{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:59Z","timestamp":1787840339583,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The aim of this study was to analyse the effect of perioperative dexmedetomidine (DEX) application on stress response, post-operative pain and prognosis in patients undergoing gynaecologic laparoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>\n                      One hundred and sixty-eight patients admitted for gynaecologic laparoscopic surgery from May 2020 to November 2022 were included in the study. The patients were randomly divided into pre-operative DEX group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 56), intraoperative DEX group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 56) and post-operative DEX group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 56) according to the application of DEX in the perioperative period. The visual analogue scale (VAS), time awake, extubation time, pneumoperitoneum time, post-anaesthesia care unit (PACU) stay time and Richmond agitation-sedation scale score (RASS) were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients in both the pre-operative and intraoperative DEX groups had substantially shorter wakeup and extubation times than those in the post-operative DEX group. Patients in the pre-operative DEX group had considerably shorter wakeup and extubation times than those in the intraoperative DEX group, and their pneumoperitoneum time was significantly shorter than that of the post-operative DEX group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The RASS scores of the pre-operative DEX group and intraoperative DEX group were significantly lower than those of the post-operative DEX group at 1 h, 6 h and 12 h after surgery. Meanwhile, at all time periods, the RASS scores of patients in the pre-operative DEX group were considerably lower than those in the intraoperative DEX group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). The VAS scores of patients in the pre-operative DEX group and intraoperative DEX group were evidently lower than those in the post-operative DEX group at 0.5 h, 2 h and 12 h postoperatively, and the VAS scores of patients in the pre-operative DEX group were markedly lower than those in the intraoperative DEX group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The incidence of nausea and vomiting was significantly lower in the pre-operative DEX group than in the intraoperative DEX group and the post-operative DEX group at 0\u20132 h, &gt;2\u201312 h and &gt;12\u201324 h postoperatively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The incidence of nausea and vomiting in the intraoperative DEX group was significantly lower than that in the post-operative DEX group from 0 to 2 h after surgery (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The incidence of adverse reactions was not significantly different amongst the three groups of patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Pre-operative and intraoperative application of DEX can help reduce post-operative pain and stress responses, help patients recover quickly after surgery and improve patient prognosis, especially the pre-operative application of DEX.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmas.jmas_47_23","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T13:01:15Z","timestamp":1692018075000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Effect of perioperative application of dexmedetomidine on post-operative stress reaction, pain and prognostic adverse effects in patients undergoing gynaecological laparoscopy"],"prefix":"10.4103","volume":"20","author":[{"given":"Xing","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Public Health Response, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"R1-20250109","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/jamasurg.2020.1953","article-title":"Effect of surgical skin antisepsis on surgical site infections in patients undergoing gynecological laparoscopic surgery:A double-blind randomized clinical trial","volume":"155","author":"Dior","year":"2020","journal-title":"JAMA Surg"},{"key":"R2-20250109","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/JCMA.0000000000000190","article-title":"Pain after laparoscopic surgery:Focus on shoulder-tip pain after gynecological laparoscopic surgery","volume":"82","author":"Sao","year":"2019","journal-title":"J Chin Med Assoc"},{"key":"R3-20250109","first-page":"641","article-title":"Effects of multimodal analgesia of flurbiprofen axetil, nalbuphine and patient controlled intravenous analgesia on inflammatory factor levels and stress response in patients after laparoscopic radical gynecological malignancy surgery","volume":"35","author":"An","year":"2022","journal-title":"Pak J Pharm Sci"},{"key":"R4-20250109","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0140-6736(20)30631-0","article-title":"Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE):A randomised placebo-controlled trial","volume":"396","author":"Turan","year":"2020","journal-title":"Lancet"},{"key":"R5-20250109","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/ALN.0000000000003725","article-title":"Balanced opioid-free anesthesia with dexmedetomidine versus balanced anesthesia with remifentanil for major or intermediate noncardiac surgery","volume":"134","author":"Beloeil","year":"2021","journal-title":"Anesthesiology"},{"key":"R6-20250109","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/anae.14657","article-title":"Intra-operative analgesia with remifentanil versus dexmedetomidine:A systematic review and meta-analysis with trial sequential analysis","volume":"74","author":"Grape","year":"2019","journal-title":"Anaesthesia"},{"key":"R7-20250109","doi-asserted-by":"crossref","first-page":"e2128886","DOI":"10.1001\/jamanetworkopen.2021.28886","article-title":"Effect of Intraoperative dexmedetomidine on recovery of gastrointestinal function after abdominal surgery in older adults:A randomized clinical trial","volume":"4","author":"Lu","year":"2021","journal-title":"JAMA Netw Open"},{"key":"R8-20250109","doi-asserted-by":"crossref","first-page":"e0169525","DOI":"10.1371\/journal.pone.0169525","article-title":"Dexmedetomidine versus midazolam in procedural sedation. 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