970-4388.19005","article-title":"Dermatoglyphic peculiarities in children with oral clefts","volume":"23","author":"Mathew","year":"2005","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"R29-3-20240905","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1597\/14-136","article-title":"Environmental risk factors in the etiology of nonsyndromic orofacial clefts in the western region of Saudi Arabia","volume":"53","author":"Sabbagh","year":"2016","journal-title":"Cleft Palate Craniofac J"},{"key":"R30-3-20240905","first-page":"531","article-title":"Nutritional disparities among women in urban India","volume":"31","author":"Agarwal","year":"2013","journal-title":"J Health Popul Nutr"}],"container-title":["Journal of Indian Society of Pedodontics and Preventive Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jisppd.jisppd_23_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:38:14Z","timestamp":1787769494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jisppd.jisppd_23_21"}},"subtitle":["A case\u2013control study"],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jisppd.jisppd_23_21","relation":{},"ISSN":["0970-4388"],"issn-type":[{"value":"0970-4388","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}