{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:35:54Z","timestamp":1787758554327,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP), an immune mediated disorder, has been recognized since 1869 and is presented as any one of the six variants. Reticular and erosive are the most frequently encountered. Its proliferative capacity can give some information regarding its progression. We adopted the argyrophilic nucleolar organizer regions (AgNORs) method because of its simplicity to use and dependable results. We evaluated AgNORs in basal, suprabasal, and squamous cell layers. We also compared these three layers within two variants, reticular, and erosive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Thirty clinically diagnosed patients of OLP were included in the study. Reticular and erosive variants were included in our study. This was followed by hematoxylin and eosin staining and later by the AgNOR method. The mean number of AgNORs per nucleus was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirteen males and 17 females were the gender distribution. Twenty-three (76.67%) had reticular pattern and seven (23.33%) had erosive pattern. The basal cell layer had the highest mean AgNOR compared to suprabasal and squamous layers. Even among, erosive and reticular variants, the former had higher mean AgNOR counts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Our results suggest that the inflammatory infiltrate close to the epithelial cells can alter the proliferation index for the pattern of protein synthesis of these cells. Moreover, the high proliferative index in OLP can be related to a specific immunologic response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We conclude that AgNOR can be used as a proliferative marker in earlier lesions to detect the severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmau.jmau_104_20","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T04:23:35Z","timestamp":1669868615000},"page":"12-16","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["A Comparison of Proliferative Capacity of Reticular and Erosive Variants of Oral Lichen Planus by Argyrophilic Nucleolar Organizer Regions Method"],"prefix":"10.4103","volume":"11","author":[{"given":"Swati Shrikant","family":"Gotmare","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish A","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandavi","family":"Waghmare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Kavle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Rathod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Sonawne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Treville","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20240830","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1600-0714.1990.tb00866.x","article-title":"Immunopathogenesis of oral lichen planus","volume":"19","author":"Walsh","year":"1990","journal-title":"J Oral Pathol Med"},{"key":"R2-2-20240830","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4103\/0976-237X.137946","article-title":"Oral lichen planus and stress: An appraisal","volume":"5","author":"Sandhu","year":"2014","journal-title":"Contemp Clin Dent"},{"key":"R3-2-20240830","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4103\/0976-9668.136248","article-title":"Unilateral lichen planus: A rare case report","volume":"5","author":"Bajpai","year":"2014","journal-title":"J Nat Sci Biol Med"},{"key":"R4-2-20240830","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1054\/bjom.2000.0335","article-title":"Oral lichen planus: A review","volume":"38","author":"Mollaoglu","year":"2000","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R5-2-20240830","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.oraloncology.2017.03.012","article-title":"Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data","volume":"68","author":"Aghbari","year":"2017","journal-title":"Oral Oncol"},{"key":"R6-2-20240830","first-page":"261","article-title":"Oral lichen planus and malignant transformation: A retrospective follow-up study of clinical and histopathologic data","volume":"37","author":"Bornstein","year":"2006","journal-title":"Quintessence Int"},{"key":"R7-2-20240830","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1590\/S0365-05962010000500010","article-title":"Oral lichen planus (OLP): Clinical and complementary diagnosis","volume":"85","author":"Canto","year":"2010","journal-title":"An Bras Dermatol"},{"key":"R8-2-20240830","first-page":"11","article-title":"AgNORs, PCNA and histologic activity index in chronic liver disease","volume":"29","author":"Ceyhan","year":"1999","journal-title":"Tr J Med Sci"},{"key":"R9-2-20240830","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/BF00374060","article-title":"The relation of a particular chromosomal element to the development of the nucleoli in Zea mays. 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