{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:48:48Z","timestamp":1787071728433,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A major factor influencing the outcome of primary molar pulpotomy is the pulp-dressing material used. This study aimed to evaluate the clinical and radiographic outcomes of primary molar pulpotomies using hyaluronic acid (HA) gel and mineral Trioxide Aggregate (MTA) as pulpotomy medicaments at 6 and 12 months follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 28 children aged 4\u20138 years were included. Thirty-two primary molar teeth with deep carious lesions, with no history of spontaneous pain or signs of irreversible pulpitis, were treated by pulpotomy by a single operator using either HA or MTA as the pulp-dressing material. All teeth were restored using glass-ionomer cement, followed by a stainless steel crown. Clinical and radiographic assessments were performed at the 3, 6, and 12 months by two independent evaluators. Statistical comparative analyses were performed using the Chi-square test, and Kaplan\u2013Meier plots were synthesized. Statistical significance was determined when\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 was obtained.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In each group, 15 teeth were analyzed after 12 months. The clinical success rates were 93% and 100%, while the radiographic success rates were 80% and 60% for the MTA and HA groups, respectively. Most radiographic failures in the HA group were seen at the 6\n                      <jats:sup>th<\/jats:sup>\n                      -month follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>HA was comparable to MTA as a pulp-dressing material when evaluated clinically and radiographically at the 3, 6, and 12 months\u2019 follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_419_25","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T12:00:14Z","timestamp":1763121614000},"page":"567-574","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative evaluation of clinical and radiographic outcomes of primary molar pulpotomy using hyaluronic acid and mineral trioxide aggregate: A randomized clinical trial"],"prefix":"10.4103","volume":"43","author":[{"given":"Joseph","family":"Lepcha","sequence":"first","affiliation":[{"name":"Department of Dentistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virat","family":"Galhotra","sequence":"additional","affiliation":[{"name":"Department of Dentistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mugilan","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Dentistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tundup","family":"Dolker","sequence":"additional","affiliation":[{"name":"Department of Dentistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhea","family":"Gandham","sequence":"additional","affiliation":[{"name":"Department of Dentistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Rathod","sequence":"additional","affiliation":[{"name":"Department of Dentistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Central Armed Police Forces Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"R2-20251117","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-263X.2012.01237.x","article-title":"A randomized study of sodium hypochlorite versus formocresol pulpotomy in primary molar teeth","volume":"23","author":"Ruby","year":"2013","journal-title":"Int J Paediatr Dent"},{"key":"R3-20251117","first-page":"CD003220","article-title":"Pulp treatment for extensive decay in primary teeth","volume":"5","author":"Sma\u00efl-Faugeron","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"R4-20251117","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00784-018-2472-4","article-title":"The evaluation of MTA and biodentine as a pulpotomy materials for carious exposures in primary teeth","volume":"23","author":"\u00c7elik","year":"2019","journal-title":"Clin Oral Investig"},{"key":"R5-20251117","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/iej.12841","article-title":"Mineral trioxide aggregate and other bioactive endodontic cements: An updated overview \u2013Part I: vital pulp therapy","volume":"51","author":"Parirokh","year":"2018","journal-title":"Int Endod J"},{"key":"R6-20251117","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joen.2010.12.004","article-title":"Vital pulp therapy in vital permanent teeth with cariously exposed pulp: A systematic review","volume":"37","author":"Aguilar","year":"2011","journal-title":"J Endod"},{"key":"R7-20251117","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.3390\/cells10112899","article-title":"Hyaluronan-based gel promotes human dental pulp stem cells bone differentiation by activating YAP\/TAZ pathway","volume":"10","author":"La Noce","year":"2021","journal-title":"Cells"},{"key":"R8-20251117","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.2147\/DDDT.S165440","article-title":"Current development of biodegradable polymeric materials for biomedical applications","volume":"12","author":"Song","year":"2018","journal-title":"Drug Des Devel Ther"},{"key":"R9-20251117","first-page":"280","article-title":"The effect of hydrogel hyaluronic acid on dentine sialophosphoprotein expression of human dental pulp stem cells","volume":"8","author":"Nugraheni","year":"2023","journal-title":"Eur Endod J"},{"key":"R10-20251117","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/00016357.2021.1998612","article-title":"A randomized clinical trial of hyaluronic acid gel pulpotomy in primary molars with 1 year follow-up","volume":"80","author":"Ilde\u015f","year":"2022","journal-title":"Acta Odontol Scand"},{"key":"R11-20251117","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.21608\/edj.2021.74238.1611","article-title":"Clinical and radiographic evaluation of hyaluronic acid as a vital pulpotomy medication in primary molars","volume":"67","author":"Mahfouz","year":"2021","journal-title":"Egypt Dent J"},{"key":"R12-20251117","doi-asserted-by":"crossref","first-page":"e081123","DOI":"10.1136\/bmj-2024-081123","article-title":"CONSORT 2025 statement: Updated guideline for reporting randomised trials","volume":"389","author":"Hopewell","year":"2025","journal-title":"BMJ"},{"key":"R13-20251117","first-page":"284","article-title":"The clinical and radiographic success of primary molar pulpotomy using biodentine\u2122and mineral trioxide aggregate: A 24-month randomized clinical trial","volume":"39","author":"Bani","year":"2017","journal-title":"Pediatr Dent"},{"key":"R14-20251117","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40368-015-0174-z","article-title":"Evidence of pulpotomy in primary teeth comparing MTA, calcium hydroxide, ferric sulphate, and electrosurgery with formocresol","volume":"16","author":"Stringhini Junior","year":"2015","journal-title":"Eur Arch Paediatr Dent"},{"key":"R15-20251117","first-page":"474","article-title":"Primary tooth vital pulp treatment interventions: Systematic review and meta-analyses","volume":"45","author":"Coll","year":"2023","journal-title":"Pediatr Dent"},{"key":"R16-20251117","doi-asserted-by":"crossref","first-page":"14","DOI":"10.17796\/1053-4628-40.1.14","article-title":"Clinical and radiographic evaluation of the effectiveness of formocresol, mineral trioxide aggregate, portland cement, and enamel matrix derivative in primary teeth pulpotomies: A two year follow-up","volume":"40","author":"Yildirim","year":"2016","journal-title":"J Clin Pediatr Dent"},{"key":"R17-20251117","doi-asserted-by":"crossref","first-page":"65","DOI":"10.7150\/ijms.6.65","article-title":"Esterified hyaluronic acid and autologous bone in the surgical correction of the infra-bone defects","volume":"6","author":"Ballini","year":"2009","journal-title":"Int J Med Sci"},{"key":"R18-20251117","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1601-5037.2007.00239.x","article-title":"Peri-implant maintenance of immediate function implants: A pilot study comparing hyaluronic acid and chlorhexidine","volume":"5","author":"de Ara\u00fajo Nobre","year":"2007","journal-title":"Int J Dent Hyg"},{"key":"R19-20251117","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4103\/jisp.jisp_674_18","article-title":"Single application of 0.8% hyaluronic acid as a coadjuvant of nonsurgical treatment in nonsmoking patients with periodontitis: A split-mouth, randomized, controlled pilot clinical trial","volume":"23","author":"Lobato","year":"2019","journal-title":"J Indian Soc Periodontol"},{"key":"R20-20251117","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10266-024-00973-7","article-title":"Histological evaluation of different concentrations of hyaluronic-acid-added zinc oxide eugenol on rat molar pulp","volume":"113","author":"Bektas","year":"2025","journal-title":"Odontology"},{"key":"R21-20251117","first-page":"782","article-title":"Ferric sulfate pulpotomy in primary teeth with different base materials: A 2-year randomized controlled trial","volume":"53","author":"Aksoy","year":"2022","journal-title":"Quintessence Int"},{"key":"R22-20251117","doi-asserted-by":"crossref","first-page":"312","DOI":"10.17796\/1053-4628-40.4.312","article-title":"Eugenol toxicity in human dental pulp fibroblasts of primary teeth","volume":"40","author":"Escobar-Garc\u00eda","year":"2016","journal-title":"J Clin Pediatr Dent"},{"key":"R23-20251117","first-page":"165","article-title":"Success rates of mineral trioxide aggregate, ferric sulfate, and formocresol pulpotomies: A 24-month study","volume":"33","author":"Erdem","year":"2011","journal-title":"Pediatr Dent"},{"key":"R24-20251117","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/iej.13080","article-title":"European society of endodontology position statement: Management of deep caries and the exposed pulp","volume":"52","author":"Duncan","year":"2019","journal-title":"Int Endod J"},{"key":"R25-20251117","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s40368-019-00493-x","article-title":"Best clinical practice guidance for prescribing dental radiographs in children and adolescents: An EAPD policy document","volume":"21","author":"K\u00fchnisch","year":"2020","journal-title":"Eur Arch Paediatr Dent"},{"key":"R26-20251117","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.5005\/jp-journals-10005-2216","article-title":"Clinical radiographic evaluation of 3Mixtatin and MTA in primary teeth pulpotomies: A randomized controlled","volume":"15","author":"Chak","year":"2022","journal-title":"Int J Clin Pediatr Dent"},{"key":"R27-20251117","first-page":"13","article-title":"Use of vital pulp therapies in primary teeth 2024","volume":"46","author":"Coll","year":"2024","journal-title":"Pediatr Dent"},{"key":"R28-20251117","first-page":"6","article-title":"A review on vital pulp therapy in primary teeth","volume":"10","author":"Parisay","year":"2015","journal-title":"Iran Endod J"},{"key":"R29-20251117","doi-asserted-by":"crossref","first-page":"447","DOI":"10.17796\/1053-4628-39.5.447","article-title":"Efficiency and reliability of thermal and electrical tests to evaluate pulp status in primary teeth with assessment of anxiety levels in children","volume":"39","author":"Nagarathna","year":"2015","journal-title":"J Clin Pediatr Dent"},{"key":"R30-20251117","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s00784-017-2098-y","article-title":"Pulp bleeding color is an indicator of clinical and histohematologic status of primary teeth","volume":"21","author":"Aminabadi","year":"2017","journal-title":"Clin Oral Investig"},{"key":"R31-20251117","first-page":"145","article-title":"Hemostasis in vital pulp therapy for children and adolescents: Does duration matter? A systematic review of randomized clinical trials","volume":"49","author":"Asgary","year":"2025","journal-title":"J Clin Pediatr Dent"}],"container-title":["Journal of Indian Society of Pedodontics and Preventive Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jisppd.jisppd_419_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:52:37Z","timestamp":1787068357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jisppd.jisppd_419_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jisppd.jisppd_419_25","relation":{},"ISSN":["0970-4388","1998-3905"],"issn-type":[{"value":"0970-4388","type":"print"},{"value":"1998-3905","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-09-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}