{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T08:07:04Z","timestamp":1725091624282},"reference-count":18,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":871,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune hemolytic anemia is characterized by clinical and laboratory features of hemolytic anemia with direct antiglobulin test (DAT) positivity. It could be autoimmune hemolytic anemia (AIHA), alloimmune, or drug-induced hemolysis based on the antigenic stimulus. Furthermore, based on thermal amplitude of autoantibody, AIHA is classified as warm (65%), cold (30%), and mixed (5%) type. Mixed AIHA is extremely rare in children and must be differentiated from warm AIHA with clinically insignificant cold agglutinins and cold hemagglutinin disease as their treatment is different. It may present as blood group discrepancy or cross-match incompatibility leading to delay in arranging suitable blood unit for transfusion. Therefore, a thorough immunohematology workup including monospecific DAT, indirect antiglobulin test at 4\u00b0C and 37\u00b0C, determination of thermal amplitude and titer is essential. We hereby present two pediatric cases of mixed AIHA presenting as ABO forward and reverse blood group discrepancy and cross-match incompatibility.<\/jats:p>","DOI":"10.4103\/jlp.jlp_95_17","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T05:34:11Z","timestamp":1505108051000},"page":"332-336","source":"Crossref","is-referenced-by-count":6,"title":["Rare presentation of mixed autoimmune hemolytic anemia in children: Report of 2 cases"],"prefix":"10.25259","volume":"9","author":[{"given":"Preeti","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetika","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deeksha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"key-10.4103\/0974-2727.214271-1","unstructured":"De Gruchy GC. The haemolytic anaemias. In: Firkin FC, Chesterman CN, Penington DG, Rush BM, editors. De Gruchy's Clinical Haematology in Medical Practice. 5th ed. Edinburgh: Blackwell Science Ltd.; 1989. p. 172-215."},{"key":"key-10.4103\/0974-2727.214271-2","first-page":"258","volume-title":"Autoimmune hemolytic anemia","author":"Gehrs","year":"2002","journal-title":"Am J Hematol"},{"key":"key-10.4103\/0974-2727.214271-3","first-page":"395","volume-title":"The diagnosis and management of primary autoimmune haemolytic anaemia","author":"Hill","year":"2017","journal-title":"Br J Haematol"},{"key":"key-10.4103\/0974-2727.214271-4","unstructured":"Segel GB. Hemolytic anemias resulting from extracellular factors. In: Behrman RE, Kliegman RM, Jenson HB, editors. Nelson Textbook of Pediatrics. 18th ed. 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