{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:21:53Z","timestamp":1780338113235,"version":"3.54.1"},"reference-count":29,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":598,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          BACKGROUND: Candidal infections are an important cause of morbidity and mortality in Neonatal Intensive Care Unit. Neonatal candidiasis is increasing in frequency, mainly because of increase in the survival of babies with low-birth weight, preterm births, advancement in medical field, life support systems, relative immunodeficiency, and extensive use of broad-spectrum antibiotics. Over the past few decades, there has been a progressive shift from the predominance of Candida albicans to nonalbicans Candida species.<\/jats:p><jats:p>\n          AIMS AND OBJECTIVES: The objective of the current study was to know the prevalence of nonalbicans candidemia in neonates and their antifungal susceptibility pattern.<\/jats:p><jats:p>\n          Materials and Methods: In this study, a total of 424 samples from clinically diagnosed septicemic neonates were included. Identification of Candida isolates from these samples as well as their antifungal sensitivity testing was performed with Vitek 2 Compact (Biomerieux France) using Vitek 2 cards for identification of yeast and yeast-like organisms (ID-YST cards).<\/jats:p><jats:p>\n          Results: A total of 246\/424 (58.01%) cases were blood culture positive. Out of these, 80\/246 samples tested positive for candidemia (32.5%). Candida tropicalis (13.8%) was the predominant species isolated among the non-albicans Candida followed by Candida krusei (4.8%), Candida parapsilosis (3.2%), Candida guilliermondii (2.8%), and Candida dubliniensis (2.0%). We found an increase in the antifungal drug resistance, especially for the azole group of drugs, both in C. albicans and non-albicans Candida species. All the isolates were uniformly sensitive to micafungin, voriconazole, and caspofungin.<\/jats:p><jats:p>\n          Conclusions: Candidemia in neonates is an ominous prognostic sign and is an important entity in our region. The present study highlights the mycological shift of Candida species in neonatal candidemia with a preponderance of nonalbicans Candida species.<\/jats:p>","DOI":"10.4103\/jlp.jlp_1_18","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T05:03:48Z","timestamp":1530853428000},"page":"255-259","source":"Crossref","is-referenced-by-count":10,"title":["Spectrum of candidal species isolated from neonates admitted in an Intensive Care Unit of teaching hospital of Kashmir, North India"],"prefix":"10.25259","volume":"10","author":[{"given":"Asifa","family":"Nazir","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Masoodi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, SKIMS Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"key-10.4103\/0974-2727.236097-1","first-page":"86S","volume-title":"Secular trends in nosocomial primary bloodstream infections in the United States, 1980-1989.National Nosocomial Infections Surveillance System","author":"Banerjee","year":"1991","journal-title":"Am J Med"},{"key":"key-10.4103\/0974-2727.236097-2","first-page":"1526","volume-title":"Epidemiology of nosocomial fungal infections, with emphasis on Candida species","author":"Jarvis","year":"1995","journal-title":"Clin Infect Dis"},{"key":"key-10.4103\/0974-2727.236097-3","first-page":"59","volume-title":"Epidemiology of candidaemia at King Chulalongkorn Memorial Hospital, Thailand","author":"Tritipwanit","year":"2005","journal-title":"J Infect Dis Antimicrob Agents"},{"key":"key-10.4103\/0974-2727.236097-4","first-page":"607","volume-title":"Candidemia \u2013 An under-recognized nosocomial infection in Indian hospitals","author":"Sahni","year":"2005","journal-title":"J Assoc Physicians India"},{"key":"key-10.4103\/0974-2727.236097-5","first-page":"104","volume-title":"Epidemiology of systemic candidiasis in a tertiary care neonatal unit","author":"Narang","year":"1998","journal-title":"J Trop Pediatr"},{"key":"key-10.4103\/0974-2727.236097-6","first-page":"5","volume-title":"Candida glabrata emerging pathogen in neonatal sepsis","author":"Baradkar","year":"2008","journal-title":"Ann Trop Med Public Health","ISSN":"https:\/\/id.crossref.org\/issn\/1755-6783","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-7","first-page":"329","volume-title":"Epidemiology of candidiasis","author":"Pfaller","year":"1995","journal-title":"J Hosp Infect"},{"key":"key-10.4103\/0974-2727.236097-8","first-page":"160","volume-title":"Changing face of nosocomial candidaemia","author":"Chakrabarty","year":"1999","journal-title":"Indian J Med Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0255-0857","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-9","first-page":"1531","volume-title":"Nosocomial candidemia: Risk factors and attributable mortality","author":"Wenzel","year":"1995","journal-title":"Clin Infect Dis"},{"key":"key-10.4103\/0974-2727.236097-10","first-page":"712","volume-title":"Trends in neonatal septicemia: Emergence of non-albicans Candida","author":"Agarwal","year":"2004","journal-title":"Indian Pediatr"},{"key":"key-10.4103\/0974-2727.236097-11","doi-asserted-by":"crossref","unstructured":"McGinnis MR. Yeast identification. In: Laboratory Handbook of Medical Mycology. New York: Academic Press; 1980. p. 337-73.","DOI":"10.1016\/B978-0-12-482850-6.50009-5"},{"key":"key-10.4103\/0974-2727.236097-12","first-page":"143","volume-title":"Prevalence of systemic inflammatory syndromes at a tertiary pediatric Intensive Care Unit","author":"Carvalho","year":"2005","journal-title":"J Pediatr (Rio J)"},{"key":"key-10.4103\/0974-2727.236097-13","first-page":"144","volume-title":"Disseminated fungal infections in very low-birth-weight infants: Clinical manifestations and epidemiology","author":"Baley","year":"1984","journal-title":"Pediatrics"},{"key":"key-10.4103\/0974-2727.236097-14","first-page":"256","volume-title":"Epidemiology of candidemia in a tertiary care centre of North India: 5-year study","author":"Xess","year":"2007","journal-title":"Infection"},{"key":"key-10.4103\/0974-2727.236097-15","first-page":"601","volume-title":"Indentification of Candida species in neonatal septicemia","author":"Kapila","year":"2016","journal-title":"Int J Contemp Pediatr"},{"key":"key-10.4103\/0974-2727.236097-16","first-page":"263","volume-title":"Candida colonization in preterm babies admitted to neonatal Intensive Care Unit in the rural setting","author":"Mendiratta","year":"2006","journal-title":"Indian J Med Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0255-0857","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-17","first-page":"5848","volume-title":"Results from the ARTEMIS DISK Global Antifungal Surveillance Study: A 6.5-year analysis of susceptibilities of Candida and other yeast species to fluconazole and voriconazole by standardized disk diffusion testing","author":"Pfaller","year":"2005","journal-title":"J Clin Microbiol"},{"key":"key-10.4103\/0974-2727.236097-18","first-page":"319","volume-title":"Risk factors for candidemia in neonatal Intensive Care Unit patients.The National Epidemiology of Mycosis Survey Study Group","author":"Saiman","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"key-10.4103\/0974-2727.236097-19","first-page":"405","volume-title":"Candida spp.Other than Candida albicans: A major cause of fungaemia in a tertiary care centre","author":"Shivaprakasha","year":"2007","journal-title":"Indian J Med Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0255-0857","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-20","first-page":"122","volume-title":"Candidaemia in patients of a tertiary health care hospital from North India","author":"Verma","year":"2003","journal-title":"Indian J Med Res","ISSN":"https:\/\/id.crossref.org\/issn\/0971-5916","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-21","first-page":"414","volume-title":"Candidemia in a tertiary care hospital: Epidemiology, risk factors, and predictors of mortality","author":"Fraser","year":"1992","journal-title":"Clin Infect Dis"},{"key":"key-10.4103\/0974-2727.236097-22","first-page":"45","volume-title":"Candidemia in neonatal Intensive Care Unit","author":"Gupta","year":"2001","journal-title":"Indian J Pathol Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0377-4929","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-23","first-page":"169","volume-title":"Yeast colonisation & fungaemia in preterm neonates in a tertiary care centre","author":"Singh","year":"1999","journal-title":"Indian J Med Res","ISSN":"https:\/\/id.crossref.org\/issn\/0971-5916","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-24","first-page":"42","volume-title":"Changing trends of Candida species in neonatal septicaemia in a tertiary North Indian hospital","author":"Rani","year":"2002","journal-title":"Indian J Med Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0255-0857","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-25","first-page":"53","volume-title":"Emergence of non albicans Candida in neonatal septicemia and antifungal susceptibility: Experience from a tertiary care center","author":"Goel","year":"2009","journal-title":"J Lab Physicians","ISSN":"https:\/\/id.crossref.org\/issn\/0974-2727","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-26","first-page":"56","volume-title":"Neonatal systemic candidiasis in a tertiary care centre","author":"Narain","year":"2003","journal-title":"Indian J Med Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0255-0857","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-27","first-page":"171","volume-title":"Epidemiology of Candida bloodstream infections in a tertiary care institute in India","author":"Kothari","year":"2009","journal-title":"Indian J Med Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0255-0857","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-28","first-page":"112","volume-title":"Biofilm as a virulence marker in Candida species in nosocomial blood stream infection and its correlation with antifungal resistance","author":"Bhatt","year":"2015","journal-title":"Indian J Med Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0255-0857","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236097-29","first-page":"44","volume-title":"Species distribution and drug susceptibility of Candida in clinical isolates from a tertiary care centre at Indore","author":"Pahwa","year":"2014","journal-title":"Indian J Med Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0255-0857","issn-type":"print"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/JLP.JLP_1_18.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:15:26Z","timestamp":1703405726000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/spectrum-of-candidal-species-isolated-from-neonates-admitted-in-an-intensive-care-unit-of-teaching-hospital-of-kashmir-north-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":29,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,2,19]]},"published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.4103\/jlp.jlp_1_18","relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}