{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:55:59Z","timestamp":1794048959159,"version":"4.8.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Minimally invasive sphincter preserving procedures like ligation of intersphincteric fistula tract (LIFT) and video-assisted anal fistula treatment (VAAFT) are being increasingly used in the treatment of fistula-in-ano. The addition of adjuncts like fibrin glue has improved the results for VAAFT. Our unit has used platelet-rich fibrin (PRF) as an innovative adjunct for VAAFT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To compare the effectiveness of two different adjuncts, fibrin glue and autologous PRF, used to fill the treated fistula tracts following VAAFT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>Retrospective observational study on a cohort of patients undergoing VAAFT at a tertiary centre between 2015 and 2020 comparing two adjuncts used with VAAFT procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>Data of patients who underwent VAAFT for fistula-in-ano were obtained from the hospital database. Group A included patients treated with fibrin as adjunct and PRF as adjunct in Group B. Patients were followed up at 1, 3 and 6 months post-operatively and by a telephonic interview in 2020 to ascertain recent status. All data were entered into an excel sheet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>\n                      Data were analysed using SPSS V20 to test the statistical significance of the difference in the mean healing time between two groups, Mann\u2013Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      -test was used and for age, Student's\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test was used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 41 patients in Group A and 24 in Group B. There was a significant reduction in recurrence rate in Group B (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.032) and in those patients who had a single internal opening (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.045), single external opening (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) and complex tracts (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.033). PRF was cheaper than Fibrin glue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PRF is more effective and economical with lower recurrence rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmas.jmas_297_21","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T05:59:08Z","timestamp":1642744748000},"page":"443-449","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Fibrin glue versus autologous platelet-rich fibrin - comparison of effectiveness on the cohort of patients with fistula-in-ano undergoing video-assisted anal fistula treatment"],"prefix":"10.4103","volume":"18","author":[{"given":"Riju","family":"Ramachandran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishnavi","family":"Gunasekharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop Vasudevan","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyambu","family":"Raja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjaly S","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20240828","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10151-011-0769-2","article-title":"Video-Assisted Anal Fistula Treatment (VAAFT): A novel sphincter-saving procedure for treating complex anal fistulas","volume":"15","author":"Meinero","year":"2011","journal-title":"Tech Coloproctol"},{"key":"R3-19-20240828","doi-asserted-by":"crossref","first-page":"203943","DOI":"10.1155\/2014\/203943","article-title":"Fibrin sealant: The only approved hemostat, sealant, and adhesive \u2013 A laboratory and clinical perspective","volume":"2014","author":"Spotnitz","year":"2014","journal-title":"ISRN Surg"},{"key":"R4-19-20240828","doi-asserted-by":"crossref","first-page":"e2014","DOI":"10.4293\/JSLS.2014.00127","article-title":"Video-assisted anal fistula treatment","volume":"18","author":"Kochhar","year":"2014","journal-title":"JSLS"},{"key":"R5-19-20240828","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bjs.1800630102","article-title":"A classification of fistula-in-ano","volume":"63","author":"Parks","year":"1976","journal-title":"Br J Surg"},{"key":"R6-19-20240828","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.3748\/wjg.v17.i28.3292","article-title":"Why do 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fistula: Hope or hype?","volume":"27","author":"Scoglio","year":"2014","journal-title":"Clin Colon Rectal Surg"},{"key":"R11-19-20240828","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/fjs.fjs_68_20","article-title":"Video-assisted anal fistula treatment: A single-center experience to opt the right tract","volume":"53","author":"Raja","year":"2020","journal-title":"Formos J Surg"},{"key":"R13-19-20240828","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4103\/amjm.amjm_58_20","article-title":"Autologous platelet-rich fibrin to treat difficult nonhealing diabetic foot wounds with exposed bone \u2013 A case report of this safe, effective, and economical method","volume":"16","author":"Menon","year":"2020","journal-title":"Amrita J Med"},{"key":"R14-19-20240828","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.tripleo.2005.07.010","article-title":"Platelet-Rich Fibrin (PRF): A second-generation platelet concentrate.Part III: Leucocyte activation: A new feature for platelet concentrates?","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R15-19-20240828","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1016\/j.tripleo.2005.07.011","article-title":"Platelet-Rich Fibrin (PRF): A second-generation platelet concentrate.Part IV: Clinical effects on tissue healing","volume":"101","author":"Choukroun","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R16-19-20240828","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1160\/TH03-07-0440","article-title":"Autologous platelets as a source of proteins for healing and tissue regeneration","volume":"91","author":"Anitua","year":"2004","journal-title":"Thromb Haemost"},{"key":"R17-19-20240828","first-page":"3532","article-title":"Platelets and wound healing","volume":"13","author":"Nurden","year":"2008","journal-title":"Front Biosci"},{"key":"R18-19-20240828","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/amjm.amjm_70_20","article-title":"Autologous platelet-rich fibrin in the management of recurrent complex fistula in ano: A novel safer and cost-effective approach","volume":"17","author":"Ramachandran","year":"2021","journal-title":"Amrita J Med"},{"key":"R19-19-20240828","first-page":"e4200","article-title":"Factors increasing the risk of recurrence in fistula-in-ano","volume":"11","author":"Bakhtawar","year":"2019","journal-title":"Cureus"}],"container-title":["Journal of Minimal Access 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