{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:09Z","timestamp":1787070909045,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Nano silver fluoride (NSF) can be used to prevent and arrest caries. The release of silver, fluoride combined with calcium, phosphate ions within the saliva will reinforce the antimicrobial and remineralization of carious lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the bioavailability of ions in saliva of children with early childhood caries (ECC) at different time intervals at pre- and post-application of NSF varnish.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Sixty saliva samples were collected from 20 ECC children as follows: pretreatment before the application of NSF (T0), posttreatment after the application of NSF at 1 day (T1), and posttreatment after the application of NSF at 15 days (T2). Samples were then subjected to ion analysis (fluoride ion in ppm using ultraviolet-visible spectrophotometer and silver, calcium, phosphorous ion in ppm using inductively coupled plasma optical emission Spectrophotometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results of the study showed that the mean ions concentration was significantly higher in T1 &gt;T2&gt;T0 which is statistically significant at\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The bioavailability of ions increased after application of NSF in the present study. In conclusion, NSF is an effective anti-caries agent in young children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_24_25","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T09:00:29Z","timestamp":1751274029000},"page":"284-290","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Bioavailability of ions in saliva after the application of nano silver fluoride in children with early childhood caries: An ex vivo study"],"prefix":"10.4103","volume":"43","author":[{"given":"Berin N. 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