{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:32:52Z","timestamp":1776375172934,"version":"3.51.2"},"reference-count":30,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":598,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          BACKGROUND: Preeclampsia (PE) is a systemic pregnancy-related disorder characterized by hypertension, proteinuria, and edema. Free radicals seem to play an important role in the induction of endothelial dysfunction in PE.<\/jats:p><jats:p>\n          AIM: The aim of the present study was to investigate serum levels of nitric oxide (NO), peroxynitrite (ONOO\u2212), paraoxonase (PON-1), malondialdehyde (MDA), and lipid profile in preeclamptic patients compared to the women with normal pregnancy.<\/jats:p><jats:p>\n          MATERIALS AND METHODS: A total of 68 pregnant women were recruited. They were divided into two groups -\u00a0Group A, 40 women were a newly diagnosed with PE and Group B, 28 women with normal pregnancy. Anthropometric measurements including body mass index and blood pressure in accordance with biochemical measurements including NO, ONOO\u2212, PON-1, MDA, and lipid profile were done for preeclamptic pregnant women compared to the controls.<\/jats:p><jats:p>\n          RESULTS: Pregnant women with pre-eclampsia illustrated insignificant differences in the age (31.22\u00b12.87) compared to the age of control P &gt; 0.05. There were significant changes in the body mass index (BMI) , type of delivery and smoking status of pregnant women with pre-eclampsia compared to the control P &lt; 0.05. Both systolic and diastolic blood pressures were high in pregnant women with pre-eclampsia compared to the control P &lt; 0.01. PON-1 and NO serum levels were significantly decreased (P &lt; 0.01) while ONOO\u2212 and MDA serum levels were significantly increased in PE compared to the women with normal pregnancy.<\/jats:p><jats:p>\n          Conclusions: This study concluded that PE is associated with the augmentation of oxidative stress and reduction of endogenous antioxidant capacity regarding PON-1.<\/jats:p>","DOI":"10.4103\/jlp.jlp_26_18","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T05:03:48Z","timestamp":1530853428000},"page":"276-282","source":"Crossref","is-referenced-by-count":41,"title":["Concept and connotation of oxidative stress in preeclampsia"],"prefix":"10.25259","volume":"10","author":[{"given":"Hayder M.","family":"Al-Kuraishy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Medicine, College of Medicine Al Mustansiriya University, Baghdad, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali I.","family":"Al-Gareeb","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Medicine, College of Medicine Al Mustansiriya University, Baghdad, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thabat J.","family":"Al-Maiahy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Medicine, College of Medicine Al Mustansiriya University, Baghdad, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"key-10.4103\/0974-2727.236110-1","first-page":"516","volume-title":"Oxidative stress in preeclampsia and the role of free fetal hemoglobin","author":"Hansson","year":"2014","journal-title":"Front Physiol"},{"key":"key-10.4103\/0974-2727.236110-2","first-page":"144","volume-title":"Aspirin non-responsiveness in pregnant women at 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Pre-eclampsia and eclampsia: An update on the pharmacological treatment applied in Portugal. J Cardiovasc Dev Dis 2018;5. pii: E3.","DOI":"10.3390\/jcdd5010003"},{"key":"key-10.4103\/0974-2727.236110-16","doi-asserted-by":"crossref","unstructured":"Al-Kuraishy HM, Al-Gareeb AI, Al-Buhadilly AK. Rosuvastatin improves vaspin serum levels in obese patients with acute coronary syndrome. Diseases 2018;6. pii: E9.","DOI":"10.3390\/diseases6010009"},{"key":"key-10.4103\/0974-2727.236110-17","first-page":"e0139164","volume-title":"Pre-conception dyslipidemia is associated with development of preeclampsia and gestational diabetes mellitus","author":"Baumfeld","year":"2015","journal-title":"PLoS One"},{"key":"key-10.4103\/0974-2727.236110-18","unstructured":"Chung WH, To WW. Outcome of pregnancy with new onset proteinuria and progression to pre-eclampsia: A retrospective analysis. 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