{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:29:47Z","timestamp":1787030987966,"version":"build-2736575974"},"reference-count":23,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":963,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>INTRODUCTION: Bone marrow examination is a useful investigative tool for the diagnosis of many hematological and nonhematological disorders. Bone marrow aspiration (BMA) provides information about the numerical and cytological features of marrow cells, whereas bone marrow trephine biopsies (BMB) provide excellent appreciation of spatial relationships between cells and of overall bone marrow structure. We conducted this study with the objective of comparing the accuracy of BMA with BMB in the diagnosis of various hematological disorders.<\/jats:p>\n                  <jats:p>MATERIALS AND METHODS: Both BMA and BMB were performed on a total of 130 cases and a comparative evaluation was performed in 100 cases to see the complementary role of both the procedures. However, 30 cases were excluded due to inadequate BMA, BMB, or both. Immunohistochemistry (IHC) was employed whenever required.<\/jats:p>\n                  <jats:p>RESULTS: In our study of 100 cases, 87% of cases were confirmed on bone marrow biopsy and in remaining 13% of cases final diagnosis was achieved with the help of other ancillary investigations. These cases were excluded for calculation of concordance rate between BMA and BMB. The concordance and disconcordance rate between BMA and BMB was 72.4% and 27.6%, respectively.<\/jats:p>\n                  <jats:p>CONCLUSION: BMA cytology and trephine biopsy histopathology complement each other and the superiority of one method over the other depended on the underlying disorder. Furthermore, application of ancillary techniques such as flow cytometery and IHC proved to be an additional advantage in further typing of various diseases.<\/jats:p>","DOI":"10.4103\/jlp.jlp_117_16","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T07:28:37Z","timestamp":1497598117000},"page":"182-189","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of bone marrow aspiration cytology with bone marrow trephine biopsy histopathology: An observational study"],"prefix":"10.25259","volume":"9","author":[{"given":"Meenu","family":"Gilotra","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pt. BDS, PGIMS, University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pt. BDS, PGIMS, University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pt. BDS, PGIMS, University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pt. BDS, PGIMS, University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"key-10.4103\/0974-2727.208252-1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/9780470757130","volume-title":"Bone marrow aspiration","author":"Bain","year":"2001","journal-title":"J Clin Pathol"},{"key":"key-10.4103\/0974-2727.208252-2","first-page":"737","volume-title":"Bone marrow trephine biopsy","author":"Bain","year":"2001","journal-title":"J Clin Pathol"},{"key":"key-10.4103\/0974-2727.208252-3","first-page":"70","volume-title":"A pathologist's perspective on bone marrow aspiration and biopsy: I.Performing a bone marrow examination","author":"Riley","year":"2004","journal-title":"J Clin Lab Anal"},{"key":"key-10.4103\/0974-2727.208252-4","doi-asserted-by":"crossref","unstructured":"Bates I, Burthem J. Bone marrow biopsy. In: Bain BJ, Bates I, Laffan MA, Lewis SM, editors. Dacie and Lewis Practical Hematology. 11th ed. China: Elsevier, Churchill Livingstone; 2012. p. 123-37.","DOI":"10.1016\/B978-0-7020-3408-4.00007-2"},{"key":"key-10.4103\/0974-2727.208252-5","first-page":"1917","volume-title":"Prospective study of bone marrow in haematological disorders","author":"Atla","year":"2015","journal-title":"Int J Res Med Sci"},{"key":"key-10.4103\/0974-2727.208252-6","first-page":"e2014002","volume-title":"Comparative evaluation of bone marrow aspirate with trephine biopsy in hematological disorders and determination of optimum trephine length in lymphoma infiltration","author":"Goyal","year":"2014","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"key-10.4103\/0974-2727.208252-7","first-page":"247","volume-title":"Dry tap bone marrow aspiration: Clinical significance","author":"Humphries","year":"1990","journal-title":"Am J Hematol"},{"key":"key-10.4103\/0974-2727.208252-8","first-page":"194","volume-title":"Comparative evaluation of bone marrow aspirate particle smears, imprints and biopsy 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