{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:32Z","timestamp":1787762012082,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Genetic polymorphisms of genes regulating amelogenesis can alter susceptibility to Early Childhood Caries (ECC). This systematic review aims to analyze associations between single-nucleotide polymorphisms of enamel formation genes and ECC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Search was conducted across PUBMED, CINAHL, LILACS, SCOPUS, EMBASE, Web of Science, Genome-Wide Association Studies databases from January 2003 to September 2022. This was supplemented by hand search. Totally 7124 articles were identified and 21 articles that satisfied the inclusion criteria proceeded to data extraction. Quality assessment was done using the Q-Genie tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Quantitative synthesis revealed that homozygous genotype AA of rs12640848 was significantly higher in children with ECC with an odds ratio of 2.36. Gene-based analysis revealed significant association between six variants of AMBN, four variants of KLK4, two variants of MMP20, and a single variant of each of MMP9 and MMP13 genes and ECC. The Bonferroni corrected-log10\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value of amelogenesis gene Cluster was 2.25 (0.05\/88 = 5.6 \u00d7 10\n                      <jats:sup>\u22124<\/jats:sup>\n                      ). Search Tool for Retrieval of Interacting Genes and Proteins plot constructed to comprehend the protein-protein interaction revealed the presence of four functional clusters. Gene function prediction using Multiple Association Network Integration Algorithm revealed that physical interaction between these genes was 69.3%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Polymorphisms of genes regulating amelogenesis can influence the susceptibility to ECC. AA genotype of rs12640848 may increase the susceptibility to ECC. Gene-based analysis revealed a significant association between multiple polymorphisms of genes regulating amelogenesis and ECC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jisppd.jisppd_78_23","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T10:01:15Z","timestamp":1685613675000},"page":"3-15","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Single nucleotide polymorphisms of enamel formation genes and early childhood caries - systematic review, gene-based, gene cluster and meta-analysis"],"prefix":"10.4103","volume":"41","author":[{"given":"Aruna","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Centre for Early Childhood Caries and Research, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"},{"name":"Department of Pediatric and Preventive Dentistry, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha S.","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Engineering, Faculty of Public Health, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"},{"name":"Department of Pediatric and Preventive Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Muthu","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Centre for Early Childhood Caries and Research, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"},{"name":"Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vettriselvi","family":"Venkatesan","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kirubakaran","sequence":"additional","affiliation":[{"name":"South Asian Cochrane Network and Centre, Christian Medical College, Vellore, Tamil Nadu, 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