{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:48:00Z","timestamp":1787071680326,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n Background:<\/jats:title>\n Visually impaired children face unique challenges in maintaining oral hygiene, leading to higher risks of gingivitis. Chlorhexidine (CHX), photobiomodulation (PBM), and nanocurcumin offer potential adjunctive therapies, but their comparative efficacy in this population remains unexplored. Hence, the aim of the study is to evaluate and compare the effectiveness of CHX gel, PBM therapy, and oral nanocurcumin in managing gingivitis in visually impaired children.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n \n This double-blinded randomized controlled trial included 60 visually impaired children aged 8\u201314 years with mild to moderate gingivitis. Participants were allocated into three groups (\n n<\/jats:italic>\n = 20 each): Group A consisted of CHX gel (0.2%) applied twice daily, Group B with PBM using 980 nm diode laser on days 0 and 7, and Group C by oral nanocurcumin capsules (30 mg daily for 7 days). Plaque Index (PI) and Gingival Index (GI) were assessed at baseline, Days 7, 14, and 21. Data were analyzed using ANOVA and\n post hoc<\/jats:italic>\n tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n All groups experienced significant reductions in PI and GI (\n P<\/jats:italic>\n < 0.001). Nanocurcumin showed the greatest decreases (PI: 52.5%; GI: 68.6%), followed by PBM (PI: 37.5%; GI: 54.5%) and CHX (PI: 22.7%; GI: 30.9%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Oral nanocurcumin demonstrated superior efficacy in reducing gingivitis among visually impaired children, offering a promising noninvasive alternative to traditional chemical and mechanical approaches.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_280_25","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:00:48Z","timestamp":1759251648000},"page":"418-424","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative evaluation of novel nano-herbal and photo-biomodulation therapy for gingivitis in visually impaired children: A randomized controlled study"],"prefix":"10.4103","volume":"43","author":[{"given":"Santhebachalli Prakasha","family":"Shrutha","sequence":"first","affiliation":[{"name":"Department of Pedodontics, AMEs Dental College, Raichur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavendra","family":"Havale","sequence":"additional","affiliation":[{"name":"Department of Pedodontics, AMEs Dental College, Raichur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadlapalli Vineela","family":"Chowdary","sequence":"additional","affiliation":[{"name":"Department of Pedodontics, AMEs Dental College, Raichur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashyap","family":"Balkattu","sequence":"additional","affiliation":[{"name":"Department of Pedodontics, AMEs Dental College, Raichur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittal Sai","family":"Siddanatham","sequence":"additional","affiliation":[{"name":"Department of Pedodontics, AMEs Dental College, Raichur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"R1-20251001","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/0970-4388.84680","article-title":"Oral health knowledge, practice, oral hygiene status, and dental caries prevalence among visually impaired children in Bangalore","volume":"29","author":"Prashanth","year":"2011","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"R2-20251001","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-051X.2005.00875.x","article-title":"Gingivitis, dental caries and tooth loss: Risk factors for cardiovascular diseases or indicators of elevated health risks","volume":"33","author":"Yl\u00f6stalo","year":"2006","journal-title":"J Clin Periodontol"},{"key":"R3-20251001","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1600-051X.1989.tb01674.x","article-title":"Gingival health and gingivitis development during puberty. A 4-year longitudinal study","volume":"16","author":"Mombelli","year":"1989","journal-title":"J Clin Periodontol"},{"key":"R4-20251001","doi-asserted-by":"crossref","first-page":"84","DOI":"10.22159\/ajpcr.2018.v11i7.24783","article-title":"Comparison of effect of Hiora mouthwash versus chlorhexidine mouthwash in gingivitis patients: A clinical trial","volume":"11","author":"Ramamurthy","year":"2018","journal-title":"Asian J Pharm Clin Res"},{"key":"R5-20251001","first-page":"1450","article-title":"Chlorhexidine mouthwash-a review","volume":"9","author":"Kumar","year":"2017","journal-title":"J Pharm Sci Res"},{"key":"R6-20251001","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1089\/pho.2017.4404","article-title":"Influence of photobiomodulation therapy on gingivitis induced by multi-bracket appliances: A split-mouth randomized controlled trial","volume":"36","author":"Stein","year":"2018","journal-title":"Photomed Laser Surg"},{"key":"R7-20251001","first-page":"1","article-title":"Curcumin: A herbal approach in the management of gingivitis","volume":"3","author":"Roopa","year":"2016","journal-title":"Rama Univ J Dent Sci"},{"key":"R8-20251001","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/cre2.330","article-title":"Oral nano-curcumin on gingival inflammation in patients with gingivitis and mild periodontitis","volume":"7","author":"Malekzadeh","year":"2021","journal-title":"Clin Exp Dent Res"},{"key":"R9-20251001","first-page":"3","article-title":"A modified gingival index for use in clinical trials","volume":"8","author":"Lobene","year":"1986","journal-title":"Clin Prev Dent"},{"key":"R10-20251001","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion","volume":"22","author":"Silness","year":"1964","journal-title":"Acta Odontol Scand"},{"key":"R11-20251001","first-page":"533","article-title":"Periodontal disease in pregnancy. i. prevalence and severity. 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