{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:39:21Z","timestamp":1759412361884},"reference-count":14,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":598,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          INTRODUCTION: Hashimoto\u2019s thyroiditis (HT) is the most common cause of goitrous hypothyroidism in iodine sufficient areas. The diagnosis of HT is important because it progresses to hypothyroidism, and also, it is associated with thyroid lymphoma and papillary thyroid carcinoma. Apart from thyroid antibodies, assessment of thyroid function test (TFT) levels, ultrasonography (USG), and cytological analysis can help in early diagnosis and management of HT.<\/jats:p><jats:p>\n          AIMS AND OBJECTIVES OF THIS STUDY: To know the age incidence and clinical presentation of HT, its association with thyroid hormone levels and with thyroid antibodies and its correlation with the cytologic grade of HT.<\/jats:p><jats:p>\n          MATERIALS AND METHODS: Consecutive convenient method of sampling was adopted at the cytology clinic. Fine-needle aspiration cytology of patients presenting with thyroid enlargement was done using standard technique and aseptic precautions.<\/jats:p><jats:p>\n          RESULTS: Out of 875 cases of thyroid cytology, 134 cases were diagnosed as HT over a 4-year period. A strong female preponderance was observed. A significant proportion of them (103\/134) presented in the first four decades of life. Majority of cases (60.63%) were hypothyroid, while 15.74% were hyperthyroid and 23.62% were euthyroid. Apart from thyroid enlargement, although a majority of patients presented with symptoms related to the thyroid, a significant number of patients (38.80%) were asymptomatic.<\/jats:p><jats:p>\n          Conclusions: A combined approach of cytological grading of HT along with USG, TFT levels, and thyroid antibodies can detect hypothyroid and subclinical hypothyroid or euthyroid state of HT and provide an appropriate guide to therapy.<\/jats:p>","DOI":"10.4103\/jlp.jlp_72_17","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T05:03:48Z","timestamp":1530853428000},"page":"294-298","source":"Crossref","is-referenced-by-count":11,"title":["Importance of combined approach of investigations for detection of asymptomatic Hashimoto Thyroiditis in early stage"],"prefix":"10.25259","volume":"10","author":[{"given":"Sonali Rajesh","family":"Saraf","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin M.","family":"Gadgil","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheetal","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka D.","family":"Kalgutkar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"key-10.4103\/0974-2727.236116-1","unstructured":"Maitra A. The endocrine system. In: Kumar V, Abbas AK, Aster JC, editors. Robbins and Cotran Pathologic Basis of Disease. 9th ed., Vol. II. Philadelphia: Elsevier Saunders; 2014. p. 1082-105."},{"key":"key-10.4103\/0974-2727.236116-2","first-page":"10","volume-title":"Lymphocytic thyroiditis \u2013 Is cytological grading significant.A correlation of grades with clinical, biochemical, ultrasonographic and radionuclide parameters?","author":"Bhatia","year":"2007","journal-title":"Cytojournal","ISSN":"http:\/\/id.crossref.org\/issn\/1742-6413","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236116-3","first-page":"11","volume-title":"Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state","author":"Staii","year":"2010","journal-title":"Thyroid Res"},{"key":"key-10.4103\/0974-2727.236116-4","first-page":"9","volume-title":"Cytomorphologic spectrum of hashimoto's thyroiditis and its clinical correlation: A retrospective study of 52 patients","author":"Chandanwale","year":"2014","journal-title":"Cytojournal","ISSN":"http:\/\/id.crossref.org\/issn\/1742-6413","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236116-5","first-page":"10551","volume-title":"Cytomorphological features of hashimoto thyroiditis-with sonological and serological findings-analysis of 80 cases","author":"Sreechithra","year":"2014","journal-title":"J Evol Med Dent Sci"},{"key":"key-10.4103\/0974-2727.236116-6","first-page":"430510","volume-title":"Correlation of fine needle aspiration cytology findings with thyroid function test in cases of lymphocytic thyroiditis","author":"Sood","year":"2014","journal-title":"J Thyroid Res"},{"key":"key-10.4103\/0974-2727.236116-7","first-page":"576","volume-title":"Hashimoto's thyroiditis: From genes to the disease","author":"Zaletel","year":"2011","journal-title":"Curr Genomics"},{"key":"key-10.4103\/0974-2727.236116-8","first-page":"2500","volume-title":"Miscarriage in women with positive anti-TPO antibodies: Is thyroxine the answer?","author":"Glinoer","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/0974-2727.236116-9","first-page":"1771","volume-title":"Hashimoto's thyroiditis: A correlation of cytolomorphology with clinical, biochemical & radiological findings","author":"Kudva","year":"2015","journal-title":"Int J Sci Res"},{"key":"key-10.4103\/0974-2727.236116-10","first-page":"1","volume-title":"Cytomorphological aspects of hashimoto's thyroiditis: Our experience at a tertiary center","author":"Rathi","year":"2014","journal-title":"Clin Med Insights Pathol"},{"key":"key-10.4103\/0974-2727.236116-11","first-page":"729","volume-title":"Clinical, biochemical & cytomorphologic study on hashimoto's thyroiditis","author":"Thomas","year":"2014","journal-title":"Indian J Med Res","ISSN":"http:\/\/id.crossref.org\/issn\/0971-5916","issn-type":"print"},{"key":"key-10.4103\/0974-2727.236116-12","first-page":"S78","volume-title":"Thyroid disorders in India: An epidemiological perspective","author":"Unnikrishnan","year":"2011","journal-title":"Indian J Endocrinol Metab"},{"key":"key-10.4103\/0974-2727.236116-13","first-page":"305","volume-title":"Clinical aspects of recurrent postpartum thyroiditis","author":"Lazarus","year":"1997","journal-title":"Br J Gen Pract"},{"key":"key-10.4103\/0974-2727.236116-14","first-page":"1","volume-title":"Prevalence of antithyroid antibodies in histologically proven autoimmune thyroid diseases and correlation with thyroid dysfunction in South India","author":"Shinto","year":"2010","journal-title":"Thyroid Science"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/JLP.JLP_72_17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:15:30Z","timestamp":1703405730000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/importance-of-combined-approach-of-investigations-for-detection-of-asymptomatic-hashimoto-thyroiditis-in-early-stage\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":14,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,2,19]]},"published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.4103\/jlp.jlp_72_17","relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}