{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:17:24Z","timestamp":1791598644482,"version":"4.3.4"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Being one of the most common abdominal surgical procedures, numerous techniques have been adapted to decrease post-operative pain post cholecystectomy. However, the efficacy of intravenous (IV) lidocaine in managing post operative pain after LC is still controversial, according to many recent studies. This study aims to detect the effectiveness of IV lidocaine compared to other medications in managing post-operative pain. PubMed, Scopes, Web of Science and Cochrane Library were searched for eligible studies from inception to June 2023, and a systematic review and meta-analysis was done. According to eligibility criteria, 14 studies (898 patients) were included in our study. The pooled results of the included studies showed that the pain score after 6, 12 and 24 h after the surgery was significantly lower in those who received IV lidocaine as a painkiller (Visual Analogue Scale [VAS] 6H, mean difference [MD] = \u22121.20, 95% confidence interval [CI] = \u22122.20, \u22120.20,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.02;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 98%, VAS 12H, MD = \u22120.90, 95% CI = \u22121.52, \u22120.29,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.004;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 96% and VAS 24H, MD = \u22120.86, 95% CI = \u22121.48, \u22120.24,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.007;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 92%). In addition, IV lidocaine is associated with a significant decrease in the opioid requirement after the surgery (opioid requirements, MD = \u221229.53, 95% CI = \u221255.41, \u22123.66,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.03;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 98%). However, there was no statistically significant difference in the incidence of nausea and vomiting after the surgery between the two groups (nausea and vomiting, relative risk = 0.91, 95% CI = 0.57, 1.45,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.69;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 50%). Lidocaine infusion in LC is associated with a significant decrease in post operative pain and in opioid requirements after the surgery.\n                  <\/jats:p>","DOI":"10.4103\/jmas.jmas_265_23","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T07:03:09Z","timestamp":1705647789000},"page":"239-246","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["The use of lidocaine infusion in laparoscopic cholecystectomy: An updated systematic review and meta-analysis"],"prefix":"10.4103","volume":"20","author":[{"given":"Bakhtawar","family":"Awan","sequence":"first","affiliation":[{"name":"Department of General and Emergency Surgery, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elsaigh","sequence":"additional","affiliation":[{"name":"Department of General and Emergency Surgery, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beshoy Effat","family":"Elkomos","sequence":"additional","affiliation":[{"name":"Department of General and Emergency Surgery, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azka","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of General and Emergency Surgery, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Asqalan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Norfolk and Norwich University Hospital, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa Owhida Mousa","family":"Baqar","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Derriford Hospital, University Hospital Plymouth, Plymouth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha Ahmed","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Department of Acute and Emergency Medicine, Frimley Park Hospital, Frimley, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omnia S.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Division of General and GI Surgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna Malgorzata","family":"Szul","sequence":"additional","affiliation":[{"name":"Department of General and Emergency Surgery, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, 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