{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:10:11Z","timestamp":1793581811714,"version":"4.5.0"},"reference-count":29,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":371,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>PURPOSE: The purpose of the study is to estimate the rate of infection with carbapenem-resistant Enterobacteriaceae (CRE) in the main governmental tertiary care hospital in Bahrain.<\/jats:p>\n                  <jats:p>MATERIALS AND METHODS: All clinical samples with positive growth of CRE over 6-year period (January 2012\u2013December 2017) were collected from the microbiology laboratory data.<\/jats:p>\n                  <jats:p>RESULTS: The CRE incidence was high in the first half of study period (2012\u20132014) and then decreased between 2015 and 2017, after implementation of intensified CRE control measure bundle. About 49.4% of CRE-positive samples were isolated from the elderly age group (above 65 years old), most of them were admitted in the intensive care unit (ICU). The most common isolated organisms were Klebsiella pneumoniae (87.0%), followed by Escherichia coli (7.9%). Isolates from deep tracheal aspirate and midstream urine specimens were the most common source of CRE isolates (27.3%) and (26.3%), respectively. Bacteremia was documented in 21.2% of cases. CRE isolates in the study showed high rates of resistance to aminoglycosides (72.2% resistant to amikacin and 67.3% to gentamicin). Alternatively, most isolates retained their susceptibility to colistin and tigecycline with sensitivity of 83.9% and 85.7%, respectively. Combined resistance to both colistin and tigecycline was observed in 0.06% of total isolates.<\/jats:p>\n                  <jats:p>CONCLUSION: Elderly population and ICU admission were important risk factors for CRE acquisition. Most of CRE isolates were sensitive to both colistin and tigecycline, which make them the best combination for empiric frontline therapy for suspected serious CRE infection in our facility. Implementing CRE-bundled infection control measures significantly reduced the incidence of CRE infection in our hospital.<\/jats:p>","DOI":"10.4103\/jlp.jlp_101_18","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T05:20:22Z","timestamp":1558588822000},"page":"111-117","source":"Crossref","is-referenced-by-count":28,"title":["Epidemiology of carbapenem-resistant Enterobacteriaceae in a Tertiary Care Center in the Kingdom of Bahrain"],"prefix":"10.25259","volume":"11","author":[{"given":"Nermin Kamal","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Pathology, Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa","family":"Alkhawaja","sequence":"additional","affiliation":[{"name":"Department of Infection Control, Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashawa Fawzy Abd El Moez","family":"Azam","sequence":"additional","affiliation":[{"name":"Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Alaradi","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Biltagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tanta University, Egypt and Arabian Gulf University, Bahrain, Kingdom of Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"key-10.4103\/0974-2727.258945-1","first-page":"20","volume-title":"Emergence of multidrug-resistant Providencia rettgeri isolates co-producing NDM-1 carbapenemase and PER-1 extended-spectrum \u03b2-lactamase causing a first outbreak in Korea","author":"Shin","year":"2018","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"key-10.4103\/0974-2727.258945-2","first-page":"376","volume-title":"Epidemiology of carbapenem resistant Enterobacteriaceae (CRE) during 2000-2012 in Asia","author":"Xu","year":"2015","journal-title":"J Thorac Dis"},{"key":"key-10.4103\/0974-2727.258945-3","first-page":"1288","volume-title":"Antimicrobial-resistant pathogens associated with healthcare-associated infections: Summary of data reported to the national healthcare safety network at the centers for disease control and prevention, 2011-2014","author":"Weiner","year":"2016","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key-10.4103\/0974-2727.258945-4","first-page":"1179","volume-title":"A step closer to extreme drug resistance (XDR) in Gram-negative Bacilli","author":"Paterson","year":"2007","journal-title":"Clin Infect Dis"},{"key":"key-10.4103\/0974-2727.258945-5","first-page":"E23","volume-title":"High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality","author":"Capone","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"key-10.4103\/0974-2727.258945-6","first-page":"54","volume-title":"Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections","author":"Ben-David","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"key-10.4103\/0974-2727.258945-7","first-page":"e0131372","volume-title":"Characterization of carbapenem-resistant Enterobacteriaceae with high rate of autochthonous transmission in the Arabian Peninsula","author":"Sonnevend","year":"2015","journal-title":"PLoS One"},{"key":"key-10.4103\/0974-2727.258945-8","first-page":"404","volume-title":"Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient","author":"Al-Qadheeb","year":"2010","journal-title":"Ann Saudi Med","ISSN":"https:\/\/id.crossref.org\/issn\/0256-4947","issn-type":"print"},{"key":"key-10.4103\/0974-2727.258945-9","first-page":"1901","volume-title":"The epidemiology of the first described carbapenem-resistant Klebsiella pneumoniae outbreak in a tertiary care hospital in Saudi Arabia: How far do we go?","author":"Balkhy","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key-10.4103\/0974-2727.258945-10","first-page":"E144","volume-title":"NDM-1, OXA-48 and OXA-181 carbapenemase-producing Enterobacteriaceae in sultanate of Oman","author":"Dortet","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"key-10.4103\/0974-2727.258945-11","first-page":"304","volume-title":"NDM-1-producing Klebsiella pneumoniae isolated in the sultanate of Oman","author":"Poirel","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"key-10.4103\/0974-2727.258945-12","first-page":"1044","volume-title":"Emergence and spread of NDM-1 producer Enterobacteriaceae with contribution of IncX3 plasmids in the United Arab Emirates","author":"Sonnevend","year":"2013","journal-title":"J Med Microbiol"},{"key":"key-10.4103\/0974-2727.258945-13","unstructured":"Facility Guideline for Control of Carbapenem-Resistant Enterobacteriaceae (CRE): CDC Update \u2013 CRE Toolkit; November, 2015. Available from: https:\/\/www.cdc.gov\/hai\/pdfs\/cre\/CRE-guidance-508.pdf. [Last accessed on 2018 May 28]."},{"key":"key-10.4103\/0974-2727.258945-14","first-page":"1295","volume-title":"Principles of assessing bacterial susceptibility to antibiotics using the agar diffusion method","author":"Bonev","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"key-10.4103\/0974-2727.258945-15","unstructured":"Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: 26nd Informational Supplement M100-S26. Wayne, PA: Clinical and Laboratory Standards Institute; 2016. Available from: http:\/\/www.facm.ucl.ac.be\/intranet\/CLSI\/CLSI-2017-M100-S27.pdf. [Last accessed on 2018 May 28]."},{"key":"key-10.4103\/0974-2727.258945-16","first-page":"6787","volume-title":"Results from the Canadian nosocomial infection surveillance program on carbapenemase-producing Enterobacteriaceae, 2010 to 2014","author":"Mataseje","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.4103\/0974-2727.258945-17","doi-asserted-by":"crossref","unstructured":"Zhang Y, Wang Q, Yin Y, Chen H, Jin L, Gu B, et al. Epidemiology of carbapenem-resistant Enterobacteriaceae infections: Report from the China CRE network. Antimicrob Agents Chemother 2018;62. pii: e01882-17.","DOI":"10.1128\/AAC.01882-17"},{"key":"key-10.4103\/0974-2727.258945-18","unstructured":"Government of Western Australia, Department of Public Health, Infection Prevention and Control of Carbapenem-resistant Enterobacteriaceae (CRE) in Western Australian Healthcare Facilities; 2012. Available from: http:\/\/www.health.wa.gov.au\/circularsnew\/attachments\/712.pdf. [Last accessed on 2018 May 02]."},{"key":"key-10.4103\/0974-2727.258945-19","unstructured":"Health Protection Agency. Department of Health Advisory Committee on Antimicrobial Resistance and Healthcare Associated Infection. Advice on Carbapenemase Producers: Recognition, Infection Control and Treatment. United Kingdom: Health Protection Agency; 2012. Available from: https:\/\/www.assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/707165\/ARHAI_annual_report_2014_to_2015.pdf. [Last accessed on 2018 May 28]."},{"key":"key-10.4103\/0974-2727.258945-20","first-page":"113","volume-title":"Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: Guidance from the European centre for disease prevention and control","author":"Magiorakos","year":"2017","journal-title":"Antimicrob Resist Infect Control"},{"key":"key-10.4103\/0974-2727.258945-21","first-page":"978","volume-title":", Moehring RW, et al. Rising rates of carbapenem-resistant Enterobacteriaceae in community hospitals: A mixed-methods review of epidemiology and microbiology practices in a network of community hospitals in the Southeastern United States","author":"Thaden","year":"2014","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key-10.4103\/0974-2727.258945-22","first-page":"55","volume-title":"Asystematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States","author":"Livorsi","year":"2018","journal-title":"Antimicrob Resist Infect Control"},{"key":"key-10.4103\/0974-2727.258945-23","first-page":"e295","volume-title":"Carbapenem-resistant Klebsiella pneumoniae endocarditis in a young adult.Successful treatment with gentamicin and colistin","author":"Benenson","year":"2009","journal-title":"Int J Infect Dis"},{"key":"key-10.4103\/0974-2727.258945-24","first-page":"32","volume-title":"Treatment of Klebsiella pneumoniae carbapenemase (KPC) infections: A review of published case series and case reports","author":"Lee","year":"2012","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"key-10.4103\/0974-2727.258945-25","first-page":"E23","volume-title":"High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality","author":"Capone","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"key-10.4103\/0974-2727.258945-26","first-page":"132","volume-title":"Emergence of carbapenem-resistant clinical Enterobacteriaceae isolates from a teaching hospital in Shanghai, China","author":"Hu","year":"2012","journal-title":"J Med Microbiol"},{"key":"key-10.4103\/0974-2727.258945-27","first-page":"DC18","volume-title":"Study on MICs of tigecycline in clinical isolates of carbapenem resistant Enterobacteriaceae (CRE) at a tertiary care centre in North India","author":"Khare","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"key-10.4103\/0974-2727.258945-28","first-page":"2609","volume-title":"Colistin and polymyxin B susceptibility testing for carbapenem-resistant and mcr-positive Enterobacteriaceae: Comparison of sensititre, microscan, vitek 2, and etest with broth microdilution","author":"Chew","year":"2017","journal-title":"J Clin Microbiol"},{"key":"key-10.4103\/0974-2727.258945-29","first-page":"S28","volume-title":"The epidemiology of carbapenem-resistant Enterobacteriaceae: The impact and evolution of a global menace","author":"Logan","year":"2017","journal-title":"J Infect Dis"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/JLP.JLP_101_18.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T03:16:03Z","timestamp":1703387763000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/epidemiology-of-carbapenem-resistant-enterobacteriaceae-in-a-tertiary-care-center-in-the-kingdom-of-bahrain\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":29,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,4,6]]},"published-print":{"date-parts":[[2019,4]]}},"URL":"https:\/\/doi.org\/10.4103\/jlp.jlp_101_18","relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}