{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:43:28Z","timestamp":1786725808850,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Oral application of sweet-tasting solutions has found to be effective in minimizing pain on dental injection in children. Xylitol has never been tested in this regard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this study was to compare the effectiveness of prior application of sucrose versus xylitol solution in minimizing pain on dental injection in 5\u20137-year-old children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>This study was a randomized controlled clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Informed consent was taken. A total of 30 children who required maxillary buccal infiltration injection were selected. The children were randomly allocated into the sucrose group, xylitol group, or control group by lottery method. In the sucrose and xylitol groups, 30% sucrose or 30% xylitol solution was applied on the lateral surface of the tongue for 2 min. In the control group, distilled water was applied. In all the groups, the topical anesthetic was applied at the site of injection followed by buccal infiltration. A video was taken during injection, and the sound eye-motor (SEM) scale was recorded by a blinded examiner. Patients were asked to self-evaluate using the Wong\u2013Baker Faces Pain Scale (WBFPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>Mann\u2013Whitney test was used to analyze the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was a statistically significant difference in the WBFPS and the SEM score between the sucrose and the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) and the xylitol and control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). No statistically significant difference was found between the sucrose and xylitol group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The application of xylitol solution before dental injection was as effective as sucrose solution in minimizing pain during the injection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_250_23","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T10:17:15Z","timestamp":1697537835000},"page":"216-221","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of the effectiveness of sucrose versus xylitol application in minimizing pain related to dental injection in 5\u20137-year-old children \u2013 A randomized controlled pilot study"],"prefix":"10.4103","volume":"41","author":[{"given":"J. Jasmin","family":"Winnier","sequence":"first","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, D.Y.Patil University, School of Dentistry, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishani","family":"Ratnaparkhi","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, D.Y.Patil University, School of Dentistry, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amil","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, D.Y.Patil University, School of Dentistry, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaineb","family":"Haradwala","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, D.Y.Patil University, School of Dentistry, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Manoj","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, D.Y.Patil University, School of Dentistry, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa S.","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, D.Y.Patil University, School of Dentistry, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"R1-20240905","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ana.22267","article-title":"Procedural pain and brain development in premature newborns","volume":"71","author":"Brummelte","year":"2012","journal-title":"Ann Neurol"},{"key":"R2-20240905","first-page":"790","article-title":"Effect of pre-cooling injection site on pain perception in pediatric dentistry:A randomized clinical trial","volume":"10","author":"Ghaderi","year":"2013","journal-title":"Dent Res J (Isfahan)"},{"key":"R3-20240905","doi-asserted-by":"crossref","first-page":"187","DOI":"10.17245\/jdapm.2020.20.4.187","article-title":"Effect of warming local anesthesia solutions before intraoral administration in dentistry:A systematic review","volume":"20","author":"Tirupathi","year":"2020","journal-title":"J Dent Anesth Pain Med"},{"key":"R4-20240905","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/0970-4388.160343","article-title":"Effectiveness of new vibration delivery system on pain associated with injection of local anesthesia in children","volume":"33","author":"Shilpapriya","year":"2015","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"R5-20240905","first-page":"e35","article-title":"Effectiveness of new distraction technique on pain associated with injection of local anesthesia for children","volume":"34","author":"El-Sharkawi","year":"2012","journal-title":"Pediatr Dent"},{"key":"R6-20240905","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/ipd.12936","article-title":"Effects of low level laser therapy on injection pain and anesthesia efficacy during local anesthesia in children:A randomized clinical trial","volume":"32","author":"U\u00e7ar","year":"2022","journal-title":"Int J Paediatr Dent"},{"key":"R7-20240905","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/ipd.12580","article-title":"Does computerized anaesthesia reduce pain during local anaesthesia in paediatric patients for dental treatment?A systematic review and meta-analysis","volume":"30","author":"Smolarek","year":"2020","journal-title":"Int J Paediatr Dent"},{"key":"R8-20240905","first-page":"CD011024","article-title":"Interventions for increasing acceptance of local anesthetic in children and adolescents having dental treatment","volume":"2","author":"Monteiro","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"R9-20240905","first-page":"CD001069","article-title":"Sucrose for analgesia in newborn infants undergoing painful procedures","volume":"7","author":"Stevens","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"R10-20240905","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(10)61303-7","article-title":"Oral sucrose as an analgesic drug for procedural pain in newborn infants:A randomised controlled trial","volume":"376","author":"Slater","year":"2010","journal-title":"Lancet"},{"key":"R11-20240905","first-page":"CD008408","article-title":"Sweet tasting solutions for reduction of needle-related procedural pain in children aged one to 16 years","volume":"2015","author":"Harrison","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"R12-20240905","doi-asserted-by":"crossref","first-page":"445","DOI":"10.5055\/jom.2010.0043","article-title":"The relationship between opioid and sugar intake:Review of evidence and clinical applications","volume":"6","author":"Mysels","year":"2010","journal-title":"J Opioid Manag"},{"key":"R13-20240905","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/ipd.12697","article-title":"The efficacy of administrating a sweet-tasting solution for reducing the pain related to dental injections in children:A randomized controlled trial","volume":"31","author":"Ghaderi","year":"2021","journal-title":"Int J Paediatr Dent"},{"key":"R14-20240905","first-page":"1434","article-title":"Effectiveness of pre-administered natural sweet-tasting solution for decreasing pain associated with dental injections in children:A split-mouth randomized controlled trial","volume":"22","author":"Janiani","year":"2021","journal-title":"J Contemp Dent Pract"},{"key":"R15-20240905","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1734-1140(12)70767-3","article-title":"Evaluation and comparison of antinociceptive activity of aspartame with sucrose","volume":"64","author":"Rani","year":"2012","journal-title":"Pharmacol Rep"},{"key":"R16-20240905","first-page":"CD010743","article-title":"Xylitol-containing products for preventing dental caries in children and adults","volume":"2015","author":"Riley","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"R17-20240905","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0091-3057(91)90034-Y","article-title":"Dietary influences on morphine-induced analgesia in rats","volume":"38","author":"Kanarek","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"key":"R18-20240905","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0091-3057(96)00227-4","article-title":"Beyond sweet taste:Saccharin, sucrose, and polycose differ in their effects upon morphine-induced analgesia","volume":"56","author":"D'Anci","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"key":"R19-20240905","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/phrs.2000.0682","article-title":"Saccharin effects on morphine-induced antinociception in the mouse formalin test","volume":"42","author":"Abdollahi","year":"2000","journal-title":"Pharmacol Res"},{"key":"R20-20240905","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0091-3057(00)00251-3","article-title":"Modulation of morphine-induced antinociception by palatable solutions in male and female rats","volume":"66","author":"Kanarek","year":"2000","journal-title":"Pharmacol Biochem Behav"},{"key":"R21-20240905","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuroscience.2005.01.055","article-title":"A brainstem substrate for analgesia elicited by intraoral sucrose","volume":"133","author":"Anseloni","year":"2005","journal-title":"Neuroscience"},{"key":"R22-20240905","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1136\/bmj.319.7222.1393","article-title":"Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates","volume":"319","author":"Carbajal","year":"1999","journal-title":"BMJ"},{"key":"R23-20240905","doi-asserted-by":"crossref","first-page":"F166","DOI":"10.1136\/adc.2005.087668","article-title":"Sucrose and non-nutritive sucking for the relief of pain in screening for retinopathy of prematurity:A randomised controlled trial","volume":"91","author":"Boyle","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"R24-20240905","doi-asserted-by":"crossref","first-page":"V","DOI":"10.2307\/1166096","article-title":"A new look at some old mechanisms in human newborns:Taste and tactile determinants of state, affect, and action","volume":"59","author":"Blass","year":"1994","journal-title":"Monogr Soc Res Child Dev"},{"issue":"Suppl 2","key":"R25-20240905","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1542\/peds.2006-0913R","article-title":"Sucrose analgesia:Identifying potentially better practices","volume":"118","author":"Lefrak","year":"2006","journal-title":"Pediatrics"},{"key":"R26-20240905","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1155\/2006\/197616","article-title":"Children's self-reports of pain intensity:Scale selection, limitations and interpretation","volume":"11","author":"von Baeyer","year":"2006","journal-title":"Pain Res Manag"},{"key":"R27-20240905","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-3959(90)90018-9","article-title":"The faces pain scale for the self-assessment of the severity of pain experienced by children:Development, initial validation, and preliminary investigation for ratio scale properties","volume":"41","author":"Bieri","year":"1990","journal-title":"Pain"},{"key":"R28-20240905","first-page":"278","article-title":"The effectiveness of infiltration anesthesia in the mandibular primary molar region","volume":"13","author":"Wright","year":"1991","journal-title":"Pediatr Dent"},{"key":"R29-20240905","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0304-3959(94)90092-2","article-title":"The cold pressor test in children:Methodological aspects and the analgesic effect of intraoral sucrose","volume":"56","author":"Miller","year":"1994","journal-title":"Pain"},{"key":"R30-20240905","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1542\/peds.2011-3848","article-title":"Sucrose for procedural pain management in infants","volume":"130","author":"Harrison","year":"2012","journal-title":"Pediatrics"}],"container-title":["Journal of Indian Society of Pedodontics and Preventive Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jisppd.jisppd_250_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:25:58Z","timestamp":1786724758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jisppd.jisppd_250_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jisppd.jisppd_250_23","relation":{},"ISSN":["0970-4388","1998-3905"],"issn-type":[{"value":"0970-4388","type":"print"},{"value":"1998-3905","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2023-05-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}